Results 101 to 110 of about 15,771 (212)

The Circadian Clock Gene Bmal1 Controls Thyroid Hormone-Mediated Spectral Identity and Cone Photoreceptor Function

Cell Reports, 2017
Circadian clocks regulate various aspects of photoreceptor physiology, but their contribution to photoreceptor development and function is unclear. Cone photoreceptors are critical for color vision.
Onkar B. Sawant, Amanda M. Horton, Olivia F. Zucaro, Ricky Chan, Vera L. Bonilha, Ivy S. Samuels, Sujata Rao   +6 more
doaj   +1 more source

Challenges for Therapeutic Applications of Opsin-Based Optogenetic Tools in Humans

Frontiers in Neural Circuits, 2020
As the technological hurdles are overcome and optogenetic techniques advance to have more control over neurons, therapies based on these approaches will begin to emerge in the clinic.
Yi Shen, Robert E. Campbell, Robert E. Campbell, Daniel C. Côté, Daniel C. Côté, Marie-Eve Paquet, Marie-Eve Paquet   +6 more
doaj   +1 more source

Opsin Expression in Human Epidermal Skin [PDF]

Photochemistry and Photobiology, 2014
AbstractHuman skin is constantly exposed to solar light containing visible and ultraviolet radiation (UVR), a powerful skin carcinogen. UVR elicits cellular responses in epidermal cells via several mechanisms: direct absorption of short‐wavelength UVR photons by DNA, oxidative damage caused by long‐wavelength UVR, and, as we recently demonstrated, via ...
Haltaufderhyde, Kirk, Ozdeslik, Rana N, Wicks, Nadine L, Najera, Julia A, Oancea, Elena   +4 more
openaire   +2 more sources

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Optogenetic methods and technologies in solving applied medical problems

Бюллетень сибирской медицины, 2020
Optogenetics is an innovative and fast-growing field of science combining the advances in molecular biology and laser technologies to monitor various biochemical processes in the cell and to control its activity using light.
L. E. Sorokina, V. I. Petrenko, M. V. Subbotkin, A. A. Kulanova, A. S. Kucherenko, A. V. Kubyshkin, I. I. Fomochkina, A. Yu. Nomerovskaya, S. I. Halilov   +8 more
doaj   +1 more source

The evolution of insect visual opsin genes with specific consideration of the influence of ocelli and life history traits

BMC Ecology and Evolution, 2022
Background Visual opsins are expressed in the compound eyes and ocelli of insects and enable light detection. Three distinct phylogenetic groups of visual opsins are found in insects, named long (LW), short (SW) and ultraviolet (UV) wavelength sensitive ...
Quentin Guignard, Jeremy D. Allison, Bernard Slippers   +2 more
doaj   +1 more source

Penaeid shrimp genome provides insights into benthic adaptation and frequent molting [PDF]

, 2019
Crustacea, the subphylum of Arthropoda which dominates the aquatic environment, is of major importance in ecology and fisheries. Here we report the genome sequence of the Pacific white shrimp Litopenaeus vannamei, covering similar to 1.66 Gb (scaffold ...
Alcivar-Warren, Acacia, Chen, Jack, Chu, Ka Hou, Gao, Yi, Jin, Songjun, Kong, Jie, Li, Fuhua, Li, Shihao, Lin, Wenchao, Liu, Bin, Liu, Chengzhang, Liu, Zhanjiang, Lv, Xinjia, Ma, Ka Yan, Ruan, Jue, Sagi, Amir, Sorgeloos, Patrick, Sun, Yamin, Wang, Lei, Wang, Long, Wang, Quanchao, Wang, Xiaobo, Xiang, Jianhai, Xu, Peng, Yu, Kuijie, Yu, Yang, Yuan, Jianbo, Zhang, Chengsong, Zhang, Hongbin, Zhang, Jiquan, Zhang, Xiaojun, Zhang, Xiaoxi, Zhu, Xueli   +32 more
core   +3 more sources

C-opsin Expressing Photoreceptors in Echinoderms [PDF]

Integrative and Comparative Biology, 2013
Today's progress in molecular analysis and, in particular, the increased availability of genome sequences have enabled us to investigate photoreceptor cells (PRCs) in organisms that were formerly inaccessible to experimental manipulation. Our studies of marine non-chordate deuterostomes thus aim to bridge a gap of knowledge regarding the evolution of ...
Esther M, Ullrich-Lüter, Salvatore, D'Aniello, Maria I, Arnone   +2 more
openaire   +2 more sources

Roles of ER Membrane Protein Complex in Protein Biogenesis and Quality Control in the Lung and Beyond

Cell Proliferation, EarlyView.
The endoplasmic reticulum membrane protein complex (EMC) is an evolutionarily conserved, multi‐subunit transmembrane protein complex crucial to membrane protein biogenesis and cellular protein quality control. This review systematically examines the structure, functions and disease‐associated regulatory mechanisms of EMC across multiple organ systems ...
Yan Qiao, Yuqing Sun, Yutao Huang, Qinghang Meng, Xinhua Lin, Wei Wei, Xiaofang Tang   +6 more
wiley   +1 more source

Olfactory, Taste, and Photo Sensory Receptors in Non-sensory Organs: It Just Makes Sense

Frontiers in Physiology, 2018
Sensory receptors that detect and respond to light, taste, and smell primarily belong to the G-protein-coupled receptor (GPCR) superfamily. In addition to their established roles in the nose, tongue, and eyes, these sensory GPCRs have been found in many ‘
Nicholas M. Dalesio, Nicholas M. Dalesio, Sebastian F. Barreto Ortiz, Jennifer L. Pluznick, Dan E. Berkowitz   +4 more
doaj   +1 more source