Results 91 to 100 of about 280,340 (213)
Can Post-Grant Reviews Improve Patent System Design? A Twin Study of US and European Patents [PDF]
, 2006 This paper assesses the impact of adopting a post-grant review institution in the US patent system by comparing the “opposition careers” of European Patent Office (EPO) equivalents of litigated US patents to those of a control group of EPO patents.
Harhoff, Dietmar, Graham, Stuart J.H.
core +1 more source
L’opposition au cœur de l’analyse des sports collectifs
eJournal de la Recherche sur l'Intervention en Éducation Physique et Sport, 2019 In team sports, the primary rules of the game are based on the logic of the game itself. The main characteristic is the systematic opposition relationship between attack and defense.
Eric Duprat
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Prospects for Improving U.S. Patent Quality via Post-grant Opposition [PDF]
The recent surge in U.S. patenting and expansion of patentable subject matter has increased patent office backlogs and raised concerns that in some cases patents of insufficient quality or with inadequate search of prior art are being issued. At the same
Bronwyn H. Hall +2 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
“Silence – A Fable” di Edgar Allan Poe
RSA Journal, 1990 There is no doubt that Poe's writing bears the traces of an excessive compulsion for repetition. The essay analyses "Silence," a short 'fable' written in 1833-35, in which the over-recurrence of repetition mirrors pain, anxiety, awe, and death by ...
Paola Zaccaria
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2014 The aim of the seminar is to explore opposition movements from the Italian city-states of the 16th century to the absolute monarchies of the 18th century, also with attention to developments in England and the Dutch Republic.
ARIENZO, ALESSANDRO
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source