Results 71 to 80 of about 75,991 (302)

Immunopharmacotherapies for Treating Opioid Use Disorder [PDF]

Trends in Pharmacological Sciences, 2018
The current opioid crisis has reinvigorated interest in the development of therapeutics for opioid use disorder (OUD), and the choice of preclinical translational endpoints is an essential consideration. Antiopioid immunopharmacotherapies (e.g., conjugate vaccines) that sequester drug peripherally, preventing opioids from reaching targeted receptors in
Matthew L. Banks, Margaret E. Olson, Kim D. Janda   +2 more
openaire   +2 more sources

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Pain in the management of opioid use disorder [PDF]

, 2016
Sunil Sirohi,1 Amit K Tiwari21Laboratory of Endocrine and Neuropsychiatric Disorders, Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, 2Department of Pharmacology and Experimental ...
Sirohi S, Tiwari AK
core  

Examining access to primary care for people with opioid use disorder in Ontario, Canada: a randomized clinical trial. [PDF]

, 2022
Importance: People with opioid use disorder are less likely than others to have a primary care physician. Question: Are family physicians less likely to accept people with opioid use disorder as new patients than people with diabetes?
Mogic, Lana, Moineddin, Rahim, Meaney, Christopher, Kiran, Tara, Spithoff, Sheryl, Hum, Susan   +5 more
core   +1 more source

Effect of police action on low-barrier substance use disorder service utilization

Harm Reduction Journal, 2022
Background Police action can increase risky substance use patterns by people who use drugs (PWUD), but it is not known how increased police presence affects utilization of low-barrier substance use disorder bridge clinics.
Karrin Weisenthal, Simeon D. Kimmel, Jessica Kehoe, Marc R. Larochelle, Alexander Y. Walley, Jessica L. Taylor   +5 more
doaj   +1 more source

Pharmacogenetics of Opioid Use Disorder Treatment [PDF]

CNS Drugs, 2018
Opioid use disorder (OUD) is a significant health problem in the United States and many other countries. A combination of issues, most notably increased prescription of opioid analgesics, has resulted in climbing rates of opioid abuse and overdose over the last decade.
Richard C. Crist, Toni-Kim Clarke, Wade H. Berrettini   +2 more
openaire   +2 more sources

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Perinatal healthcare experiences of pregnant and parenting people with a history of substance use disorder: a qualitative study

BMC Pregnancy and Childbirth
Background Clinical guidelines in the United States (U.S.) recommend a patient-centered approach to healthcare for pregnant people with substance use disorders (SUD); however, pregnant people with SUD often describe experiencing stigmatization and shame ...
Carol Y. Franco-Rowe, Angela E. Lee-Winn, Venice Ng Williams, Connie Lopez, Gregory J. Tung, Mandy A. Allison   +5 more
doaj   +1 more source

Nontobacco Nicotine Dependence Is Associated With Perioperative Complications and Repeat Surgery After Arthroscopic Rotator Cuff Repair

Arthroscopy, EarlyView.
Purpose To compare perioperative complications and revision surgery rates between following primary rotator cuff repair among patients with nontobacco nicotine dependence (NTND), no nicotine dependence, and traditional tobacco‐related nicotine dependence.
Samuel A. Florentino, Alexander N. Berk, Logan M. Good, Jeremy M. Adelstein, Robert J. Wetzel, George Ochenjele, Joshua K. Napora   +6 more
wiley   +1 more source

Health Extension Agents: An Approach to Addressing Opioid Use Disorder in Rural Communities [PDF]

This is a research brief describing what Health Extension agents are, why they're useful, and what role they can play in addressing opioid use disorder in rural ...
Northwest Rural Opioid Technical Assistance Collaborative
core   +2 more sources