Abstract Background Growing evidence indicates that paternal condition significantly influences pregnancy outcomes and offspring health. However, assessing the safety of paternal drug exposure via randomized controlled trials poses ethical challenges, and relevant clinical studies consume a lot of resources to evaluate only a few drugs.
Yanbin Zeng, Wanlong Lin, Wei Zhuang
wiley +1 more source
Impact of opioid analgesics on survival in cancer patients receiving immune checkpoint inhibitors. [PDF]
Kavgaci G+8 more
europepmc +1 more source
The Effects of Gum Chewing in the Postoperative‐Period: A Systematic Review and Meta‐Analysis
Meta‐analysis supports the use of chewing gum as a successful intervention to relieve postoperative ileus. ABSTRACT Objective Postoperative ileus (POI) is a transient impairment of gastrointestinal motility occurring after surgery. Patients with POI can suffer from complications such as increased risk of nosocomial infections, overall mortality risk ...
Calandra Li+6 more
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Improved Opioid Analgesic Effect Following Opioid Dose Reduction [PDF]
Yakov Vorobeychik+3 more
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Change in median eGFR from baseline; eGFR measured as mL/min/1.73 m2. ABSTRACT Background Non‐steroidal anti‐inflammatory drugs (NSAIDs) are fundamental for multimodal analgesic therapy, but are traditionally avoided in renally impaired patients. We aim to show NSAIDs can be safely administered to arthroplasty patients with a pre‐operative estimated ...
Liam T. A. Fernando‐Canavan+3 more
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Respiratory Effects of Benzodiazepine in Patients with Advanced-Stage Cancer Receiving Opioid Analgesics: A Prospective Observational Study. [PDF]
Yoshimura A+5 more
europepmc +1 more source
In a metabolomics study of over 200 metabolites in 1721 fertile‐aged women, we found that current use of combined oral contraceptives (COC), especially third‐generation and other COCs, is associated with altered levels of several metabolic measures compared to nonuse of hormonal contraception or to use of a levonorgestrel intrauterine device (LNG‐IUD).
Elena Toffol+7 more
wiley +1 more source
Alleged Breaches of “Standards of Medical Care” in a Patient Overdose Death Possibly Related to Chronic Opioid Analgesic Therapy, Application of the Controlled Substances Model Guidelines: Case Report: Table 1 [PDF]
David A. Fishbain+4 more
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Differences in pain, bleeding, and satisfaction during medical abortion at very early gestations
Very early medical abortion that is, abortion before confirmation of pregnancy location, is both safe and efficient. Compared to medical abortion after ultrasound visualization of an embryo, it is associated with less pain, shorter bleeding duration, and higher satisfaction. Thus, also patient‐oriented outcomes favor early abortion treatment.
Frida Gyllenberg+10 more
wiley +1 more source
Comparative efficacy of opioid and non-opioid analgesics in labor pain management: A network meta-analysis. [PDF]
Chen Y, Chen H, Yuan C.
europepmc +1 more source