Results 31 to 40 of about 1,391,378 (297)

Lack of μ-Opioid Receptor-Mediated G-Protein Activation in the Spinal Cord of Mice Lacking Exon 1 or Exons 2 and 3 of the MOR-1 Gene

Journal of Pharmacological Sciences, 2003
: The G-protein activation induced by μ-opioid receptor agonists was determined in spinal cord membranes from two types of μ-opioid receptor knockout mice: mice with a disruption of exon 1 (MOR (Exon 1)-KO) or exons 2 and 3 (MOR (Exons 2 and 3)-KO) of ...
Hirokazu Mizoguchi, Hsiang-En Wu, Minoru Narita, Ichiro Sora, F. Scott Hall, George R. Uhl, Horace H. Loh, Hiroshi Nagase, Leon F. Tseng   +8 more
doaj   +1 more source

Opioid Receptor-Mediated and Non-Opioid Receptor-Mediated Roles of Opioids in Tumour Growth and Metastasis

Frontiers in Oncology, 2021
Opioids are administered to cancer patients in the period surrounding tumour excision, and in the management of cancer-associated pain. The effects of opioids on tumour growth and metastasis, and their consequences on disease outcome, continue to be the ...
Claudia A. Scroope, Zane Singleton, Markus W. Hollmann, Marie-Odile Parat   +3 more
doaj   +1 more source

Update on opioid receptors

British Journal of Anaesthesia, 1994
82100
ATCHESON, R, LAMBERT, DG
openaire   +3 more sources

Usefulness for the combination of G protein- and β-arrestin-biased ligands of μ-opioid receptors: Prevention of antinociceptive tolerance

Molecular Pain, 2017
Background µ-Opioid receptor internalization is considered to be critically linked to antinociceptive tolerance. Although µ-opioid receptor agonists have been administered simultaneously with other drugs to control pain, little information is available ...
Tomohisa Mori, Naoko Kuzumaki, Takamichi Arima, Michiko Narita, Ryunosuke Tateishi, Takashige Kondo, Yusuke Hamada, Hirotsugu Kuwata, Miho Kawata, Mitsuaki Yamazaki, Kazuyuki Sugita, Akinobu Matsuzawa, Kanae Baba, Takayasu Yamauchi, Kimio Higashiyama, Miki Nonaka, Kanako Miyano, Yasuhito Uezono, Minoru Narita   +18 more
doaj   +1 more source

Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]

, 2013
There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Weingaertner, Inka Regine, Sarah Koutnik, Inka Regine Weingaertner, Koutnik, Sarah, Hermann Ammer, Ammer, Hermann   +5 more
core   +1 more source

Modeling buprenorphine reduction of fentanyl-induced respiratory depression

JCI Insight, 2022
BACKGROUND Potent synthetic opioids, such as fentanyl, are increasingly abused, resulting in unprecedented numbers of fatalities from respiratory depression.
Erik Olofsen, Marijke Hyke Algera, Laurence Moss, Robert L. Dobbins, Geert J. Groeneveld, Monique van Velzen, Marieke Niesters, Albert Dahan, Celine M. Laffont   +8 more
doaj   +1 more source

Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice

Haematologica, 2015
Treatment of pain with morphine and its congeners in sickle cell anemia is suboptimal, warranting the need for analgesics devoid of side effects, addiction and tolerance liability. Small-molecule nociceptin opioid receptor ligands show analgesic efficacy
Derek Vang, Jinny A. Paul, Julia Nguyen, Huy Tran, Lucile Vincent, Dennis Yasuda, Nurulain T. Zaveri, Kalpna Gupta   +7 more
doaj   +1 more source

Receptors for morphine and opioids

General Pharmacology: The Vascular System, 1976
Two points concerning enzymatic systems acting on disposal of morphine are discussed, namely the multiplicity of glucuronyltransferase and the effect of nalorphine on N-demethylation of morphine. Evidences of the presence of at least two different glucuronyltransferases in microsomes of rat liver, kidney and intestine are presented. These evidences are
Sánchez, Emílio, Tampier, Lutske, Mardones, Jorge   +2 more
openaire   +3 more sources

Characterization of methadone as a β-arrestin-biased μ-opioid receptor agonist

Molecular Pain, 2016
Background Methadone is a unique µ-opioid receptor agonist. Although several researchers have insisted that the pharmacological effects of methadone are mediated through the blockade of NMDA receptor, the underlying mechanism by which methadone exerts ...
Seira Doi BS, Tomohisa Mori PhD, Naoki Uzawa MS, Takamichi Arima BA, Tomoyuki Takahashi BA, Masashi Uchida BS, Ayaka Yawata BA, Michiko Narita BS, Yasuhito Uezono PhD, Tsutomu Suzuki PhD, Minoru Narita PhD   +10 more
doaj   +1 more source

The Potential of Methocinnamox as a Future Treatment for Opioid Use Disorder: A Narrative Review

Pharmacy, 2022
The opioid epidemic is an ongoing public health crisis, and the United States health system is overwhelmed with increasing numbers of opioid-related overdoses.
Colleen G. Jordan, Amy L. Kennalley, Alivia L. Roberts, Kaitlyn M. Nemes, Tenzing Dolma, Brian J. Piper   +5 more
doaj   +1 more source