Results 61 to 70 of about 75,591 (303)

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Mind the gap: a quality improvement study to determine health care value of rapid-access telemedicine addiction treatment in recently incarcerated individuals

BMC Health Services Research
Background Previously incarcerated individuals experience a significant and vulnerable time post-release, highlighted by a greater than 129 times higher risk of overdose death.
John Golden, Divya Venkat, Yue Yin, Thomas Robertson   +3 more
doaj   +1 more source

Perceived social support and clinical characteristics in males with opioid use disorder on maintenance therapy

, 2022
Perceived social support (PSS) is an important factor affecting the treatment outcomes in substance use disorders. The aim of this study was to determine the level of PSS among males with opioid use disorder receiving treatment. Method: The population of
Gıynaş Ayhan, Medine
core   +1 more source

Immunopharmacotherapies for Treating Opioid Use Disorder [PDF]

Trends in Pharmacological Sciences, 2018
The current opioid crisis has reinvigorated interest in the development of therapeutics for opioid use disorder (OUD), and the choice of preclinical translational endpoints is an essential consideration. Antiopioid immunopharmacotherapies (e.g., conjugate vaccines) that sequester drug peripherally, preventing opioids from reaching targeted receptors in
Matthew L. Banks, Margaret E. Olson, Kim D. Janda   +2 more
openaire   +2 more sources

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Effect of police action on low-barrier substance use disorder service utilization

Harm Reduction Journal, 2022
Background Police action can increase risky substance use patterns by people who use drugs (PWUD), but it is not known how increased police presence affects utilization of low-barrier substance use disorder bridge clinics.
Karrin Weisenthal, Simeon D. Kimmel, Jessica Kehoe, Marc R. Larochelle, Alexander Y. Walley, Jessica L. Taylor   +5 more
doaj   +1 more source

Association of opioid use disorder with healthcare utilization and cost in a public health system.

, 2022
AIM: To quantify the healthcare costs associated with opioid use disorder among members in a public healthcare system and compare them with healthcare costs in the general population. DESIGN: Retrospective cohort study.
Kor, Ariel, Barda, Noam, Lev-Ran, Shaul, Miron, Oren, Lev‐Ran, Shaul, Balicer, Ran   +5 more
core   +1 more source

Pharmacogenetics of Opioid Use Disorder Treatment [PDF]

CNS Drugs, 2018
Opioid use disorder (OUD) is a significant health problem in the United States and many other countries. A combination of issues, most notably increased prescription of opioid analgesics, has resulted in climbing rates of opioid abuse and overdose over the last decade.
Richard C. Crist, Toni-Kim Clarke, Wade H. Berrettini   +2 more
openaire   +2 more sources

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Perinatal healthcare experiences of pregnant and parenting people with a history of substance use disorder: a qualitative study

BMC Pregnancy and Childbirth
Background Clinical guidelines in the United States (U.S.) recommend a patient-centered approach to healthcare for pregnant people with substance use disorders (SUD); however, pregnant people with SUD often describe experiencing stigmatization and shame ...
Carol Y. Franco-Rowe, Angela E. Lee-Winn, Venice Ng Williams, Connie Lopez, Gregory J. Tung, Mandy A. Allison   +5 more
doaj   +1 more source