Results 71 to 80 of about 15,507,011 (297)

Opioid mediated activity and expression of mu and delta opioid receptors in isolated human term non-laboring myometrium [PDF]

, 2013
The existence of opioid receptors in mammalian myometrial tissue is now widely accepted. Previously enkephalin degrading enzymes have been shown to be elevated in pregnant rat uterus and a met-enkephalin analogue has been shown to alter spontaneous ...
McMorrow, Jason P., Carey, Michael F., Campion, Deirdre P., O\u27Connor, J. J., Fanning, Rebecca A., O'Connor, J. J.   +5 more
core   +1 more source

Therapeutic Prospects of Ketamine for Cataplexy in Narcolepsy Type 1: Evidence from a Human Case and a Murine Model

Annals of Neurology, EarlyView.
Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau, Sebastien Arthaud, Leila Langbour, Silvia Melzi, Aurelie Richard‐Mornas, Hannah Doudoux, Benjamin Rolland, Laure Peter‐Derex, Christelle Peyron   +8 more
wiley   +1 more source

Multimodal acute pain management in the parturient with opioid use disorder: a review.

The opioid epidemic in the United States has led to an increasing number of pregnant patients with opioid use disorder (OUD) presenting to obstetric units.
Ayoub, Mohamad Ibrahim, Mrad, Ismat, Koltenyuk, Victor, Kumaraswami, Sangeeta, Choe, Ian, Xu, Jeff L   +5 more
core   +2 more sources

Best practices across the continuum of care for the treatment of opioid use disorder. [PDF]

, 2018
People living with an opioid use disorder in Canada should have access to comprehensive treatment options that meet all their needs. Best Practices across the Continuum of Care for the Treatment of Opioid Use Disorder presents services that should be ...
Taha, Sheena
core  

Health Extension Agents: An Approach to Addressing Opioid Use Disorder in Rural Communities [PDF]

This is a research brief describing what Health Extension agents are, why they're useful, and what role they can play in addressing opioid use disorder in rural ...
Northwest Rural Opioid Technical Assistance Collaborative
core   +1 more source

Pharmacogenetics of Opioid Use Disorder Treatment [PDF]

CNS Drugs, 2018
Opioid use disorder (OUD) is a significant health problem in the United States and many other countries. A combination of issues, most notably increased prescription of opioid analgesics, has resulted in climbing rates of opioid abuse and overdose over the last decade.
Richard C. Crist, Toni-Kim Clarke, Wade H. Berrettini   +2 more
openaire   +2 more sources

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Incarceration history and opioid use among adults living with HIV and chronic pain: a secondary analysis of a prospective cohort study

Health & Justice
Background Adults living with HIV have disproportionately high chronic pain, prescription opioid use, history of substance use, and incarceration. While incarceration can have long-lasting health impacts, prior studies have not examined whether distant (>
Anna B. Lichtiger, Yuting Deng, Chenshu Zhang, Justina Groeger, Hector R. Perez, Gayatri Nangia, Melanie Prinz, Emma Richard, Matthew Glenn, Ana Alicia De La Cruz, Ariana Pazmino, Chinazo O. Cunningham, K Rivet Amico, Aaron Fox, Joanna L. Starrels   +14 more
doaj   +1 more source

Editorial: Opioids and opioid-use disorders

Frontiers in Pharmacology, 2023
Giordano de Guglielmo, Marsida Kallupi, Andrea Cippitelli, Daniele Caprioli, Daniele Caprioli, Kabirullah Lutfy   +5 more
openaire   +4 more sources

Proto‐Panic Modulation by Caffeine‐Proteinoid Complexes

Journal of Applied Polymer Science, EarlyView.
Caffeine–proteinoid microspheres synthesized by thermal polymerization exhibit compartmentalized drug loading with encapsulation efficiencies of 61%–82% and triphasic release kinetics. Electrochemical monitoring reveals multi‐scale oscillatory dynamics consistent with chaotic and damped harmonic behavior, while Boolean logic operations demonstrate ...
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source