Phytotherapy Research, EarlyView.ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong +7 more
wiley +1 more source
Genomic characterization of <i>Pseudomonas aeruginosa</i> from canine otitis highlights the need for a One Health approach to this opportunistic pathogen. [PDF]
Microb GenomNewstead L +5 more
europepmc +1 more source
Infection risk in rheumatoid arthritis patients treated with biologic and targeted therapies
Rheumatology &Autoimmunity, EarlyView.In this context, infections associated with each biologic and targeted drug are summarized to inform the stratification of RA patients, including the characteristics of the susceptible patients and their concomitant therapy. We aim to provide a benefit‐risk analysis for clinical decision, and vital indications for the prevention of highly correlated ...
Lujing Wang, Jieshi Lin, Jie Qian
wiley +1 more source
<i>Enterococcus lactis</i> is ecologically and genetically distinct from the major opportunistic pathogen <i>Enterococcus faecium</i>. [PDF]
Microb GenomRoss TA +8 more
europepmc +1 more source
Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy
VIEW, EarlyView.This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley +1 more source
VIEW, EarlyView.Comprehensive evaluation of metagenomic next‐generation sequencing for pathogen identification in patients with suspected infection: Establishment of a standardized validation workflow. Abstract Metagenomic next‐generation sequencing (mNGS) enables unbiased identification of pathogens directly from clinical specimens. Despite its growing application in
Wen Shu +11 more
wiley +1 more source
Untangling the Effects of Hydraulic Design on Opportunistic Pathogen Growth Potential with an at-Scale Plumbing Rig. [PDF]
ACS ES T WaterBusch S +4 more
europepmc +1 more source
Ontogeny of foraging behaviour in an opportunistic gull inhabiting urban marine ecosystems
Wildlife Biology, EarlyView.Urbanization affects ecosystems by reducing biodiversity and displacing species from native habitats. While some suffer, others, like urban wildlife, adapt through innovative feeding and behaviours that improve their fitness in human‐altered settings. Despite research on wildlife in urban areas, the development of foraging behaviour in urban species is
Joan Navarro +7 more
wiley +1 more source
A novel type of hemoglobin confers host-derived nitric oxide resistance to the opportunistic pathogen Acinetobacter baumannii. [PDF]
Sci RepBeas JZ +4 more
europepmc +1 more source
Wildlife Biology, EarlyView.The expansion of the golden jackal Canis aureus in Europe, caused mainly by habitat fragmentation, climate change and the decline of large carnivores until half a century ago, poses emerging challenges for newly colonised regions. With the arrival of a new species, potential effects on local animal communities, hunting, livestock husbandry or the ...
Pablo del Rio +3 more
wiley +1 more source