Results 21 to 30 of about 6,613 (165)

Role of enkephalin derivative in promoting wound healing and scar remodeling via increased epidermal growth factor in a mouse model [PDF]

Archives of Aesthetic Plastic Surgery, 2023
Background Enkephalin, an endogenous neuropeptide, binds to the delta (δ) opioid receptor and exerts an antinociceptive effect. Recent studies have suggested that neuropeptides might effectuate cutaneous wound healing.
Sun Eung Kim, Yu Jin Kim, Young Woo Cheon   +2 more
doaj   +1 more source

CARDIOPROTECTIVE EFFECT OF ENKEPHALINS UNDER IMMOBILIZATION STRESS [PDF]

Biotechnologia Acta, 2022
Objective: The aim of this study was to investigate the cardioprotective effect of dalargin, a synthetic leu-enkephalin. Methods: The induction of myocardial infarction in rats, which were kept on a diet with excess fat and calcium/sodium salts for ...
І. J. Shcheniavskyi
doaj   +1 more source

A “Drug-Dependent” Immune System Can Compromise Protection against Infection: The Relationships between Psychostimulants and HIV

Viruses, 2021
Psychostimulant use is a major comorbidity in people living with HIV, which was initially explained by them adopting risky behaviors that facilitate HIV transmission.
María Amparo Assis, Pedro Gabriel Carranza, Emilio Ambrosio   +2 more
doaj   +1 more source

CD206+/MHCII− macrophage accumulation at nerve injury site correlates with attenuation of allodynia in TASTPM mouse model of Alzheimer's disease

Brain, Behavior, & Immunity - Health, 2022
Chronic pain is undertreated in people with Alzheimer's disease (AD) and better understanding of the underlying mechanisms of chronic pain in this neurodegenerative disease is essential.
Rita Silva, George Sideris-Lampretsas, Sarah Fox, Lynda Zeboudj, Marzia Malcangio   +4 more
doaj   +1 more source

Anti-Inflammatory Effect of Homo- and Heterodimers of Natural Enkephalinase Inhibitors in Experimental Colitis in Mice

Molecules, 2020
Background: the pharmacological treatment and/or maintenance of remission in inflammatory bowel diseases (IBDs) is currently one of the biggest challenges in the field of gastroenterology.
Małgorzata Sobocińska, Maciej Salaga, Jakub Fichna, Elżbieta Kamysz   +3 more
doaj   +1 more source

Cellular Profiles of Prodynorphin and Preproenkephalin mRNA-Expressing Neurons in the Anterior Olfactory Tubercle of Mice

Frontiers in Neural Circuits, 2022
The olfactory tubercle (OT) is a striatal region that receives olfactory inputs. mRNAs of prodynorphin (Pdyn) and preproenkephalin (Penk), precursors of dynorphins and enkephalins, respectively, are strongly expressed in the striatum. Both produce opioid
Ayako Maegawa, Ayako Maegawa, Koshi Murata, Koshi Murata, Kazuki Kuroda, Kazuki Kuroda, Shigeharu Fujieda, Yugo Fukazawa, Yugo Fukazawa, Yugo Fukazawa   +9 more
doaj   +1 more source

The effect of ethanol consumption on the carboxypeptidase E activity on different age rats posterity

Известия высших учебных заведений. Поволжский регион: Естественные науки, 2022
Background. The consumption of ethanol by dams strongly effects the offspring’s body, its health both at birth and throughout life. This effect has a particularly strong effect on the functioning of various regulatory systems, in particular ...
A.N. Vernigora, N.V. Volkova
doaj   +1 more source

Proenkephalin deletion in hematopoietic cells induces intestinal barrier failure resulting in clinical feature similarities with irritable bowel syndrome in mice

Communications Biology, 2023
Opioid-dependent immune-mediated analgesic effects have been broadly reported upon inflammation. In preclinical mouse models of intestinal inflammatory diseases, the local release of enkephalins (endogenous opioids) by colitogenic T lymphocytes alleviate
Xavier Mas-Orea, Lea Rey, Louise Battut, Cyrielle Bories, Camille Petitfils, Anne Abot, Nadine Gheziel, Eve Wemelle, Catherine Blanpied, Jean-Paul Motta, Claude Knauf, Frederick Barreau, Eric Espinosa, Meryem Aloulou, Nicolas Cenac, Matteo Serino, Lionel Mouledous, Nicolas Fazilleau, Gilles Dietrich   +18 more
doaj   +1 more source

Cardiovascular effects of enkephalins [PDF]

, 1987
Enkephalins and their receptors are found in neurons and nerve terminals known to be involved in central cardiovascular control as well as the peripheral sympathetic and parasympathetic systems.
Feuerstein, G., Sirén, Anna-Leena
core   +2 more sources

Delta opioid receptors on nociceptive sensory neurons mediate peripheral endogenous analgesia in colitis

Journal of Neuroinflammation, 2022
Background Inflammatory visceral pain is endogenously controlled by enkephalins locally released by mucosal CD4+ T lymphocytes in mice. The present study aimed at identifying opioid receptor(s) expressed on nociceptive sensory nerves involved in this ...
Xavier Mas-Orea, Lilian Basso, Catherine Blanpied, Claire Gaveriaux-Ruff, Nicolas Cenac, Gilles Dietrich   +5 more
doaj   +1 more source