Results 1 to 10 of about 41,721 (227)
LEDGF(1-326) decreases P23H and wild type rhodopsin aggregates and P23H rhodopsin mediated cell damage in human retinal pigment epithelial cells. [PDF]
PLoS ONE, 2011 BackgroundP23H rhodopsin, a mutant rhodopsin, is known to aggregate and cause retinal degeneration. However, its effects on retinal pigment epithelial (RPE) cells are unknown. The purpose of this study was to determine the effect of P23H rhodopsin in RPE
Rinku Baid +4 more
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Rhodopsin molecular evolution from mouse to human phenylalanine 88 to leucine substitution enhances thermal stability and post-activation decay [PDF]
Scientific ReportsThe function of rod photoreceptors as dim light photon detectors depends critically on the molecular properties of their visual pigment, rhodopsin. The structure of rhodopsin has evolved under selective pressure to light conditions of different spectral ...
Feifei Wang +6 more
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Scientific Reports, 2022 Rhodopsin is essential for phototransduction, and many rhodopsin mutations cause heritable retinal degenerations. The P23H rhodopsin variant generates a misfolded rhodopsin protein that photoreceptors quickly target for degradation by mechanisms that are
Kyle Kim +5 more
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PLoS ONE, 2023 We aimed to verify whether the intravitreal injection of small molecule compounds alone can create photoreceptor cells in mouse models of retinal degeneration.
Yuya Fujii +3 more
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Discovery of a microbial rhodopsin that is the most stable in extreme environments
iScience, 2021 Summary: Microbial rhodopsin is a retinal protein that functions as an ion pump, channel, and sensory transducer, as well as a light sensor, as in biosensors and biochips.
Jin-gon Shim +9 more
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Scientific Reports, 2021 Retinitis Pigmentosa (RP) is a blinding disease that arises from loss of rods and subsequently cones. The P23H rhodopsin knock-in (P23H-KI) mouse develops retinal degeneration that mirrors RP phenotype in patients carrying the orthologous variant ...
Eun-Jin Lee +5 more
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STAR Protocols, 2022 Summary: Microbial rhodopsins are photoreceptive membrane proteins showing various light-dependent biological activities. Styrene-maleic acid (SMA) copolymers spontaneously form nanoscale lipid particles containing membrane proteins and associated lipids
Keiichi Kojima, Yuki Sudo
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Ion-pumping microbial rhodopsin protein classification by machine learning approach
BMC Bioinformatics, 2023 Background Rhodopsin is a seven-transmembrane protein covalently linked with retinal chromophore that absorbs photons for energy conversion and intracellular signaling in eukaryotes, bacteria, and archaea.
Muthu Krishnan Selvaraj +6 more
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Violet light down-regulates the expression of specific differentiation markers through Rhodopsin in normal human epidermal keratinocytes. [PDF]
PLoS ONE, 2013 Several recent reports have demonstrated that photoreceptors are expressed in human skin. The rod and cone photoreceptor-like proteins are expressed in human skin and rhodopsin, long wavelength-opsin, and short wavelength-opsin are also present in ...
Hyoung-June Kim +5 more
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Accumulation of rhodopsin in late endosomes triggers photoreceptor cell degeneration. [PDF]
PLoS Genetics, 2009 Progressive retinal degeneration is the underlying feature of many human retinal dystrophies. Previous work using Drosophila as a model system and analysis of specific mutations in human rhodopsin have uncovered a connection between rhodopsin endocytosis
Yashodhan Chinchore +2 more
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