Results 261 to 270 of about 52,732 (301)
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Mechanism of opioid tolerance and dependence
Neuropeptides, 1984Abstract Tolerance and dependence have been proposed to be expressed by neurones carrying opiate receptors. In fact, the cellular aspect of opiate dependence defines the post-recognition site of the opiate receptor system as being mainly involved in the mechanism responsible for these phenomena (1,2).
R, Schulz, M, Wüster
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Buprenorphine for the treatment of opioid dependence
American Journal of Health-System Pharmacy, 2007The clinical issues surrounding the use of buprenorphine for the treatment of opioid dependence are reviewed.Opioids continue to be some of the most frequently reported prescription medications in substance abuse- related cases. A semisynthetic derivative of thebaine, buprenorphine hydrochloride is a partial mu-opioid receptor agonist and kappa ...
Lisa A, Boothby, Paul L, Doering
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Hypogonadism in an opioid dependent man
Irish Journal of Psychological Medicine, 2011AbstractWe describe here the case of a 45-year-old man with a chronic history of heroin abuse who has received methadone maintenance therapy for 12 years. At admission, on this occasion, for stabilisation on methadone, he reported a two-year history of painful gynaecomastia and testicular atrophy.
Nnamdi, Nkire +2 more
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Opioid antagonists for alcohol dependence
Cochrane Database of Systematic Reviews, 2010Alcohol dependence belongs to the globally leading health risk factors. Therapeutic success of psychosocial programs for relapse prevention is moderate and could be increased by an adjuvant treatment with the opioid antagonists naltrexone and nalmefene.To determine the effectiveness and tolerability of opioid antagonists in the treatment of alcohol ...
Susanne, Rösner +5 more
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Opioid antagonists and butorphanol dependence
Pharmacology Biochemistry and Behavior, 1993Butorphanol has been known to act on mu-, delta-, and kappa-opioid receptors, mu- and possibly delta-receptors are thought to mediate morphine dependence. Relative to morphine, butorphanol has a higher affinity for mu- and delta-receptors. In the present study, beta-funaltrexamine (beta-FNA) and naltrindole (NTI) (nonequilibrium mu- and delta ...
S P, Jaw, B, Hoskins, I K, Ho
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Buprenorphine in the treatment of opioid dependence
European Neuropsychopharmacology, 2004Buprenorphine has become of increasing interest to be an alternative to methadone in the treatment of heroin addicts. The aim of the paper is to review, from a clinical perspective, the current status of what is known about the pharmacology of buprenorphine, with a particular emphasis on the issues of maintenance therapy in heroin addiction.
Eugen, Davids, Markus, Gastpar
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BMJ clinical evidence, 2016
Dependence on opioids is a multifactorial condition involving genetic and psychosocial factors. There are three approaches to treating opioid dependence. Stabilisation is usually by opioid substitution treatments, and aims to ensure that the drug use becomes independent of mental state (such as craving and mood) and independent of circumstances (such ...
Jacinta, O'Shea +2 more
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Dependence on opioids is a multifactorial condition involving genetic and psychosocial factors. There are three approaches to treating opioid dependence. Stabilisation is usually by opioid substitution treatments, and aims to ensure that the drug use becomes independent of mental state (such as craving and mood) and independent of circumstances (such ...
Jacinta, O'Shea +2 more
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Opioid modulators for alcohol dependence
Expert Opinion on Investigational Drugs, 2011Studies have shown that opioid antagonists like naltrexone are efficient in reducing heavy drinking. The neurobiological mechanism by which opioid modulators affect drinking behavior is based on the strong connection between the endogenous opioid system, the dopamine system and the influence of the CNS stress response.This review provides an overview ...
Thomas, Hillemacher +4 more
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Introduction: Landscape of Opioid Dependence
Journal of Managed Care Pharmacy, 2010The use of opioids for chronic noncancer pain increased 222% from 1992 to 2002. Opioid dependence has also increased significantly, leading to a burden on patients, employers, insurers, society, and the entire health care system. It is imperative that opioid dependence is addressed and treated properly, in order to return patients to being productive ...
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Opioid antagonists for alcohol dependence
2002Opioid antagonists can decrease alcohol consumption in animals. Their harms and benefits have been examined in many clinical trials.To determine the effectiveness of opioid antagonists in attenuating or preventing the recommencement of alcohol consumption in patients with alcohol dependence in comparison to placebo, other medications and psychosocial ...
M, Srisurapanont, N, Jarusuraisin
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