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2024 Advances in Learning Health System Sciences (AiLHSS) Conference: Abstracts
Learning Health Systems, EarlyView.
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Surgical Neurology, 2007
Opioids are the most effective and widely used drugs in the treatment of severe pain. They act through G protein-coupled receptors. Four families of endogenous ligands (opioid peptides) are known. The standard exogenous opioid analgesic is morphine. Opioid agonists can activate central and peripheral opioid receptors. Three classes of opioid receptors (
C, Zöllner, C, Stein
openaire +4 more sources
Opioids are the most effective and widely used drugs in the treatment of severe pain. They act through G protein-coupled receptors. Four families of endogenous ligands (opioid peptides) are known. The standard exogenous opioid analgesic is morphine. Opioid agonists can activate central and peripheral opioid receptors. Three classes of opioid receptors (
C, Zöllner, C, Stein
openaire +4 more sources
Opioid mechanisms and opioid drugs
Anaesthesia & Intensive Care Medicine, 2008Abstract The opioid system comprises four receptor subtypes: μ (MOP), κ (KOP), δ (DOP) (i.e. the so-called ‘classical' opioid receptors) and the more recently identified nociceptin/orphanin FQ peptide (N/OFQ) receptor (NOP). Selective endogenous peptides, typically cleaved from larger precursor proteins, have been identified for all subtypes.
McDonald, J, Lambert, DG
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Opioid and non-opioid analgesics
Best Practice & Research Clinical Anaesthesiology, 2003Opioids are the most potent analgesics. Toxicity results either from effects mediated by variation in affinity and intrinsic efficacy at specific opioid receptors or, rarely, from a direct toxic effect of the drugs. For some adverse effects, opioids exhibit a 'dual pharmacology' whereby these effects are usually observed only in pain-free individuals ...
Gail Gillespie +2 more
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Prevention and Treatment of Opioid Misuse and Addiction: A Review
JAMA psychiatry, 2019Importance More than 42 000 Americans died of opioid overdoses in 2016, and the fatalities continue to increase. This review analyzes the factors that triggered the opioid crisis and its further evolution, along with the interventions to manage and ...
N. Volkow +3 more
semanticscholar +1 more source
Opioid receptor polymorphismsand opioid abuse [PDF]
Pharmacogenomics, 2002 The sequencing of the human genome is only the first step. The next step is to determine the function of these genes and in particular, how alterations in specific genes lead to major human disorders. Many laboratories are now focusing on identifying and characterizing single nucleotide polymorphisms (SNPs), to determine which correlate in frequency ...
Andrew P. Smith, Nancy M. Lee
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Annals of Internal Medicine, 2015
Chronic pain, often defined as pain lasting longer than 3 months or past the normal time for tissue healing, is common and is a major cause of decreased quality of life and disability (1, 2).
R. Chou +8 more
semanticscholar +1 more source
Chronic pain, often defined as pain lasting longer than 3 months or past the normal time for tissue healing, is common and is a major cause of decreased quality of life and disability (1, 2).
R. Chou +8 more
semanticscholar +1 more source
Neuroimaging Clinics of North America, 2006
Many breakthrough scientific discoveries have been made using opioid imaging. Developments include the application of ever higher resolution whole-brain positron emission tomography (PET) scanners, the availability of several radioligands, the combination of PET with advanced structural imaging, advances in modeling macroparameters of PET ligand ...
Hammers, Alexander +1 more
openaire +4 more sources
Many breakthrough scientific discoveries have been made using opioid imaging. Developments include the application of ever higher resolution whole-brain positron emission tomography (PET) scanners, the availability of several radioligands, the combination of PET with advanced structural imaging, advances in modeling macroparameters of PET ligand ...
Hammers, Alexander +1 more
openaire +4 more sources
New England Journal of Medicine, 2011
To the Editor: We applaud the article by Okie (Nov. 18 issue)1 on the increasing number of overdose deaths, since we have seen far too many patients die prematurely of opioid overdoses. One topic was missing from this article: the usefulness of providing access to naloxone to be administered by laypersons to prevent death from an opioid overdose ...
Michelle McKenzie +2 more
openaire +7 more sources
To the Editor: We applaud the article by Okie (Nov. 18 issue)1 on the increasing number of overdose deaths, since we have seen far too many patients die prematurely of opioid overdoses. One topic was missing from this article: the usefulness of providing access to naloxone to be administered by laypersons to prevent death from an opioid overdose ...
Michelle McKenzie +2 more
openaire +7 more sources
Annals of Internal Medicine, 2017
The United States is experiencing an epidemic of prescription opioid misuse, with prescription opioid overdose deaths more than quadrupling between 1999 and 2015 (14).
B. Han +5 more
semanticscholar +1 more source
The United States is experiencing an epidemic of prescription opioid misuse, with prescription opioid overdose deaths more than quadrupling between 1999 and 2015 (14).
B. Han +5 more
semanticscholar +1 more source