Results 81 to 90 of about 2,542,870 (405)

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Methadone for Cancer Pain

Palliative Care, 2010
Pain is one of the most common and incapacitating symptoms experienced by patients with advanced cancer. Methadone is a potent opioid with strong affinity for the µ opioid receptor. In addition to being a potent µ opioid receptor ligand, methadone blocks
Eric E. Prommer
doaj   +2 more sources

Structural basis for bifunctional peptide recognition at human δ-Opioid receptor

Nature Structural &Molecular Biology, 2015
Bifunctional μ- and δ-opioid receptor (OR) ligands are potential therapeutic alternatives, with diminished side effects, to alkaloid opiate analgesics.
G. Fenalti, N. Zatsepin, Cecilia Betti, P. Giguère, G. Han, A. Ishchenko, Wei Liu, Karel Guillemyn, Haitao Zhang, Daniel James, Dingjie Wang, U. Weierstall, J. Spence, S. Boutet, M. Messerschmidt, Garth J. Williams, C. Gati, O. Yefanov, T. White, D. Oberthuer, M. Metz, C. Yoon, A. Barty, H. Chapman, S. Basu, J. Coe, C. Conrad, R. Fromme, P. Fromme, D. Tourwé, P. Schiller, B. Roth, S. Ballet, V. Katritch, R. Stevens, V. Cherezov   +35 more
semanticscholar   +1 more source

Weight Cycling Deregulates Eating Behavior in Mice via the Induction of Durable Gut Dysbiosis

Advanced Science, EarlyView.
Weight cycling in Humans is suspected to dysregulate eating behavior. Mice submitted to body weight cycling by alternating western‐type and regular chow diets display increased hedonic appetite when exposed to a palatable diet, reminiscent of binge‐eating episodes.
Mélanie Fouesnard, Adélie Salin, Sandy Ribes, Magali Monnoye, Gaëlle Champeil‐Potokar, Marie‐Sabelle Hjeij, Gwénaëlle Randuineau, Léa Le Gleau, Selma Ben Fradj, Catherine Philippe, Alexandre Benani, Isabelle Denis, Véronique Douard, Gaëlle Boudry   +13 more
wiley   +1 more source

Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy

Nature Communications, 2021
Mitragynine (MG) is an indole alkaloid from kratom plant that binds opioid receptors and as such presents a scaffold for the development of atypical opioid receptor modulators.
Srijita Bhowmik, Juraj Galeta, Václav Havel, Melissa Nelson, Abdelfattah Faouzi, Benjamin Bechand, Mike Ansonoff, Tomas Fiala, Amanda Hunkele, Andrew C. Kruegel, John. E. Pintar, Susruta Majumdar, Jonathan A. Javitch, Dalibor Sames   +13 more
doaj   +1 more source

An opioid-like system regulating feeding behavior in C. elegans [PDF]

, 2015
Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115
Artyukhin, Alexander B., Avery, Leon, Cheong, Mi Cheong, You, Yong-Jai   +3 more
core   +3 more sources

Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain

Advanced Science, EarlyView.
Ce‐UiO‐66‐Bupivacaine (CUB) demonstrates triple therapeutic innovation: 1) Sustained analgesia with ROS scavenging synergistically resolves neuropathic pain; 2) Microglia/astrocyte polarization switch reprograms the pro‐regenerative immune microenvironment; 3) CGRP‐TSP‐1 axis activation couples inflammation suppression to axon regeneration, defining a ...
Yue Wang, Xiuru Ji, Yu Sun, Han Wang, Ting Wang, Tao Luo, Yanyong Cheng, Jia Yan, Dalong Ni, Hong Jiang   +9 more
wiley   +1 more source

Modification of κ-Opioid Receptor Agonist-Induced Antinociception by Diabetes in the Mouse Brain and Spinal Cord

Journal of Pharmacological Sciences, 2005
The supraspinal and spinal antinociceptive effects of several κ-opioid receptor agonists were examined in diabetic and non-diabetic mice using the tail-flick assay. The antinociception induced by intrathecal (i.t.), but not intracerebroventricular (i.c.v.
Masahiro Ohsawa, Junzo Kamei
doaj  

M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes [PDF]

, 2017
Morphine inefficiency to induce the internalization of mu opioid (MOP) receptors observed in numerous experimental models constitutes a paradigm of G-protein coupled receptor (GPCR) functional selectivity.
Alvarez-Curto, Elisa, Lopez-Gimenez, Juan, Milligan, Graeme   +2 more
core   +1 more source

Perovskite‐Graphene Heterostructure Biosensor Integrated with Biotunable Nanoplasmonic Ternary Logic Gate for Ultrasensitive Cytokine Detection

Advanced Science, EarlyView.
This work proposes the first perovskite/graphene heterostructure‐based FET biosensor with uniquely biotunable ternary logic gating functionality for the detection of human IL6 cytokines. The biosensor integrates a lateral perovskite‐on‐graphene heterostructure phototransistor with a vertical bio‐nano‐photonic filter, achieving ultrahigh sensitivity ...
Jiaxing Sun, Lin Zhou, Zening Li, Guolin He, Hongju Mao, Jianlong Zhao, John A. Hunt, Xianfeng Chen   +7 more
wiley   +1 more source