Results 1 to 10 of about 10,153 (221)

The Role of Endogenous Beta-Endorphin and Enkephalins in the Crosstalk Between Ethanol and Morphine [PDF]

Pharmaceuticals
Background: There is clinical concern about the combined use of alcohol and opiates. Several lines of evidence support an interaction between alcohol and the endogenous opioid system.
Andy Tseng, Syed Muzzammil Ahmad, Abdul Hamid, Kabirullah Lutfy   +3 more
doaj   +2 more sources

Anxiety- and depressive-like responses and c-fos activity in preproenkephalin klockout mice: Oversensitivity hypothesis of enkephalin deficit-induced posttraumatic stress disorder [PDF]

Journal of Biomedical Science, 2010
The present study used the preproenkephalin knockout (ppENK) mice to test whether the endogenous enkephalins deficit could facilitate the anxiety- and depressive-like symptoms of posttraumatic stress disorder (PTSD).
Shyu Bai-Chuang, Chen Tsung-Chieh, Kung Jen-Chuang, Hsiao Sigmund, Huang Andrew   +4 more
doaj   +3 more sources

The Involvement of Endogenous Enkephalins in Glucose Homeostasis [PDF]

Biomedicines, 2023
Obesity has nearly tripled since 1975 and is predicted to continue to escalate. The surge in obesity is expected to increase the risk of diabetes type 2, hypertension, coronary artery disease, and stroke.
Vanessa Escolero, Laica Tolentino, Abdul Bari Muhammad, Abdul Hamid, Kabirullah Lutfy   +4 more
doaj   +2 more sources

Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice [PDF]

eLife
Enkephalins are opioid peptides that modulate analgesia, reward, and stress. In vivo detection of enkephalins remains difficult due to transient and low endogenous concentrations and inherent sequence similarity.
Marwa O Mikati, Petra Erdmann-Gilmore, Rose Connors, Sineadh M Conway, Jim Malone, Justin Woods, Robert W Sprung, Reid R Townsend, Ream Al-Hasani   +8 more
doaj   +2 more sources

Enkephalins and Pain Modulation: Mechanisms of Action and Therapeutic Perspectives [PDF]

Biomolecules
Enkephalins, a subclass of endogenous opioid peptides, play a pivotal role in pain modulation. Enkephalins primarily exert their effects through opioid receptors located widely throughout both the central and peripheral nervous systems.
Mario García-Domínguez
doaj   +2 more sources

Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice [PDF]

eLife
CD4+CD25+Foxp3+ regulatory T cells (Treg) have been implicated in pain modulation in various inflammatory conditions. However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear.
Nicolas Aubert, Madeleine Purcarea, Julien Novarino, Julien Schopp, Alexis Audibert, Wangtianrui Li, Marie Fornier, Léonie Cagnet, Marie Naturel, Armanda Casrouge, Marie-Caroline Dieu-Nosjean, Nicolas Blanchard, Gilles Dietrich, Cedric Peirs, Gilles Marodon   +14 more
doaj   +2 more sources

Exploiting the angiotensin-converting enzyme pathway to augment endogenous opioid signaling [PDF]

Communications Biology
Angiotensin Converting Enzyme (ACE) impacts hemodynamics by regulating the conversion of angiotensin I to the vasoconstricting angiotensin II. We recently identified a non-canonical central role of ACE in the degradation of enkephalin heptapeptide, Met ...
Prakashkumar Dobariya, Jessica Williams, Filip Hanak, Patrick E. Rothwell, Swati S. More   +4 more
doaj   +2 more sources

Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling. [PDF]

PLoS Pathogens
By eliciting immune activation in the digestive tract, intestinal pathogens may perturb gut homeostasis. Some gastrointestinal infections can indeed increase the risk of developing post-infectious irritable bowel syndrome (PI-IBS).
Alexis Audibert, Xavier Mas-Orea, Léa Rey, Marcy Belloy, Emilie Bassot, Louise Battut, Gilles Marodon, Frederick Masson, Matteo Serino, Nicolas Cenac, Gilles Dietrich, Chrystelle Bonnart, Nicolas Blanchard   +12 more
doaj   +2 more sources

Racecadotril induced bilateral uveal effusion: a case report [PDF]

BMC Ophthalmology
Background Uveal effusion is a sight threatening condition, due to possible acute angle-closure glaucoma and maculopathy. We present a case of bilateral uveal effusion after taking racecadotril, an enkephalinase inhibitor used as a medical treatment for ...
Jona Callaert, Pieter-Paul Schauwvlieghe, Joachim Van Calster   +2 more
doaj   +2 more sources

Role of enkephalin derivative in promoting wound healing and scar remodeling via increased epidermal growth factor in a mouse model [PDF]

Archives of Aesthetic Plastic Surgery, 2023
Background Enkephalin, an endogenous neuropeptide, binds to the delta (δ) opioid receptor and exerts an antinociceptive effect. Recent studies have suggested that neuropeptides might effectuate cutaneous wound healing.
Sun Eung Kim, Yu Jin Kim, Young Woo Cheon   +2 more
doaj   +1 more source