Results 71 to 80 of about 1,076,583 (288)

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

Improvements in Blood Pressure Control and the Hypertension Care Continuum Over 2 Years in Urban Haiti Amidst Civil Unrest

The Journal of Clinical Hypertension
Hypertension (HTN) is the leading cause of death worldwide, yet only 8% of individuals have controlled blood pressure (BP) in low‐ and middle‐income countries, with particular challenges in humanitarian crisis settings including Haiti.
Miranda Metz, Rodney Sufra, Anju Ogyu, Vanessa Rouzier, Reichling St. Sauveur, Kelly Celestin, Guyrlaine Forrestal, Fabyola Preval, Mirline Jean, Suzanne Edwidge Marcelin, Auguste Sarine, Catherine Bennett, Serena Koenig, Kenneth Jamerson, Jean William Pape, Lily D. Yan, Margaret L. McNairy   +16 more
doaj   +1 more source

Does Contract Farming Reduce Pesticide Use? Panel Data Evidence From Smallholder Farmers in China

Agribusiness, EarlyView.
ABSTRACT The inappropriate and excessive use of pesticides poses a major threat to human and ecosystem health in the agri‐food sector. While existing studies have examined the potential of contract farming to address this issue, most have focused on large‐scale farms and relied on small or transactional datasets, often leaving the role of crop‐specific
Zhihui Liang, Shan Jin, Matthew Gorton
wiley   +1 more source

Reproductive health characteristics among women living in severe poverty in urban Haiti

Reproductive Health
Background Data on women’s reproductive health in settings facing extreme poverty are limited. We describe the reproductive health characteristics across the life course of women living in urban Port-au-Prince, Haiti, and identify factors associated with
Wheytnie Alexandre, Anju Ogyu, Rodney Sufra, Lily D. Yan, Marie M. Deschamps, Catherine Bennett, Jean William Pape, Laura C. Alonso, Vanessa Rouzier, Margaret L. McNairy   +9 more
doaj   +1 more source

Lymphopenia during opportunistic infections.

, 2016
Lymphopenia during opportunistic infections.
Marius Vögelin (2805241), Michael Fried (139963), Jonas Zeitz (389786), Pascal Frei (139961), Michael Scharl (139957), Gerhard Rogler (139954), Sylvie Scharl (2805235), Stephan R. Vavricka (139972), Michael C. Sulz (2805238), Luc Biedermann (139959)   +9 more
core   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Antimicrobial therapy for the treatment of opportunistic infections in HIV/AIDS patients: a critical appraisal

, 2011
Jo Seddon1, Sanjay Bhagani21Department of Infectious Diseases, Imperial College Healthcare NHS Trust, London, UK; 2Department of Infection and Immunity, Royal Free Hospital NHS Trust, London, UKAbstract: The widespread use of antiretroviral therapy (ART)
Seddon J, Bhagani S
core  

Longitudinal Modulation of the Gut Microbiome and Growth Performance by Phytochemicals as Antibiotic Alternatives in Swine Production

Animal Research and One Health, EarlyView.
We conducted a longitudinal trial across nursery, growing, and finishing phases, showing that phytochemical supplementation as a potential antibiotic alternative reduced potential pathogens and promoted beneficial Lactobacillus amylovorus in the nursery phase, and enriched amino acid and carbohydrate metabolism pathways (prediction) during finishing ...
Ziyu Liu, Samantha Howe, Yang Tian, Alisun N. Watson, Jason E. Farrar, Christopher E. Randolph, Jaime Andrés Ángel Isaza, Álvaro José Uribe, Yan Huang, Michael Looper, Jiangchao Zhao, Tsungcheng Tsai   +11 more
wiley   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source