Results 131 to 140 of about 269,209 (316)
JTCVS OpenObjective: This study investigated the efficacy of a multimodal analgesia (MMA) with an opioid-sparing strategy, incorporating a parasternal plane block (PPB) within a systematic standardized Enhanced Recovery After Surgery (ERAS) program for patients ...
Marc Darras, MD +9 more
doaj +1 more source
Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview
Chemistry – A European Journal, EarlyView.The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati +4 more
wiley +1 more source
Opioid pharmacotherapy: delivery in community pharmacy
, 2019 [Extract] Opioid substitution has been recognised globally as an effective harm minimisation strategy for the treatment of opioid addiction. Key principles behind opioid substitution are to reduce or cease licit and illicit opioid use, to reduce the risk
Felkai, Chelsea +3 more
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, 2015 Joseph A Boscarino,1 Stuart N Hoffman,1 John J Han2 1Center for Health Research, 2Department of Pain Medicine, Geisinger Clinic, Danville, PA, USAAims: Previously, we estimated the prevalence and risk factors for prescription opioid-use disorder among ...
John Han +5 more
core +1 more source
Annals of the Child Neurology Society, EarlyView.ABSTRACT Objective Pediatric neuropalliative medicine (PNPM) is a recently developed area of subspecialty neurology practice focused on supporting the complex emotional, psychological, and physical aspects of caring for a child with serious neurological disease.
Lauren Treat +2 more
wiley +1 more source
A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation
Clinical Pharmacology &Therapeutics, EarlyView.The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix +4 more
wiley +1 more source
Magnesium\'s efficacy alone and in combinations in reducing perioperative pain and opioid consumption: A comprehensive narrative review [PDF]
Journal of Clinical and Basic ResearchBackground: Postoperative pain poses a high risk of psychological and physical trauma to surgical patients. Magnesium sulfate (MgSO₄) is inexpensive, safe, and has been used in many anesthesia procedures to evaluate its role in reducing perioperative ...
Tahseen Assad Hasan +6 more
doaj
Understanding the opioid overdose epidemic [PDF]
The number of drug overdose deaths increased by nearly 30% from 2019 to 2020 and has quintupled since 1999. Nearly 75% of the 91,799 drug overdose deaths in 2020 involved an opioid.
core
Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans
Clinical Pharmacology &Therapeutics, EarlyView.Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley +1 more source