Results 81 to 90 of about 2,577,172 (407)
Arthritis Care &Research, Accepted Article.Objectives This study aims to describe the frequency and timing of physician referrals to physical therapists (PT) and other treatments prescribed over 12 months in patients with recent onset of knee osteoarthritis (KOA). The study also aims to identify determinants of early PT referrals.
Samannaaz S. Khoja +4 more
wiley +1 more source
GRKs as Key Modulators of Opioid Receptor Function
Cells, 2020 Understanding the link between agonist-induced phosphorylation of the mu-opioid receptor (MOR) and the associated physiological effects is critical for the development of novel analgesic drugs and is particularly important for understanding the ...
Laura Lemel +2 more
doaj +1 more source
Arthritis Care &Research, Accepted Article.Objective Recent inflammatory bowel disease (IBD) treatment guidelines have recommended against NSAID use despite prevalent musculoskeletal symptoms and opioid overuse in this population. Given the discordance between changing national guidelines and potential clinical utility, we sought to assess national temporal trends in prescription NSAID and ...
Adam S. Mayer +5 more
wiley +1 more source
Palliative Care, 2010 Pain is one of the most common and incapacitating symptoms experienced by patients with advanced cancer. Methadone is a potent opioid with strong affinity for the µ opioid receptor. In addition to being a potent µ opioid receptor ligand, methadone blocks
Eric E. Prommer
doaj +2 more sources
Heteromerization Modulates mu Opioid Receptor Functional Properties in vivo
Frontiers in Pharmacology, 2018 Mu opioid receptors modulate a large number of physiological functions. They are in particular involved in the control of pain perception and reward properties.
Muzeyyen Ugur +2 more
doaj +1 more source
Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice. [PDF]
PLoS ONE, 2014 Neuropeptide FF (NPFF) is known to be an endogenous opioid-modulating peptide. Nevertheless, very few researches focused on the interaction between NPFF and endogenous opioid peptides. In the present study, we have investigated the effects of NPFF system
Zi-long Wang +10 more
doaj +1 more source
Frontiers in Oncology, 2022 BackgroundOpioid receptors are expressed not only by neural cells in the central nervous system, but also by many solid tumor cancer cells. Whether perioperative opioids given for analgesia after tumor resection surgery might inadvertently activate tumor
Amparo Belltall +16 more
doaj +1 more source
Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates [PDF]
, 2016 Fentanyl is a powerful opiate analgesic typically used for the treatment of severe and chronic pain, but its prescription is strongly limited by the well-documented side-effects.
Benyhe, Sa ́ndor +18 more
core +1 more source
Assessment of Pain Types in Recently Diagnosed Patients With Inflammatory Arthritis
Arthritis Care &Research, EarlyView.Objective Up to 40% of patients with inflammatory arthritis (IA) experience persistent pain, traditionally thought to be associated with a shift from peripherally to centrally mediated pain during the disease course in some patients. We assessed sensory profiles of recently diagnosed individuals with IA, hypothesizing that pain reported at this early ...
Zoe Rutter‐Locher +8 more
wiley +1 more source
Pharmacogenetics of analgesic drugs [PDF]
, 2013 • Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R +4 more
core +1 more source