Results 21 to 30 of about 10,153 (221)

Proenkephalin deletion in hematopoietic cells induces intestinal barrier failure resulting in clinical feature similarities with irritable bowel syndrome in mice

Communications Biology, 2023
Opioid-dependent immune-mediated analgesic effects have been broadly reported upon inflammation. In preclinical mouse models of intestinal inflammatory diseases, the local release of enkephalins (endogenous opioids) by colitogenic T lymphocytes alleviate
Xavier Mas-Orea, Lea Rey, Louise Battut, Cyrielle Bories, Camille Petitfils, Anne Abot, Nadine Gheziel, Eve Wemelle, Catherine Blanpied, Jean-Paul Motta, Claude Knauf, Frederick Barreau, Eric Espinosa, Meryem Aloulou, Nicolas Cenac, Matteo Serino, Lionel Mouledous, Nicolas Fazilleau, Gilles Dietrich   +18 more
doaj   +1 more source

Central administration of human opiorphin alleviates dextran sodium sulfate-induced colitis in mice through activation of the endogenous opioid system

Frontiers in Pharmacology, 2022
The opioid system plays a crucial role in maintaining gastrointestinal homeostasis. Endogenous opioid peptide enkephalins have anti-inflammatory effect and participate in the treatment of inflammatory bowel diseases (IBDs).
Pan Luo, Xuelin Li, Yuan Gao, Zhengjun Chen, Quanwei Zhang, Zhimin Wang, Xiaozhu Tian   +6 more
doaj   +1 more source

Challenges and new opportunities for detecting endogenous opioid peptides in reward

Addiction Neuroscience, 2022
The endogenous opioid peptide system, comprised of enkephalins, endorphins, dynorphins, and nociceptin, is a highly complex neurobiological system. Opioid peptides are derived from four precursor molecules and undergo several processing events yielding ...
Sineadh M. Conway, Marwa O. Mikati, Ream Al-Hasani   +2 more
doaj   +1 more source

Enkephalinase activity is modified and correlates with fatty acids in frontal cortex depending on fish, olive or coconut oil used in the diet

Endocrine Regulations, 2019
Objective. Enkephalins are neuropeptides involved in functions such as pain modulation and/ or cognitive processes. It has been reported that dietary fat modifies enkephalins in the brain.
Segarra Ana B., Prieto Isabel, Martinez-Canamero Magdalena, Ruiz-Sanz Jose-Ignacio, Ruiz-Larrea M. Begona, De Gasparo Marc, Banegas Inmaculada, Zorad Stefan, Ramirez-Sanchez Manuel   +8 more
doaj   +1 more source

A MATERIAL FULL OF PROMISES:Hg1−XCdXTe - MERCURY CADMIUM TELLURID

Journal of Engineering Science (Chişinău), 2023
In recent decades’ doctors and scientists have intensively researched the effect of infrared applications. The rays of infrared devices penetrate the body to a depth of about 5 cm and provide a pleasant warmth, stimulating blood circulation and
BĂJENESCU, Titu-Marius I.
doaj   +1 more source

Neuropharmacological targets for drug action in vestibular sensory pathways [PDF]

, 2017
The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that ...
Jones, Timothy A, Lee, Choongheon
core   +3 more sources

Involvement of the Opioid Peptide Family in Cancer Progression

Biomedicines, 2023
Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating angiogenesis/lymphangiogenesis.
Manuel Lisardo Sánchez, Francisco D. Rodríguez, Rafael Coveñas   +2 more
doaj   +1 more source

Proenkephalin and risk of developing chronic kidney disease:The Prevention of Renal and Vascular End-stage Disease study [PDF]

, 2018
BACKGROUND: Proenkephalin (pro-ENK) was recently found to be associated with low estimated glomerular filtration rate (eGFR). The association of pro-ENK with urinary albumin excretion (UAE), another marker for chronic kidney disease (CKD), has not been ...
Bakker, Stephan J. L., Bergmann, Andreas, de Boer, Rudolf A., Gansevoort, Ron T., Hartmann, Oliver, Joosten, Michel M., Kieneker, Lyanne M., Struck, Joachim   +7 more
core   +7 more sources

Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

Frontiers in Cellular Neuroscience, 2015
The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle.
Daniil eSarkisyan, Muhammad Z. Hussain, Hiroyuki eWatanabe, Olga eKononenko, Olga eKononenko, Igor eBazov, Xing Wu eZhou, Olga eYamskova, Oleg eKrishtal, Victor M. Karpyak, Tatiana eYakovleva, Georgy eBakalkin   +11 more
doaj   +1 more source

Modulation of Neurally Mediated Vasodepression and Bradycardia by Electroacupuncture through Opioids in Nucleus Tractus Solitarius. [PDF]

, 2018
Stimulation of vagal afferent endings with intravenous phenylbiguanide (PBG) causes both bradycardia and vasodepression, simulating neurally mediated syncope.
Fu, Liang-Wu, Guo, Zhi-Ling, Longhurst, John C, Tjen-A-Looi, Stephanie C   +3 more
core   +3 more sources