Results 1 to 10 of about 60,961 (150)
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser [PDF]
Nature, 2015 G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins. Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous G-protein-independent pathways.
Yanyong Kang, X Edward Zhou, Xiang Gao
exaly +3 more sources
Unexpected microbial rhodopsin dynamics in sync with phytoplankton blooms [PDF]
Nature CommunicationsThe surface ocean is the largest sunlit environment on Earth where marine microalgae are known as the main drivers of global productivity. However, rhodopsin phototrophs are actually the most abundant metabolic group, suggesting a major role in the ...
Laura Gómez-Consarnau +9 more
doaj +2 more sources
Rhodopsin molecular evolution from mouse to human phenylalanine 88 to leucine substitution enhances thermal stability and post-activation decay [PDF]
Scientific ReportsThe function of rod photoreceptors as dim light photon detectors depends critically on the molecular properties of their visual pigment, rhodopsin. The structure of rhodopsin has evolved under selective pressure to light conditions of different spectral ...
Feifei Wang +6 more
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Stabilizing effects of geraniol on native and pathogenic M39R rhodopsin variants [PDF]
Frontiers in NeuroscienceIntroductionMutations in rhodopsin are a major cause of autosomal dominant retinitis pigmentosa, frequently due to protein misfolding and reduced structural stability.
Pol Fernandez-Gonzalez +4 more
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A key amino acid site associated with rhodopsin mammal evolution to diurnal vision [PDF]
Scientific ReportsRhodopsin is a photoreceptor protein found in the vertebrate retina used as a landmark for vision evolution studies at the molecular level. Here, we examined the biochemical and functional performance of modern rhodopsin from three different mammal ...
Miguel A. Fernández-Sampedro +4 more
doaj +2 more sources
Scientific Reports, 2022 Rhodopsin is essential for phototransduction, and many rhodopsin mutations cause heritable retinal degenerations. The P23H rhodopsin variant generates a misfolded rhodopsin protein that photoreceptors quickly target for degradation by mechanisms that are
Kyle Kim +5 more
doaj +1 more source
PLoS ONE, 2023 We aimed to verify whether the intravitreal injection of small molecule compounds alone can create photoreceptor cells in mouse models of retinal degeneration.
Yuya Fujii +3 more
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Discovery of a microbial rhodopsin that is the most stable in extreme environments
iScience, 2021 Summary: Microbial rhodopsin is a retinal protein that functions as an ion pump, channel, and sensory transducer, as well as a light sensor, as in biosensors and biochips.
Jin-gon Shim +9 more
doaj +1 more source
Scientific Reports, 2021 Retinitis Pigmentosa (RP) is a blinding disease that arises from loss of rods and subsequently cones. The P23H rhodopsin knock-in (P23H-KI) mouse develops retinal degeneration that mirrors RP phenotype in patients carrying the orthologous variant ...
Eun-Jin Lee +5 more
doaj +1 more source
STAR Protocols, 2022 Summary: Microbial rhodopsins are photoreceptive membrane proteins showing various light-dependent biological activities. Styrene-maleic acid (SMA) copolymers spontaneously form nanoscale lipid particles containing membrane proteins and associated lipids
Keiichi Kojima, Yuki Sudo
doaj +1 more source