Results 111 to 120 of about 269,209 (316)
The effect of subcutaneous naloxone on experimentally induced pain
, 2008 The heat pain threshold was assessed in 32 healthy participants after a mild burn on the dorsal surface of each hand, after injection of an opioid antagonist (80 μg naloxone) or vehicle alone (0.2 mL saline) into the burnt skin of 1 hand, and after ...
Hammond, G.R. +2 more
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British Journal of Clinical Pharmacology, EarlyView.Background Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under‐reporting remains widespread. We tested a novel method to increase reporting of ADR‐related hospitalizations.
Georgia Anita Weber +7 more
wiley +1 more source
Precision medicine in paediatrics: Progress and priorities
British Journal of Clinical Pharmacology, EarlyView.Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain +3 more
wiley +1 more source
Negative affect, pain and sex: The role of endogenous opioids
, 2007 Opioid neurotransmission modulates pain and negative affect during psychological stress. To determine whether these effects differ between men and women, the opioid receptor antagonist naltrexone or placebo was administered double-blind to 21 men and 22 ...
Frew, A.K., Drummond, P.D.
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Reducing opioid-related deaths in the UK [PDF]
, 2016 This independent report by the Advisory Council on the Misuse of Drugs investigates the increase of drug-related deaths in the UK. It looks at: - patterns and trends in opioid-related deaths - causes and drivers of trends in opioid-related deaths
Dale-Perera, Annette +2 more
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Exploring new avenues: Psychedelic‐assisted therapy for young people
British Journal of Clinical Pharmacology, EarlyView.Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou +3 more
wiley +1 more source
Dopaminergic and Opioid Systems Interact to Produce Peripheral Antinociception in Mice
Journal of Integrative NeuroscienceBackground: The overall pain experience results from the balance between the nociceptive pathway and the body’s endogenous modulation of nociception. The interaction of these systems reduces nociception.
Bárbara F. G. Queiroz +5 more
doaj +1 more source
The Role of Opioids on Motor Activity in Physio-pathological Conditions
, 2009 To date, four principal classes of opioid peptide receptors, μ (MOP), κ (KOP), δ (DOP) and ORL- 1 (NOP) have been identified and cloned. The experimental and clinical importance of this receptor family has been amply demonstrated in many diseases ...
Mabrouk, Omar Sharif
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