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Treatment of Graves’ ophthalmopathy
Medicina Clínica (English Edition), 2021Graves' ophthalmopathy is an inflammatory disease with primary involvement of the extraocular muscles and the orbit. It encompasses the most common extra-thyroid manifestation in patients with Graves-Basedow disease. The underlying cause is molecular mimicry with the TSH receptor in ocular fibroblasts, leading to an immuno-mediated pathogenesis ...
Andrés, González-García +1 more
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The American Journal of the Medical Sciences, 2011
The authors reported 2 cases of Hashimoto's ophthalmopathy. These cases presented with no preceding illness; euthyroid state; acute presentation of painful or painless ophthalmoplegia, preferentially affecting the lateral rectus muscles; positive antithyroglobulin/antithyroid peroxidase antibodies and good responses to steroid treatment.
Fuyuki, Tateno +3 more
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The authors reported 2 cases of Hashimoto's ophthalmopathy. These cases presented with no preceding illness; euthyroid state; acute presentation of painful or painless ophthalmoplegia, preferentially affecting the lateral rectus muscles; positive antithyroglobulin/antithyroid peroxidase antibodies and good responses to steroid treatment.
Fuyuki, Tateno +3 more
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Current Opinion in Ophthalmology, 1994
Thyroid ophthalmopathy, idiopathic orbital inflammation, and orbital infection can occasionally demonstrate overlapping clinical features. It is essential to distinguish between these processes because appropriate treatments are distinct in each case.
E G, Faktorich, N, Tucker, J M, O'Brien
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Thyroid ophthalmopathy, idiopathic orbital inflammation, and orbital infection can occasionally demonstrate overlapping clinical features. It is essential to distinguish between these processes because appropriate treatments are distinct in each case.
E G, Faktorich, N, Tucker, J M, O'Brien
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Arkhiv patologii, 2022
IgG4-related disease is a chronic inflammatory fibrosing disease of unknown etiology, characterized by the presence of volumetric lesions that can clinically simulate malignant tumors, a pronounced IgG4-positive lymphoplasmacytic infiltrate, and an increase in the level of IgG4 in the blood serum.
S.G. Radenska-Lopovok +3 more
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IgG4-related disease is a chronic inflammatory fibrosing disease of unknown etiology, characterized by the presence of volumetric lesions that can clinically simulate malignant tumors, a pronounced IgG4-positive lymphoplasmacytic infiltrate, and an increase in the level of IgG4 in the blood serum.
S.G. Radenska-Lopovok +3 more
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IMMUNOGENETICS OF GRAVES' OPHTHALMOPATHY
Clinical Endocrinology, 1988SUMMARYWe have performed an immunogenetic analysis of 53 patients with severe Graves' ophthalmopathy, 51 patients with Graves' disease but little or no clinically apparent eye disease, and 90 controls. The distribution of restriction fragment length polymorphisms was analysed in the three groups, using probes for the HLA‐DQα and DRβ regions, the T‐cell
A P, Weetman +5 more
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Current Opinion in Ophthalmology, 2001
Graves ophthalmopathy (GO) is an autoimmune disease that typically affects the thyroid gland and the orbit. The roles of the thyroid stimulating hormone receptor and cellular and humoral immunity in the pathogenesis of GO are being investigated. Investigators are gaining insights into the epidemiology of GO as it relates to other ocular and autoimmune ...
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Graves ophthalmopathy (GO) is an autoimmune disease that typically affects the thyroid gland and the orbit. The roles of the thyroid stimulating hormone receptor and cellular and humoral immunity in the pathogenesis of GO are being investigated. Investigators are gaining insights into the epidemiology of GO as it relates to other ocular and autoimmune ...
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Ophthalmodynamometry and ischemic ophthalmopathy
Graefe's Archive for Clinical and Experimental Ophthalmology, 2008To report on the clinical application of a modified ophthalmodynamometer for the detection of ischemic ophthalmopathy.A 70-year-old patient showed unilateral loss of vision to 1/20, thin retinal arteries, tiny intraretinal hemorrhages, and iris neovascularization. We performed a modified ophthalmodynamometry using a Goldmann contact lens in the holding
Jost B, Jonas, Feras, Kaltakji
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Ciclosporine and Graves’ Ophthalmopathy
Hormone Research, 2008The pharmacological treatment of Graves’ ophthalmopathy remains unsatisfactory due to the limited efficacy and severe side effects of the available drugs. Ciclosporine, an immunosuppressive drug has recently been used with the aim of controlling the autoimmune process considered to be responsible for the disease.
J P, Gayno, G, Strauch
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Medical Clinics of North America, 1995
Graves' ophthalmopathy is an organ-specific autoimmune process strongly linked to Graves' hyperthyroidism. Although the hyperthyroidism can be successfully treated, it is often the ophthalmopathy that produces the greatest long-term disability for patients suffering from this disease.
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Graves' ophthalmopathy is an organ-specific autoimmune process strongly linked to Graves' hyperthyroidism. Although the hyperthyroidism can be successfully treated, it is often the ophthalmopathy that produces the greatest long-term disability for patients suffering from this disease.
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Prevention of Graves’ ophthalmopathy
Best Practice & Research Clinical Endocrinology & Metabolism, 2012Smoking is the most important risk factor for the occurrence/progression of Graves' ophthalmopathy (GO), as well as for its lower/slower response to immunosuppression. Accordingly, refrain from smoking should be urged, both as primary prevention (removal of risk factors in Graves' patients without GO), secondary prevention (early detection and ...
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