Results 101 to 110 of about 280,340 (213)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Classical vs. modern Squares of Opposition, and beyond
, 2012 The main difference between the classical Aristotelian square of oppo- sition and the modern one is not, as many seem to think, that the classical square has or presupposes existential import. The difference lies in the relations holding along the sides of
Westerståhl, Dag,
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Markedness Neutralisation and the Unity of Opposites in Heraclitus
Archai: Revista de Estudos sobre as Origens do Pensamento OcidentalIn this article, I shed new light on a misunderstood aspect of Heraclitus’ style. The opposites employed by Heraclitus are often of equal status except that one member of each pair may also appear as a designation for the encompassing whole.
Keith Begley
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Patriarchy Fights Back : Violent Opposition to Gender Equality in Online Contexts
, 2018 In contrast to the wealth of studies on progress towards gender equality, opposition to gender equality is rarely studied, which makes it difficult to understand the positive and negative dynamics of gender equality as a political project.The first of ...
Strid, Sofia,
core
Theoretical Issues and Oppositional Politics in East and Southeast Asia [PDF]
, 1995 Two decades ago political opposition in various parts of East and Southeast Asia was primarily characterised by peasant insurgencies and radical student movements questioning the very basis of the capitalist path to development.
Rodan, G.
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source