Results 91 to 100 of about 1,581,190 (302)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Relationships between Opposition and Powers in Tajikistan:History and Present Time
Проблемы постсоветского пространства, 2017 After becoming independent the relationships between the official powers of Tajikistan and oppo- sition were shaping not easily. The opposition was, in fact, estranged from development and implementation of internal and foreign policy.
H. H. Khurramov
doaj
The Iranian Kurdistan Democratic Party 1963-1979 AD
آداب الكوفة, 2012 The Iranian Kurdistan Democratic Party is considered one of the nationalist parties that the Iranian political scene witnessed, starting from the year of its founding in 1945 until the banning of political parties in 1979 AD, with the victory of the ...
Ali Muhammad, Ahmed Alalaq
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Études Écossaises, 2013 Many aspects of the canonical mythology surrounding the wave of migration from the Highlands between 1801 and 1803 have been reassessed by historians.
Alice Lemer-Fleury
doaj +1 more source
Which Reputations Does a Brand Owner Need? Evidence from Trade Mark Opposition [PDF]
At least two: the reputation of their brand and a reputation for being tough on imitators of this brand. Sustaining a brand requires both investment in its reputation amongst consumers and the defence of the brand against followers that infringe upon it.
Graevenitz, Georg von
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
ILCEA, 2013 The article deals with the contemporary interpretations of the Great Reform of 1861. The article demonstrates that the Great Reform has occupied a significant place in the political rhetoric and discourse of recent political and social powers. There is a
Sergueï Kondratiev
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Patterns of Force: System Strength, Terrorism and Civil War [PDF]
We jointly analyze the genesis of terrorism and civil war, providing a simple conceptual framework to explain why violent opposition groups choose distinct forms of violence (i.e., terrorism and open rebellion).
Andreas Freytag +3 more
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