Results 81 to 90 of about 2,911,994 (243)
Scientific Reports, 2022 Opioid agonists are powerful drugs for managing pain. However, their central side effects are limiting their use and drugs with similar potency, but a lower risk profile are needed. (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenylpropionamide (NFEPP)
Melih Ö. Celik +4 more
doaj +1 more source
Amniotic-Fluid Ingestion Enhances the Central\ud Analgesic Effect of Morphine [PDF]
, 1991 Amniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin ...
DiPirro, Jean M. +2 more
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Molecular Pain, 2013 Opioids are widely used as the pain reliever and also notorious for being addictive drugs. Sex differences in the opioid analgesia and addiction have been reported and investigated in human subjects and animal models.
Cynthia Wei-Sheng Lee, Ing-Kang Ho
semanticscholar +1 more source
Endogenous opioid peptides in the descending pain modulatory circuit.
Neuropharmacology, 2020 The opioid epidemic has led to a serious examination of the use of opioids for the treatment of pain. Opioid drugs are effective due to the expression of opioid receptors throughout the body. These receptors respond to endogenous opioid peptides that are
Elena E Bagley, S. Ingram
semanticscholar +1 more source
PLoS ONE, 2013 Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression.
Raphaël Weibel +9 more
semanticscholar +1 more source
Opioid system is necessary but not sufficient for antidepressive actions of ketamine in rodents
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Ketamine, an NMDA receptor antagonist, has generated intense excitement as a therapy for treatment-resistant depression. However, ketamine and its metabolites can act on a wide range of targets, including opioid receptors, which has raised ...
Matthew E. Klein +3 more
semanticscholar +1 more source
The Hippocampus Is the Place to Be: Opioid Receptors and LTP
Cell Reports, 2019 Nam et al. (2019) genetically modulate the expression of astrocytic μ-opioid receptors to reveal they are necessary for drug-induced conditioned place preference.
Thomas M. Sanderson +3 more
doaj +1 more source
Caenorhabditis elegans as a model system to identify therapeutics for alcohol use disorders [PDF]
, 2019 Alcohol use disorders (AUDs) cause serious problems in society and few effective treatments are available. Caenorhabditis elegans (C. elegans) is an excellent invertebrate model to study the neurobiological basis of human behavior with a conserved, fully
Bell, Richard L. +6 more
core +1 more source
Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions
Molecular Pharmacology, 2020 In the mid-1970s, an intense race to identify endogenous substances that activated the same receptors as opiates resulted in the identification of the first endogenous opioid peptides.
L. Fricker +3 more
semanticscholar +1 more source
Behavioral and pharmacological characterization of a mouse model of palatable diet alternation [PDF]
, 2017 Obesity and eating disorders represent a severe problem in Western societies. Both the increased availability of highly palatable foods and dieting are major risk factors contributing to the epidemic disorders of feeding. The purpose of this study was to
Schlain, Gabrielle Star
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