Results 111 to 120 of about 1,581,190 (302)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A Turbulent Opposition: The ACA and the South [PDF]
, 2014 This report is part of a series of 21 state and regional studies examining the rollout of the ACA. The national network ---- with 36 states and 61 researchers ---- is led by the Rockefeller Institute of Government, the public policy research arm of the ...
Christopher Plein
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
, 2012 Source: Kurt Tucholsky: Gesammelte Werke in zehn Bänden. Herausgegeben von Mary Gerold-Tucholsky und Fritz J. Raddatz, Reinbek bei Hamburg: Rowohlt Verlag, 1975.
openaire +1 more source
Political Cycles : The Opposition Advantage [PDF]
We propose a two dimensional infinite horizon model of public consumption in which investments are decided by a winner-take-all election. Investments in the two public goods create a linkage across periods and parties have different specialities. We show
Pascal Gautier, Raphael Soubeyran
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Markedness Neutralisation and the Unity of Opposites in Heraclitus
Archai: Revista de Estudos sobre as Origens do Pensamento OcidentalIn this article, I shed new light on a misunderstood aspect of Heraclitus’ style. The opposites employed by Heraclitus are often of equal status except that one member of each pair may also appear as a designation for the encompassing whole.
Keith Begley
doaj +1 more source
Interpreting asteroid photometry and polarimetry using a model of shadowing and coherent backscattering [PDF]
The shadow-hiding models for the opposition effect and negative polarization of atmosphereless solar system bodies do not explain some experimental findings, such as the enhancing opposition effect and negative polarization with decreasing particle size ...
Muinonen, Karri, Shkuratov, Y. G.
core +1 more source