Results 111 to 120 of about 313,201 (307)

Youth Participatory Action Research: A Promising Strategy for Preventing Opioid Misuse [PDF]

open access: yes
This is a research brief describing youth participatory action research, evaluation findings of an opioid-related project, and related ...
Northwest Rural Opioid Technical Assistance Collaborative
core   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Risk factors for discontinuing intravenous patient-controlled analgesia after thoracic surgery

open access: yesAnnals of Thoracic Medicine
PURPOSE: This study examined the risk factors of experiencing side effects from using intravenous patient-controlled analgesia (IV PCA) following lung and esophageal surgery.
Saeyeon Kim   +3 more
doaj   +1 more source

Opioid pharmacotherapy: delivery in community pharmacy

open access: yes, 2019
[Extract] Opioid substitution has been recognised globally as an effective harm minimisation strategy for the treatment of opioid addiction. Key principles behind opioid substitution are to reduce or cease licit and illicit opioid use, to reduce the risk
Felkai, Chelsea   +3 more
core  

Negative affect, pain and sex: The role of endogenous opioids [PDF]

open access: yes, 2007
Opioid neurotransmission modulates pain and negative affect during psychological stress. To determine whether these effects differ between men and women, the opioid receptor antagonist naltrexone or placebo was administered double-blind to 21 men and 22 ...
Frew, A.K., Drummond, P.D.
core  

Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems

open access: yes, 2010
Amanzio and Benedetti (J Neurosci 1999; 19: 484-494) first addressed the conditions necessary for the activation of opioid and non-opioid placebo responses in human. Here, we investigated whether placebo analgesia is subdivided into opioid and non-opioid
Wang, JY, Guo, JY, Luo, F, Luo F
core   +1 more source

Acute toxic leucoencephalopathy following protonitazene ingestion

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Background Distribution of illicit counterfeit alprazolam containing the highly potent synthetic opioid‐receptor agonist protonitazene recently resulted in a number of severe overdoses in Ireland. We report three cases that presented to our hospital, within 6 weeks of one another, following ingestion of illicitly‐sourced alprazolam.
Ruadhan O'Laoi   +5 more
wiley   +1 more source

Comparison of intrathecal morphine versus erector spinae block for postoperative analgesia in patients with end-stage kidney disease undergoing kidney transplantation: A randomised clinical study

open access: yesIndian Journal of Anaesthesia
Background and Aims: Intrathecal morphine (ITM) or erector spinae plane (ESP) block reduces postsurgical pain in patients who underwent kidney transplantation surgeries.
Saurabh Mittal   +3 more
doaj   +1 more source

Translational development of crisugabalin for neuropathic pain

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João   +5 more
wiley   +1 more source

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