Results 51 to 60 of about 16,198,215 (212)

Multimodal acute pain management in the parturient with opioid use disorder: a review.

The opioid epidemic in the United States has led to an increasing number of pregnant patients with opioid use disorder (OUD) presenting to obstetric units.
Ayoub, Mohamad Ibrahim, Mrad, Ismat, Koltenyuk, Victor, Kumaraswami, Sangeeta, Choe, Ian, Xu, Jeff L   +5 more
core   +2 more sources

Predicting opioid use disorder before and after the opioid prescribing peak in the United States: A machine learning tool using electronic healthcare records

Health Informatics Journal, 2023
Existing predictive models of opioid use disorder (OUD) may change as the rate of opioid prescribing decreases. Using Veterans Administration’s EHR data, we developed machine-learning predictive models of new OUD diagnoses and ranked the importance of ...
Tyler J Banks, Tung D Nguyen, Jeffery K Uhlmann, Satish S Nair, Jeffrey F Scherrer   +4 more
doaj   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Treatment interventions for co-occurring opioid use disorder, and sleep disturbances: a scoping review

Substance Abuse Treatment, Prevention, and Policy
Background Opioid use disorder (OUD) is part of the broader spectrum of substance use disorders often complicated by psychiatric symptoms such as depression, anxiety, PTSD (Post-Traumatic Stress Disorder), and sleep disturbances, with insomnia being ...
Elisabeth Ruppert, Julie Rolling, Alessandro Medde, Amaury Durpoix, Laurence Lalanne   +4 more
doaj   +1 more source

New opioid use and risk of opioid-related adverse events among adults with intellectual and developmental disabilities in Ontario, Canada

BJPsych Open, 2022
Background Individuals with intellectual and developmental disability (IDD) can have a high prevalence of pain, which can be managed with prescription opioids.
Qi Guan, Siyu Men, Yona Lunsky, David N. Juurlink, Susan E. Bronskill, Hannah Wunsch, Tara Gomes   +6 more
doaj   +1 more source

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

Addiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper, Francesca Small, Sam Brown, Michael Kelleher, Luke Mitcheson, James Rucker, Allan H. Young, John Marsden   +7 more
wiley   +1 more source

5‐Methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden, Michael Kelleher, Fiona Dunbar, Anna O. Ermakova, Luke Mitcheson, Claire Roberts, James J. Rucker, Gemma Scott, Ivan Saeger, Francesca Small, Mathieu Seynaeve   +10 more
wiley   +1 more source

Retrospectively assessed subjective effects of initial opioid use differ between opioid misusers with opioid use disorder (OUD) and those who never progressed to OUD: Data from a pilot and a replication sample

Journal of Neuroscience Research, 2020
Abstract Attempts to identify opioid users with increased risk of escalating to opioid use disorder (OUD) have had limited success. Retrospectively assessed subjective effects of initial opioid misuse were compared in a pilot sample of opioid misusers (nonmedical use ≤60 times lifetime) who had never met criteria ...
Arpana Agrawal, Paul W. Jeffries, A. Benjamin Srivastava, Vivia V. McCutcheon, Michael T. Lynskey, Andrew C. Heath, Elliot C. Nelson   +6 more
openaire   +4 more sources

Risks and mitigations of substance use disorders with dental procedures-related opioid prescriptions: A systematic review

Drug and Alcohol Dependence Reports
Dental opioid prescriptions remain one of the most common initial exposures to opioids worldwide. Although opioid prescribing in dentistry has declined, even limited exposure to opioids may be a significant risk factor for developing Opioid Use Disorder (
Ruben Mikaelyan, Alex Alvarado, Carol Kunzel, Sean X. Luo   +3 more
doaj   +1 more source

Prescribed alternative stimulants among people who use unregulated stimulants: Examining the association between maximum dose reached and medication discontinuation in the first 3 years of implementation in British Columbia, Canada

Addiction, EarlyView.
Abstract Background and aims In 2020, British Columbia (BC), Canada, introduced ‘Prescribed Alternatives’ (PA) as an approach to offering regulated substances to people accessing the unregulated supply. This study aimed to estimate and compare prescribing characteristics of dextroamphetamine and methylphenidate stimulant PAs in BC, to estimate ...
Bin Zhao, Kevin Hu, Roshni Desai, Shania Au, Kali‐olt Sedgemore, Vitor Tardelli, Addie Carter, Paxton Bach, Christian Schutz, Amanda Slaunwhite, Alexis Crabtree, Heather Palis   +11 more
wiley   +1 more source