Results 191 to 200 of about 640,835 (387)

Spinal antinociceptive actions and naloxone reversibility of intravenous μ‐ and κ‐opioids in spinalized rats: potency mismatch with values reported for spinal administration [PDF]

, 1989
Chris G. Parsons, David C. West, P.M. Headley   +2 more
openalex   +1 more source

High‐throughput liquid chromatography‐vacuum differential mobility spectrometry‐mass spectrometry for the analysis of isomeric drugs of abuse in human urine

Drug Testing and Analysis, EarlyView.
This report describes the potential of vacuum differential mobility spectrometry (DMS) as an additional separation dimension to reduce liquid chromatography (LC‐MS) analysis time while maintaining good quantitative performance. A 1‐min trap/elute LC‐vDMS‐SIM/MS method for quantification of 11 drugs of abuse was developed and applied to the analysis of ...
Maria Fernanda Cifuentes Girard, Patrick Knight, Gérard Hopfgartner   +2 more
wiley   +1 more source

Isolation and characterization of the opioid peptides from rat pituitary: beta-lipotropin.

, 1977
Menachem Rubinstein, S Stein, L D Gerber, Sidney Udenfriend   +3 more
openalex   +1 more source

Multianalyte Approach—Including Automated Preparation of Calibrators—for Validated Quantification of 82 Drugs in Whole Blood by Liquid Chromatography–Tandem Mass Spectrometry

Drug Testing and Analysis, EarlyView.
In forensic bioanalysis, often multianalyte approaches are used given their increased effectiveness but can be difficult to develop and maintain in the laboratory, for example, in terms of calibrator solution preparation. A fast, simple, and robust liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the quantification of 82 classic ...
Andrea E. Steuer, Maja Keller, Thomas Kraemer, Sandra N. Poetzsch   +3 more
wiley   +1 more source

Interaction of opioid molecules with PS, PC and PS/PC monolayers [PDF]

, 1988
M. A. Alsina, C. Mestres, G. Valencia, J. M. García Antón, F. Reig   +4 more
openalex   +1 more source

Waxy‐ or Putty‐Like Materials as a Novel Drug Preparation for Synthetic Cannabinoid Receptor Agonists: Detection in Prisons and In Vitro Cannabinoid Receptor Activity

Drug Testing and Analysis, EarlyView.
Waxy‐ or putty‐like materials has emerged as a novel drug preparation for synthetic cannabinoids and other drugs in UK prisons. An in vitro CB1 bioassay was used to evaluate the CB1 activating potential of MDMB‐INACA and extracts from eight seized samples. MDMB‐INACA had moderate efficacy but low potency at CB1.
Axelle Timmerman, Marie H. Deventer, Rachael Andrews, Robert Reid, Victoria Marland, Darren Edwards, Christopher R. Pudney, Niamh Nic Daéid, Christophe P. Stove, Caitlyn Norman   +9 more
wiley   +1 more source

Opioid-mediated suppression of interferon-gamma production by cultured peripheral blood mononuclear cells. [PDF]

, 1987
Phillip K. Peterson, Burt M. Sharp, Genya Gekker, Charles Brummitt, William F. Keane   +4 more
openalex   +1 more source

Retrospective Evaluation of Novel Synthetic Opioids and Xylazine Chronic Intake by Post‐Mortem Hair Testing

Drug Testing and Analysis, EarlyView.
The study presents a validated UPLC‐MS/MS method applied for the detection of fentanyl, NPFs, xylazine, nitazenes in hair samples from 250 post‐mortem cases collected at the Jefferson County Coroner/Medical Examiner's Office (Birmingham, AL, USA). In 52% of the analyzed hair samples, fentanyl, its main metabolites, and related analogs were detected ...
Marco Ballotari, Nicola Pigaiani, Anna Bacci, Karen S. Scott, Gregory G. Davis, Rossella Gottardo, Federica Bortolotti   +6 more
wiley   +1 more source

A dynorphin-like opioid in the central nervous system of an amphibian. [PDF]

, 1982
R I Cone, Alan Goldstein
openalex   +1 more source

Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA

Drug Testing and Analysis, EarlyView.
Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer, Maria Carmela Emanuele, Brianna N. Stang, Katleen Van Uytfanghe, Jessica Masson, Xavier Bouvot, Catherine Lamoureux, Alessandro Proposito, Fabiano Reniero, Margaret V. Holland, Alex J. Krotulski, Luisa Mannina, Christophe P. Stove, Claude Guillou   +13 more
wiley   +1 more source