Results 161 to 170 of about 302,501 (282)

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2723-2740, August 2026.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Beyond access: improving real-world naloxone use to address the opioid overdose epidemic. [PDF]

Int J Emerg Med
Neuenschwander J, Wilkerson RG, Weiner SG.   +2 more
europepmc   +1 more source

Increasing the reporting of adverse drug reaction‐related hospitalizations using an ICD‐10‐based identification workflow: A multicentre study from Switzerland

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2937-2948, August 2026.
Background Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under‐reporting remains widespread. We tested a novel method to increase reporting of ADR‐related hospitalizations.
Georgia Anita Weber, Sophie‐Charlotte Bartel, Michael Boch, Christoph Rosen, Michael Bodmer, Balthasar Luzius Hug, Thomas Stammschulte, Patrick E. Beeler   +7 more
wiley   +1 more source

Characterization of patients declining to participate in opioid overdose prevention clinical research in an emergency department setting. [PDF]

J Subst Use Addict Treat
Ward RC, Brigham G, Barth KS, Jennings LK, Papa CE, Smith AJ, Litwin AH, Haynes L, Matheson T, Sonne S, Heineck L, McClure EA.   +11 more
europepmc   +1 more source

Mortality Trend in Patients With Heart Failure and Psychoactive Substance Abuse in the United States—Pre‐ and Post‐COVID‐19 Pandemic Perspective (1999−2023)

Clinical Cardiology, Volume 49, Issue 8, August 2026.
From 1999 to 2023, national HF‐substance abuse‐related mortality rates in adults rose over 10‐fold, disproportionately affecting males, older adults, and NH White and NH Black populations. Geographically, nonmetropolitan areas and the Midwestern/Northwestern regions saw the highest burden, signaling an urgent need for integrated cardiovascular and ...
Emad Uddin Sajid, Ayesha Irfan, Muhammad Kashan, Syed Rayyan Ahmed, Muhammad Hasnain Azeem, Tooba Ali, Mabel Waqar, Muneeba Khan, Erum Shahzadi Malik, Md Ariful Haque   +9 more
wiley   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, Volume 18, Issue 8, Page 1097-1113, August 2026.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

Things We Do for No Reason™: Withholding opioids among patients with acute pain and opioid use disorder

Journal of Hospital Medicine, Volume 21, Issue 8, Page 928-931, August 2026.
Visual Abstract Abstract Hospitalists care for patients with acute pain who have an opioid use disorder and require pain management. Hospitalists may withhold opioids for acute pain due to a variety of reasons. However, adequate pain management in patients with opioid use disorder, including with opioids, is the standard of care.
Anna‐Maria South, Susan L. Calcaterra, Marlene Martin   +2 more
wiley   +1 more source

Area-specific autoencoder spatiotemporal graph neural networks for opioid overdose death prediction. [PDF]

JAMIA Open
Chen X, Yin C, Myers JV, Slover B, Thomas N, Marks C, Kim J, Fernández S, Whitley P, Fareed N, Zhang P.   +10 more
europepmc   +1 more source

Geographic Disparities in the Opioid Overdose Crisis: Access, Treatment, and Mortality. [PDF]

Cureus
Al-Awadhi AA, Vegiraju SM.
europepmc   +1 more source

Error Traps in Pediatric Neuromuscular Block

Pediatric Anesthesia, Volume 36, Issue 8, Page 887-898, August 2026.
ABSTRACT Background Neuromuscular blocking agents are essential for safe pediatric anesthesia but remain a frequent source of preventable morbidity when misused, inadequately monitored, or incompletely reversed. Children, particularly neonates and infants, are especially vulnerable to residual neuromuscular block due to developmental pharmacological ...
Gabriel Soares de Sousa, Debra Faulk, Vinicius Caldeira Quintao, Niekoo Abbasian, Hans D. de Boer, Ricardo Vieira Carlos   +5 more
wiley   +1 more source