Results 241 to 250 of about 1,102,643 (357)
Orphanin FQ/nociceptin: an endogenous peptide agonist for the orphan opioid receptor
, 1998 David G. Lambert, David K. Grandy
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Colloquium C10: Opioid Peptides: Normal & Pathologic Signaling Mechanisms in Neurons & Glia [PDF]
, 2003 openalex +1 more source
Arrestin‐centred interactions at the membrane and their conformational determinants
British Journal of Pharmacology, Volume 182, Issue 14, Page 3135-3150, July 2025.Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood +3 more
wiley +1 more source
Opioid peptides in cerebrospinal fluid-methods for analysis and their significance in the clinical perspective [PDF]
, 2004 Fred Nyberg
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Surface acoustic wave technology as a tool for functional characterization of new compounds [PDF]
, 2012 Bracke, Nathalie +2 more
core +1 more source
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Allosterism in the adenosine A2A and cannabinoid CB2 heteromer
British Journal of Pharmacology, Volume 182, Issue 14, Page 3371-3384, July 2025.Abstract Background and Purpose Allosterism is a regulatory mechanism for GPCRs that can be attained by ligand‐binding or protein–protein interactions with another GPCR. We have studied the influence of the dimer interface on the allosteric properties of the A2A receptor and CB2 receptor heteromer.
Claudia Llinas del Torrent +7 more
wiley +1 more source
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
British Journal of Pharmacology, Volume 182, Issue 14, Page 3225-3248, July 2025.G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel +11 more
wiley +1 more source