Results 61 to 70 of about 52,122 (312)
PLoS ONE, 2020 ObjectiveThe objective of this study was to evaluate the relationship between individual characteristics and deep tissue infections in patients enrolled in opioid agonist treatment in Ontario, Canada.MethodsA retrospective cohort study was conducted on ...
Kristen A Morin +5 more
doaj +1 more source
Cellular Tolerance Induced by Chronic Opioids in the Central Nervous System
Frontiers in Systems Neuroscience, 2022 Opioids are powerful analgesics that elicit acute antinociceptive effects through their action the mu opioid receptor (MOR). However opioids are ineffective for chronic pain management, in part because continuous activation of MORs induces adaptive ...
Sweta Adhikary, John T. Williams
doaj +1 more source
The International Journal of Health Planning and Management, EarlyView.ABSTRACT This paper explores the perspectives of mental health and substance use providers who supported people released from custody during the pandemic in Ontario, Canada, with a focus on service disruptions, adaptations, and experiences. We conducted 20 in‐depth qualitative interviews and analysed these using Applied Thematic Analysis.
Lucas M. Seuren +6 more
wiley +1 more source
A lipidated TLR7/8 adjuvant enhances the efficacy of a vaccine against fentanyl in mice
npj Vaccines, 2023 Opioid use disorders (OUD) and opioid-related fatal overdoses are a public health concern in the United States. Approximately 100,000 fatal opioid-related overdoses occurred annually from mid-2020 to the present, the majority of which involved fentanyl ...
Shannon M. Miller +8 more
doaj +1 more source
Research progress on the depth of anesthesia monitoring based on the electroencephalogram
Ibrain, Volume 11, Issue 1, Page 32-43, Spring 2025.Electroencephalogram (EEG) can noninvasive, continuous, and real‐time monitor the state of brain electrical activity, and the monitoring of EEG can reflect changes in the depth of anesthesia (DOA). The development of artificial intelligence can enable anesthesiologists to extract, analyze, and quantify DOA from complex EEG data.
Xiaolan He, Tingting Li, Xiao Wang
wiley +1 more source
International Journal of Cancer, EarlyView.Chemotherapy‐induced nausea and vomiting (CINV) remains a significant clinical problem despite modern antiemetics. In particular, antiemetic strategies for emerging cancer therapies lack detailed evaluation. This randomized trial analyzed hourly CINV data for patients with early breast cancer who received either docetaxel plus cyclophosphamide (TC) or ...
Manuel Hörner +16 more
wiley +1 more source
Differential Opioid Agonist Regulation of the Mouse μ Opioid Receptor [PDF]
Journal of Biological Chemistry, 1997 Mu opioid receptors mediate the analgesia induced by morphine. Prolonged use of morphine causes tolerance development and dependence. To investigate the molecular basis of tolerance and dependence, the cloned mouse mu opioid receptor with an amino-terminal epitope tag was stably expressed in human embryonic kidney (HEK) 293 cells, and the effects of ...
A D, Blake +3 more
openaire +2 more sources
Journal of Hospital Medicine, EarlyView.Abstract Hospitalists care for patients with acute pain who have an opioid use disorder and require pain management. Hospitalists may withhold opioids for acute pain due to a variety of reasons. However, adequate pain management in patients with opioid use disorder, including with opioids, is the standard of care. This piece explains how to best manage
Anna‐Maria South +2 more
wiley +1 more source
Frontiers in Pharmacology, 2014 Opioids are intensely addictive, and cessation of their chronic use is associated with a highly aversive withdrawal syndrome. A cellular hallmark of withdrawal is an opioid sensitive protein kinase A-dependent increase in GABA transporter-1 (GAT-1 ...
Elena Elizabeth Bagley
doaj +1 more source
Access to Opioid Agonist Treatment during COVID-19 Project
, 2022 Data for methadone clinics, travel times, and census data used in "Access to Opioid Agonist Treatment during COVID-19 Public Transport Disruptions"
Higgins, Chrisopher D. +3 more
core +1 more source