Results 61 to 70 of about 816 (174)

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

Magnetoencephalography for the investigation and diagnosis of Mild Traumatic Brain Injury [PDF]

, 2022
Mild Traumatic Brain Injury (mTBI), (or concussion), is the most common type of brain injury. Despite this, it often goes undiagnosed and can cause long term disability—most likely caused by the disruption of axonal connections in the brain.
Rier, Lukas
core   +3 more sources

From simulation to clinic: Assessing the required channel count for effective clinical use of OPM-MEG systems

NeuroImage
The channel count in an Optically Pumped Magnetometer Magnetoencephalography (OPM-MEG) system plays a pivotal role in determining its overall performance.
Bing Yan, Yuming Peng, Yixiang Zhang, Yun Zhang, Haonan Zhang, Yifu Cao, Chang Sun, Ming Ding   +7 more
doaj   +1 more source

Multimodal neuroimaging with optically pumped magnetometers: A simultaneous MEG-EEG-fNIRS acquisition system

NeuroImage, 2022
Multimodal neuroimaging plays an important role in neuroscience research. Integrated noninvasive neuroimaging modalities, such as magnetoencephalography (MEG), electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS), allow neural ...
Xingyu Ru, Kaiyan He, Bingjiang Lyu, Dongxu Li, Wei Xu, Wenyu Gu, Xiao Ma, Jiayi Liu, Congcong Li, Tingyue Li, Fufu Zheng, Xiaozhou Yan, Yugang Yin, Hongfeng Duan, Shuai Na, Shuangai Wan, Jie Qin, Jingwei Sheng, Jia-Hong Gao   +18 more
doaj   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Assessing the Relative Importance of Imaging and Serum Biomarkers in Capturing Disability, Cognitive Impairment, and Clinical Progression in Multiple Sclerosis

Advanced Science, EarlyView.
Using machine‐learning analyses in two independent multiple sclerosis cohorts, spinal cord atrophy and cortical degeneration emerged as key predictors of disability and progression independent of relapses. Deep gray matter damage further improved prediction, while serum biomarkers of brain damage provided complementary information, highlighting the ...
Alessandro Cagol, Pascal Benkert, Sabine Schaedelin, Mario Ocampo‐Pineda, Noemi Montobbio, Po‐Jui Lu, Batuhan Ayci, Antonia Wenger, Alfi Aran Shukur, Kornelius Kaim, Lester Melie‐Garcia, Matthias Weigel, Alessio Signori, Pasquale Calabrese, Ludwig Kappos, Maria Pia Sormani, Jens Kuhle, Cristina Granziera   +17 more
wiley   +1 more source

Wireless optically pumped magnetometer MEG

NeuroImage
The current magnetoencephalography (MEG) systems, which rely on cables for control and signal transmission, do not fully realize the potential of wearable optically pumped magnetometers (OPM). This study presents a significant advancement in wireless OPM-
Hao Cheng, Kaiyan He, Congcong Li, Xiao Ma, Fufu Zheng, Wei Xu, Pan Liao, Rui Yang, Dongxu Li, Lang Qin, Shuai Na, Bingjiang Lyu, Jia-Hong Gao   +12 more
doaj   +1 more source

Structural Basis of the Membrane Association by the Conserved RocS Membrane‐Targeting Sequence in Streptococcus

Advanced Science, EarlyView.
Chromosome segregation in Streptococcus pneumoniae depends on RocS, a bitopic protein whose membrane‐anchoring mechanisms were unclear. Using NMR and AFM, this study reveals that the widely conserved RocS anchor binds to membranes via a conserved kink‐helix motif which inserts into lipid nanodomains.
Ana Álvarez‐Mena, Estelle Morvan, Clara Lambert, Anagha Kallisseri Parambil, Martin Lefeuvre, Zeren Xu, Nadia El Mammeri, Florian Malard, Erick J. Dufourc, Cécile Feuillie, Christophe Grangeasse, Birgit Habenstein   +11 more
wiley   +1 more source

A first-in-human application of OPM-MEG for localizing motor activity area: Compared to functional MRI

NeuroImage
Background: Accurately localizing brain motor areas is vital for protecting motor function during neurosurgical procedures. Magnetoencephalography (MEG) based on optically pumped magnetometer (OPM) improves the availability of MEG in clinical ...
Tai Sun, Xiaohan Chi, Yuming Peng, Qianhe Zhang, Kang Liu, Yiwen Ma, Ming Ding, Nan Ji, Yang Zhang   +8 more
doaj   +1 more source

Test-retest reliability of auditory MMN measured with OPM-MEG

AbstractIn this paper, we report results from an investigation of auditory mismatch responses as measured by magnetoencephalography (MEG) based on optically pumped magnetometers (OPM). Specifically, as part of a quality control study, we examined the reliability and validity of auditory mismatch negativity (MMN) recordings, obtained with a newly ...
Demko L, Iglesias S, Mellor S, Brand K, Kalberer A, Köchli L, Marino S, Zimmermann N, Heinzle J, Stephan KE.   +9 more
europepmc   +2 more sources