Results 41 to 50 of about 10,240 (222)

THE DISTRIBUTION OF METHIONINE‐ENKEPHALIN AND LEUCINE‐ENKEPHALIN IN THE BRAIN AND PERIPHERAL TISSUES [PDF]

British Journal of Pharmacology, 1977
A method is described for the rapid extraction of opioid peptides from the brain and other tissues. The method is based on acid extraction of tissues followed by adsorption of the extract onto Amberlite XAD‐2 resin. Elution with methanol separates the enkephalins and α‐endorphin from β‐endorphin.Over 90% of the opioid peptide activity isolated from ...
J, Hughes, H W, Kosterlitz, T W, Smith
openaire   +4 more sources

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons [PDF]

, 2006
Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process.
Ambrose-Lanci, L. M., Gallagher, S. M., Unterwald, E. M., Van Bockstaele, E. J.   +3 more
core   +2 more sources

The competitive interplay of 12‐oxophytodienoic acid (OPDA), protein thiols, and glutathione

The FEBS Journal, EarlyView.
12‐Oxophytodienoic acid (OPDA) is a phytohormone involved in plant growth and stress defense. Due to its cyclopentenone moiety, OPDA can form Michael adducts with thiol‐containing compounds such as glutathione and cysteine residues of proteins, resulting in alterations of the cellular redox regulatory network.
Madita Knieper, Ruben Schwarz, Lara Vogelsang, Jens Sproß, Armağan Kaya, Maike Bittmann, Harald Gröger, Andrea Viehhauser, Karl‐Josef Dietz   +8 more
wiley   +1 more source

Double labelling immunohistochemical characterization of autonomic sympathetic neurons innervating the sow retractor clitoridis muscle [PDF]

, 2008
Retrograde neuronal tracing and immunohistochemical methods were used to define the neurochemical content of sympathetic neurons projecting to the sow retractor clitoridis muscle (RCM). Differently from the other smooth muscles of genital organs, the RCM
Acone, Franca, Bo Minelli, Luisa, Botti, Maddalena, Gazza, Ferdinando, Palmieri, Giovanni, Panu, Rino, Ragionieri, Luisa   +6 more
core  

Racecadotril for acute diarrhoea in children: systematic review and meta-analyses [PDF]

, 2015
OBJECTIVE Racecadotril is an antisecretory agent that can prevent fluid/electrolyte depletion from the bowel as a result of acute diarrhoea, without affecting intestinal motility. An up-to-date systematic review is indicated to summarise the evidence on
Alam, Alvarez Calatayud, Anthony Akobeng, Bruzzese, Cojocaru, Cézard, Eberlin, Freedman, Gill, Guarino, Gutierrez Castrellon, Higgins, Higgins, Huighebaert, Lehert, Mehta, Melendez Garcia, Morris Gordon, Nataro, Pieścik-Lech, Pitkin, Rao, Rautenberg, Riddle, Salazar-Lindo, Sands, Santos, Savitha, Szajewska, Tebruegge, Tormo, Turck   +31 more
core   +1 more source

Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats

Neurogastroenterology &Motility, Volume 38, Issue 5, May 2026.
Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao, Yan‐lin Liu, Xiao‐mei Wang, Kai Cheng, Qing‐yu Tu, Fei Dai, Xi‐bing Yang   +6 more
wiley   +1 more source

Anesthetic Mechanism of Myeloacupuncture in Joints аnd Spine Pathology

Bolʹ, Sustavy, Pozvonočnik, 2015
The article presents a literature review on the application of such method of reflexotherapy acupuncture as myeloacupuncture used in the pathology of the peri­pheral joints and spine.
V.V. Yakovlenko, V.M. Sokrut, O.V. Syniachenko   +2 more
doaj   +1 more source

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes [PDF]

, 2017
Venom systems have evolved on multiple occasions across the animal kingdom, and they can act as key adaptations to protect animals from predators. Consequently, venomous animals serve as models for a rich source of mimicry types, as non-venomous ...
Amanda Nouwens, Anthony Romilio, Bryan G. Fry, Gavan M. Cooke, Gregory C. Bird, Han Han, Irina Vetter, Ivan Koludarov, Ivo Que, James Dobson, Jeroen C. Visser, Jordan Debono, Karen L. Cheney, Karine Mardon, Kate Baumann, Louise van der Weerd, Michael K. Richardson, Michael Morgan, Nicholas R. Casewell, Sanjaya Kuruppu, Simon C. Wagstaff, Syed A. Ali, Vera Weisbecker, Wayne C. Hodgson   +23 more
core   +6 more sources

Clinical significance of exercise‐induced hypoalgesia in individuals with temporomandibular disorders and neck pain: A clinical trial protocol

Experimental Physiology, Volume 111, Issue 6, Page 2777-2786, 1 June 2026.
Abstract Evidence reports positive effects of neck motor control and aerobic exercises (AEs) to improve pain in individuals with temporomandibular disorders (TMD) and neck pain. A single bout of exercise typically leads to an increase in pain thresholds up to 30 min post‐exercise, known as exercise‐induced hypoalgesia (EIH).
Luiz Felipe Tavares, Ana Izabela Sobral de Oliveira‐Souza, Vladimir Aron, Ana Beatriz Oliveira, Henrik Bjarke Vaegter, Susan Armijo‐Olivo   +5 more
wiley   +1 more source