Results 51 to 60 of about 52,122 (312)

Assessment of Abuse Potential‐Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses

Drug Testing and Analysis, EarlyView.
In a randomized, double‐blind, placebo‐controlled study of oral dried kratom leaf powder in healthy kratom‐naive adults, no participants met the clinically meaningful opioid withdrawal threshold; abuse‐related treatment‐emergent adverse events occurred more frequently at higher doses but were generally mild and resolved without sequelae; and no serious
Marion Coe, Marilyn Huestis, Daniel Wang, Thomas Hudzik, John Bothmer, Jack Henningfield   +5 more
wiley   +1 more source

Integrated exercise program in opioid agonist therapy clinics and effect on psychological distress: study protocol for a randomized controlled trial (BAReAktiv)

Trials
Background Substance use disorder is associated with unhealthy lifestyle choices, resulting in adverse social and health consequences. People with opioid use disorder receiving opioid agonist therapy, in particular, have high morbidity and reduced ...
Einar Furulund, Tesfaye Madebo, Karl Trygve Druckrey-Fiskaaen, Jørn Henrik Vold, Mette Hegland Nordbotn, Eivin Dahl, Sindre M. Dyrstad, Torgeir Gilje Lid, Lars T. Fadnes, for the ATLAS4LAR study group   +9 more
doaj   +1 more source

Modification of κ-Opioid Receptor Agonist-Induced Antinociception by Diabetes in the Mouse Brain and Spinal Cord

Journal of Pharmacological Sciences, 2005
The supraspinal and spinal antinociceptive effects of several κ-opioid receptor agonists were examined in diabetic and non-diabetic mice using the tail-flick assay. The antinociception induced by intrathecal (i.t.), but not intracerebroventricular (i.c.v.
Masahiro Ohsawa, Junzo Kamei
doaj   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

Benzodiazepine receptors and the control of ingestive behaviour in the rat [PDF]

, 1996
When administered systemically, benzodiazepine receptor agonists have been shown to increase food intake in a number of species. Conversely, benzodiazepine receptor inverse agonists bring about reliable decreases in feeding.
Higgs, Suzanne, Higgs, S
core  

Dexmedetomidine infusions improve cardiovascular and renal function in anaesthetised, experimentally endotoxaemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee, Rachel C. Hector, Lynn Pezzanite, Eric Gilleland, Marlis L. Rezende   +4 more
wiley   +1 more source

Delta-opioid receptor endocytosis in spinal cord after dermenkephalin activation

BMC Neuroscience, 2000
Background The delta(δ)-opioid receptors belong to the G protein-coupled receptors and in vitro studies have shown that δ-opioid receptors undergo an internalization process in response to agonist stimulation.
Gastard Myriam
doaj   +1 more source

A Comparison of the Antinociceptive and Adverse Effects of the μ‐Opioid Agonist Morphine and the δ‐Opioid Agonist SNC80 [PDF]

Basic & Clinical Pharmacology & Toxicology, 2005
Abstract: δ‐Opioid receptor agonists have been postulated to induce analgesia without the adverse effects commonly associated with μ‐opioids e.g. morphine. In the present study, we evaluated the occurrence of antinociceptive and opioid‐like side effects in rats (n=5–7) treated with a single dose of subcutaneous morphine (0.01 to 40 mg/kg) or SNC80 (0 ...
Elizabeth L, Gallantine, Theo F, Meert
openaire   +2 more sources

Fatalities within seven days after equine standing sedation: A prospective, multicentre study

Equine Veterinary Journal, EarlyView.
Abstract Background Information regarding mortality associated with standing procedures in horses is sparse. Objectives To report data from >12,000 standing sedations. Study Design Confidential, observational, prospective, multicentre, cohort study.
Miguel Gozalo‐Marcilla, José I. Redondo, Polly M. Taylor, Luis Domenech, Javier Doménech, Gordon Mark Johnston, Regula Bettschart‐Wolfensberger   +6 more
wiley   +1 more source

A qualitative study of experiences with physical activity among people receiving opioid agonist therapy

Substance Abuse Treatment, Prevention, and Policy
Background Physical or mental health comorbidities are common among people with substance use disorders undergoing opioid agonist therapy. As both a preventive and treatment strategy, exercise offers various health benefits for several conditions ...
Einar Furulund, Siv-Elin Leirvåg Carlsen, Karl Trygve Druckrey-Fiskaaen, Tesfaye Madebo, Lars T Fadnes, Torgeir Gilje Lid   +5 more
doaj   +1 more source