Results 191 to 200 of about 22,201 (271)

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Integrating an exercise program into opioid agonist therapy: a pilot study on feasibility, fitness improvements, and participation challenges. [PDF]

Addict Sci Clin Pract
Furulund E, Carlsen SL, Alpers SE, Vold JH, Druckrey-Fiskaaen KT, Madebo T, Dyrstad SM, Lid TG, Fadnes LT.   +8 more
europepmc   +1 more source

Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso, Ronald Kadada Karyaburo, Jackson K. Mukonzo, Ene I. Ette   +3 more
wiley   +1 more source

Impact of Antiviral Therapy Scale‐Up Among People Who Inject Drugs in Scotland: Regional Evidence of Hepatitis C Virus Elimination

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Background Expansion of highly effective direct‐acting antiviral (DAA) treatment for people who inject drugs (PWID) is regarded as essential to achieve hepatitis C virus (HCV) elimination. A decade since the introduction of DAA treatment, we aimed to assess its roll‐out and associated impact in reducing HCV prevalence among PWID in Scotland ...
Norah E. Palmateer, Pantelis Samartsidis, Christopher Biggam, Andrew McAuley, Scott A. McDonald, John Dillon, Stephen T. Barclay, Samantha J. Shepherd, Rory N. Gunson, Monica Desai, Duncan McCormick, Daniela De Angelis, Matthew Hickman, Sharon J. Hutchinson   +13 more
wiley   +1 more source

The effect of fruit smoothie supplementation on psychological distress and biomarkers among people with opioid dependence receiving opioid agonist therapy: a randomized controlled trial. [PDF]

BMC Med
Javadi Arjmand E, Thomassen LM, Druckrey-Fiskaaen KT, Furulund E, Vold JH, Madebo T, Blomhoff R, Daltveit JT, Henriksen HB, Chalabianloo F, Johansen KA, Lid TG, Fadnes LT, ATLAS4LAR study group.   +13 more
europepmc   +1 more source

Oromucosal Administration of a Cannabidiol‐Enriched Cannabis sp. Extract for 2 Weeks Moderately Reduces Cold Hyperalgesia in Rats With Neuropathic Pain

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Chronic neuropathic pain (CNP) involves complex interactions between resident and peripheral immune cells, as well as modulation of the endocannabinoid system. Cannabis‐based products have emerged as promising therapeutic options, but their effects on immune cells remain unclear.
Raquel Maria Pereira Campos, Luciana Conde, Andrey Aguiar, Luzia Sampaio, Ricardo Augusto de Melo Reis, Pedro Moreno Pimentel‐Coelho   +5 more
wiley   +1 more source

Associations between happiness with social factors and opioid agonist therapy among people who inject drugs. [PDF]

Sci Rep
Guerra CL, Vold JH, Aas CF, Chalabianloo F, Løberg EM, Johansson KA, Fadnes LT.   +6 more
europepmc   +1 more source

Effects of Selective Sphingosine‐1‐Phosphate Receptor 1 Agonist, TRV045, on Evoked Pain Tests: An Exploratory, Four‐Way Cross‐Over Study in Healthy Volunteers

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Introduction Preclinical evidence suggests that dysregulation of the ceramide‐sphingosine‐1‐phosphate (S1P) axis may have analgesic properties. However, currently approved S1PR1 modulators such as fingolimod are hindered for this indication as they induce lymphopenia.
Wouter A. Bakker, P. Eijsvogel, Erica S. Klaassen, Jessica Kim, Ruihua Chen, Mark A. Demitrack, Albert Dahan, Marieke Niesters, Hemme J. Hijma, Geert Jan Groeneveld   +9 more
wiley   +1 more source

Case series: Symptom-inhibited fentanyl induction (SIFI) onto treatment-dose opioid agonist therapy in a community setting. [PDF]

Am J Addict
Azar P, Kim JJ, Davison R, Barazanci Z, Ignaszewski MJ, Wong JSH, Machado J, Harris M, Krausz M, Mathew N, Herring A, Montaner JSG.   +11 more
europepmc   +1 more source

Prophylactic Dexmedetomidine Reduces Junctional Ectopic Tachycardia and Facilitates Postoperative Recovery in Pediatric Cardiac Surgery: A Systematic Review and Meta‐Analysis of Prospective Trials

Pediatric Anesthesia, Volume 36, Issue 7, Page 767-777, July 2026.
ABSTRACT Objective To evaluate the efficacy and safety of prophylactic dexmedetomidine in preventing Junctional Ectopic Tachycardia (JET) and its impact on postoperative recovery in pediatric congenital heart surgery, restricting analysis to prospective trials. Methods We systematically searched PubMed, Scopus, and CENTRAL through October 16, 2025, for
Michelle Singh, Arjun Anilkumar, Rohit Vondivillu Srinivasan, Jasim Abdul Jabbar, Naghul Malaichamy, Rethin Jayaraman   +5 more
wiley   +1 more source