Results 231 to 240 of about 38,044 (266)

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, Volume 13, Issue 55, 5 October 2026.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

Integrated plasma and duodenal content metabolomics reveals metabolic mechanisms underlying residual feed intake differences in broilers. [PDF]

Poult Sci
Jiang T, Wang Z, Yang Z, Yuan H, Luo J, Liu Y, Fu Q, Li X, Tan C, Yang X.   +9 more
europepmc   +1 more source

Serum Bile Acid Metabolomics‐Based Machine Learning Model for Non‐Invasive Diagnosis of Gastric Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Gastric cancer (GC) has posed a severe threat to human health. Metabolomics analysis has been applied in the context of multiple diseases, offering new perspectives for the development of non‐invasive detections. Objective We aimed to develop a diagnostic model for GC based on a serum bile acid (BA) panel.
Nuo Yao, Xiaodong Qu, Ya Zheng, Songbo Li, Xidong Fang, Kexin Lin, Xingyu Zhao, Danyang Zhao, Yongning Zhou, Junye Liu, Yongquan Shi   +10 more
wiley   +1 more source

Metabolomic Profiling Delineates Stage-Associated Metabolic Remodelling in Cardiovascular-Kidney-Metabolic Syndrome. [PDF]

Diabetes Metab Res Rev
Gong X, Li C, Chen J, Wang Y, Tang W, Zhang X, Yin J, Zhao X, Yu H, Fu P, Zeng X.   +10 more
europepmc   +1 more source

Hyperglycemia‐Induced Microglial CTSS Disrupts Blood‐Retinal Barrier Integrity via PAR2‐Dependent Downregulation of Endothelial MFSD2A

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Hyperglycemia induces retinal microglial activation and CTSS upregulation, disrupting microglia‐endothelial crosstalk via PAR2‐dependent MFSD2A suppression. Abnormal activation of microglia amplifies retinal inflammatory cascade, enhances transcytosis, compromises BRB integrity, and accelerates DR progression.
Chengye Xu, Hongxue Li, Qian Xu, Kangqi Zhao, Yangwen Chen, Yan Wang, Wei Zou, Binglin Kuang, Hongyu Kuang   +8 more
wiley   +1 more source

Comparative metabolomic analysis of antler-derived medicinal materials from red deer and sika deer. [PDF]

Sci Rep
Yu Z, Hu Z, Yang X, Huang Y, Jiang D, Ding Z, Liang L, Shu Y, Jiang Y.   +8 more
europepmc   +1 more source

Metabolomics Analysis Revealed That SXZ Ameliorates Cognitive Impairment in Naturally Aged Rats by Promoting Glutathione Metabolism and Inhibiting the Ferroptosis Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In aged rats, 6‐month SXZ treatment reversed spatial memory deficits and preserved hippocampal integrity. Mechanistic assays show that SXZ promotes glutathione metabolism and inhibits ferroptosis via p53/SLC7A11/GPX4 and Keap1/Nrf2/HO‐1 pathways. SXZ is a novel neuroprotective agent against age‐related cognitive decline.
Mengya Liu, Shunyi Li, Yonglin Liang, Yugui Zhang, Xutong Jia, Yongqiang Duan, Min Bai   +6 more
wiley   +1 more source

Dietary <i>Bacillus coagulans</i> supplementation improves liver health and modulates hepatic metabolic profiles in juvenile fourfinger threadfin (<i>Eleutheronema tetradactylum</i>). [PDF]

Front Microbiol
Li J, Chen N, Zheng AN, He SP, Liu WB, Lu JH, Jin MX, Wang LJ, Zhang HJ, Mkulo EM, Tang BG, Zhou H, Wang B, Huang JS, Wang ZL.   +14 more
europepmc   +1 more source

Computational strategies to address therapeutic resistance in estrogen receptor‐positive breast cancer: A narrative review of molecular docking, molecular dynamics simulations, and emerging therapeutic targets

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Computational drug discovery integrates molecular docking, molecular dynamics simulations, and translational clinical targeting to identify next‐generation therapeutics that overcome endocrine resistance in ER‐positive breast cancer. Combined with multi‐omics, artificial intelligence, and biomarker‐guided precision oncology, these approaches accelerate
Emmanuel Ifeanyi Obeagu, Yaregal Asres
wiley   +1 more source

Metabolomic Approaches in Fermented Meat Products: Focus on Lactic Acid Bacteria and Starter Cultures. [PDF]

Microorganisms
Sidira M, Nelios G, Varzakas T.
europepmc   +1 more source