Results 111 to 120 of about 15,921 (237)
British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi +10 more
wiley +1 more source
Evolution and mechanism of spectral tuning of Blue-absorbing visual pigments in butterflies [PDF]
, 2010 The eyes of flower-visiting butterflies are often spectrally highly complex with multiple opsin genes generated by gene duplication, providing an interesting system for a comparative study of color vision.
ARIKAWA Kentaro +6 more
core +2 more sources
Journal of Anatomy, Volume 248, Issue 5, Page 784-805, May 2026.The expression of various genes involved in synapse development, stability and/or function was studied in developing mechanosensory neuromasts and electrosensory ampullary organs in sterlet sturgeon. Most were shared, including Slc17a8, Slc1a3 and Nrxn3, but Cbln18 was neuromast‐restricted and Tulp1 was ampullary organ‐restricted.
Alexander S. Campbell +6 more
wiley +1 more source
, 2013 The increasing interest in photoactivated proteins as natural replacement of standard inorganic materials in photocells drives to the compared analysis of bacteriorhodopsin and proteorhodopsin, two widely diffused proteins belonging to the family of ...
Alfinito, E +3 more
core +1 more source
Vision Research, 2011 Mouse cone photoreceptors, like those of most mammals including humans, express cone opsins derived from two ancient families: S-opsin (gene Opn1sw) and M-opsin (gene Opn1mw). Most C57Bl/6 mouse cones co-express both opsins, but in dorso-ventral counter-gradients, with M-opsin dominant in the dorsal retina and S-opsin in the ventral retina, and S-opsin
Daniele, Lauren L. +5 more
openaire +2 more sources
Struktureller Mechanismus eines Aktivitäts‐Photoschalters am β2‐adrenergen Rezeptor
Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.Zeitaufgelöste Strukturen aus Messungen an Röntgen‐Freie‐Elektronen‐Lasern in Kombination mit zellulären Assays zeigen, wie der photoschaltbare β‐Blocker Photoazolol‐1 als Wirksamkeits‐Photoschalter der Funktion des β2‐adrenergen Rezeptor wirkt. Die lichtinduzierte Neupositionierung des Liganden verschiebt die Aktivität von inversem Agonistimus hin zu ...
Robin Stipp +29 more
wiley +1 more source
BiP prevents rod opsin aggregation
Molecular Biology of the Cell, 2012 Mutations in rod opsin—the light-sensitive protein of rod cells—cause retinitis pigmentosa. Many rod opsin mutations lead to protein misfolding, and therefore it is important to understand the role of molecular chaperones in rod opsin biogenesis. We show that BiP (HSPA5) prevents the aggregation of rod opsin.
Athanasiou, D. +7 more
openaire +3 more sources
Structural Mechanism of an Efficacy Photoswitch Targeting the β2‐adrenergic Receptor
Angewandte Chemie International Edition, Volume 65, Issue 18, 27 April 2026.Time‐resolved structures from x‐ray free‐electron laser measurements combined with cellular assays demonstrate how the photoswitchable β‐blocker photoazolol‐1 acts as an efficacy switch of β2‐adrenergic receptor function. Light‐induced ligand repositioning shifts activity from inverse agonism toward neutral antagonism by altering local helical ...
Robin Stipp +29 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 7, 15 April 2026.We investigated the roles of PKM2, PKM1, and LDHA in retinal metabolism and structural integrity. In the normal retina, these enzymes are maintained at defined levels that support photoreceptor function. Rod‐specific deletion of LDHA, alone or with PKM2, caused age‐dependent degeneration, as PKM1 induction did not reach levels comparable to PKM2.
Ammaji Rajala +3 more
wiley +1 more source
Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety
Advanced Science, Volume 13, Issue 24, 27 April 2026.This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi +15 more
wiley +1 more source