Results 11 to 20 of about 10,240 (222)

CARDIOPROTECTIVE EFFECT OF ENKEPHALINS UNDER IMMOBILIZATION STRESS [PDF]

open access: yesBiotechnologia Acta, 2022
Objective: The aim of this study was to investigate the cardioprotective effect of dalargin, a synthetic leu-enkephalin. Methods: The induction of myocardial infarction in rats, which were kept on a diet with excess fat and calcium/sodium salts for ...
І. J. Shcheniavskyi
doaj   +1 more source

A “Drug-Dependent” Immune System Can Compromise Protection against Infection: The Relationships between Psychostimulants and HIV

open access: yesViruses, 2021
Psychostimulant use is a major comorbidity in people living with HIV, which was initially explained by them adopting risky behaviors that facilitate HIV transmission.
María Amparo Assis   +2 more
doaj   +1 more source

CD206+/MHCII− macrophage accumulation at nerve injury site correlates with attenuation of allodynia in TASTPM mouse model of Alzheimer's disease

open access: yesBrain, Behavior, & Immunity - Health, 2022
Chronic pain is undertreated in people with Alzheimer's disease (AD) and better understanding of the underlying mechanisms of chronic pain in this neurodegenerative disease is essential.
Rita Silva   +4 more
doaj   +1 more source

Exposure to exogenous enkephalins disrupts reproductive development in the Eastern lubber grasshopper, Romalea microptera (Insecta: Orthoptera). [PDF]

open access: yesPLoS ONE, 2012
Enkephalins play a major role in reproductive physiology in crustaceans; however their role in reproductive development in insects is largely unknown. We investigated the effect of exposure to exogenous leucine-enkephalin (Leu-Enk), methionine-enkephalin
Sandeep Kumar   +4 more
doaj   +1 more source

‘Acetaldehyde‐enkephalins’: elucidation of the structure of the acetaldehyde adducts of methionine‐enkephalin and leucine‐enkephalin [PDF]

open access: yesFEBS Letters, 1980
The two major endogenous opioid pentapeptides, methionine-enkephalin and leucine-enkephalin [ 1,2] rapidly react with acetaldehyde, under very mild conditions, to give an ‘acetaldehyde-enkephalin’ adduct, referred to as ‘acetaldehyde-enkephalin [Met’] and ‘acetaldehyde-enkephalin [Leu”], respectively 231.
Summers, Michael C.   +2 more
openaire   +5 more sources

Anti-Inflammatory Effect of Homo- and Heterodimers of Natural Enkephalinase Inhibitors in Experimental Colitis in Mice

open access: yesMolecules, 2020
Background: the pharmacological treatment and/or maintenance of remission in inflammatory bowel diseases (IBDs) is currently one of the biggest challenges in the field of gastroenterology.
Małgorzata Sobocińska   +3 more
doaj   +1 more source

Cellular Profiles of Prodynorphin and Preproenkephalin mRNA-Expressing Neurons in the Anterior Olfactory Tubercle of Mice

open access: yesFrontiers in Neural Circuits, 2022
The olfactory tubercle (OT) is a striatal region that receives olfactory inputs. mRNAs of prodynorphin (Pdyn) and preproenkephalin (Penk), precursors of dynorphins and enkephalins, respectively, are strongly expressed in the striatum. Both produce opioid
Ayako Maegawa   +9 more
doaj   +1 more source

Opioid Receptors in Immune and Glial Cells-Implications for Pain Control [PDF]

open access: yes, 2020
Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Celik, Melih Ö., Machelska, Halina
core   +1 more source

The effect of ethanol consumption on the carboxypeptidase E activity on different age rats posterity

open access: yesИзвестия высших учебных заведений. Поволжский регион: Естественные науки, 2022
Background. The consumption of ethanol by dams strongly effects the offspring’s body, its health both at birth and throughout life. This effect has a particularly strong effect on the functioning of various regulatory systems, in particular ...
A.N. Vernigora, N.V. Volkova
doaj   +1 more source

Delta opioid receptors on nociceptive sensory neurons mediate peripheral endogenous analgesia in colitis

open access: yesJournal of Neuroinflammation, 2022
Background Inflammatory visceral pain is endogenously controlled by enkephalins locally released by mucosal CD4+ T lymphocytes in mice. The present study aimed at identifying opioid receptor(s) expressed on nociceptive sensory nerves involved in this ...
Xavier Mas-Orea   +5 more
doaj   +1 more source

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