Results 41 to 50 of about 61,046 (231)

Unique Cl– pump rhodopsin with close similarity to H+ pump rhodopsin

Biophysics and Physicobiology, 2022
Microbial rhodopsin is a ubiquitous membrane protein in unicellular microorganisms. Similar to animal rhodopsin, this protein consists of seven transmembrane helices and the chromophore retinal.
Takashi Kikukawa
doaj   +1 more source

Subcellular localization of mutant P23H rhodopsin in an RFP fusion knock-in mouse model of retinitis pigmentosa

Disease Models & Mechanisms, 2022
The P23H mutation in rhodopsin (Rho), the rod visual pigment, is the most common allele associated with autosomal-dominant retinitis pigmentosa (adRP). The fate of misfolded mutant Rho in rod photoreceptors has yet to be elucidated.
Michael A. Robichaux, Vy Nguyen, Fung Chan, Lavanya Kailasam, Feng He, John H. Wilson, Theodore G. Wensel   +6 more
doaj   +1 more source

Phylogenomic analysis reveals extensive phylogenetic mosaicism in the Human GPCR Superfamily [PDF]

, 2007
A novel high throughput phylogenomic analysis (HTP) was applied to the rhodopsin G-protein coupled receptor (GPCR) family. Instances of phylogenetic mosaicism between receptors were found to be frequent, often as instances of correlated mosaicism and ...
Allaby, Robin G., Woodwark, Mathew
core   +1 more source

Polyphenols and Visual Health: Potential Effects on Degenerative Retinal Diseases

Molecules, 2021
Dietary polyphenols are a group of natural compounds that have been proposed to have beneficial effects on human health. They were first known for their antioxidant properties, but several studies over the years have shown that these compounds can exert ...
Pol Fernandez-Gonzalez, Aina Mas-Sanchez, Pere Garriga   +2 more
doaj   +1 more source

Rhodopsin/Lipid Hydrophobic Matching—Rhodopsin Oligomerization and Function [PDF]

Biophysical Journal, 2015
Lipid composition of the membrane and rhodopsin packing density strongly modulate the early steps of the visual response of photoreceptor membranes. In this study, lipid-order and bovine rhodopsin function in proteoliposomes composed of the sn-1 chain perdeuterated lipids 14:0d27-14:1-PC, 16:0d31-16:1-PC, 18:0d35-18:1-PC, or 20:0d39-20:1-PC at ...
Soubias, Olivier, Teague, Walter E., Hines, Kirk G., Gawrisch, Klaus   +3 more
openaire   +2 more sources

Neuroinflammation as a Therapeutic Target in Retinitis Pigmentosa and Quercetin as Its Potential Modulator

Pharmaceutics, 2021
The retina is a multilayer neuronal tissue located in the back of the eye that transduces the environmental light into a neural impulse. Many eye diseases caused by endogenous or exogenous harm lead to retina degeneration with neuroinflammation being a ...
Joseph Thomas Ortega, Beata Jastrzebska
doaj   +1 more source

Novel role for the innate immune receptor toll-like receptor 4 (TLR4) in the regulation of the wnt signaling pathway and photoreceptor apoptosis [PDF]

, 2012
Recent evidence has implicated innate immunity in regulating neuronal survival in the brain during stroke and other neurodegenerations. Photoreceptors are specialized light-detecting neurons in the retina that are essential for vision.
A Poltorak, A Wenzel, Abigail S. Hackam, AK Silva, AL Kindzelskii, Amit K. Patel, AO Edwards, AS Hackam, B Marsh, BJ Marsh, BJ Marsh, C Bowes, C Liu, C Niehrs, C Zhang, Chhinder P. Sodhi, CP Sodhi, CY Logan, D Jiang, David J. Hackam, DJ Kaczorowski, E Cario, E Chaum, E Okun, F Hua, F Limana, G Faraco, G Tezel, GA Limb, GM Seigel, GR Barile, GS Hageman, GT Higgins, H Yi, H Yi, HL Rosenzweig, HL Rosenzweig, HP Scholl, Hyun Yi, IA El-Ghrably, J Merenmies, J Qiu, J Watson, JK Shen, JR Caso, K Hoshino, K Kaarniranta, K Miyake, K Takeda, KP Mollen, L Barandon, L Minghetti, M Mizukami, MA Fragoso, Mauricio Martins Rodrigues, MD Gordon, MK Ko, MT Lotze, N Arimura, P Matzinger, PJ Franco, PY Leung, Q Xing, R Gauthier, R Gorina, R Kacimi, R Seitz, R Shechter, RM Vabulas, RR Caspi, RT Moon, S Lehnardt, S Lin, S Tell, S Walter, S Zareparsi, SC Gribar, SC Tang, SC Tang, SR Coats, T Ha, T Harada, T Harada, T Nakazawa, U Kilic, V Bocchini, V Fontaine, Y de Kozak, Y Xin, Z Tu   +89 more
core   +5 more sources

Plasmonic Enhancement of Fluorescence and Protein Dynamics in Living Mammalian Cells

Advanced Materials, EarlyView.
This study demonstrates plasmonic enhancement of the function of fluorescent voltage sensing proteins (genetically encoded voltage indicators, (GEVIs), QuasAr6) in live mammalian cells. Coupling to plasmonic nanoparticles does not just increase fluorescence, but influences the protein photocycle, creating a hybrid sensor with its response speed to ...
Marco Locarno, Qiangrui Dong, Marco Post, Xin Meng, Cristiano Glessi, Nynke Marije Hettema, Nidas Brandsma, Sebbe Blokhuizen, Alejandro Castañeda Garcia, Srividya Ganapathy, Thieme Schmidt, Lars van Roemburg, Bing Xu, Chun‐Ting Cho, Liedewij Laan, Miao‐Ping Chien, Daan Brinks   +16 more
wiley   +1 more source

Omega Rhodopsins: A Versatile Class of Microbial Rhodopsins

Journal of Microbiology and Biotechnology, 2020
Microbial rhodopsins are a superfamily of photoactive membrane proteins with covalently bound retinal cofactor. Isomerization of the retinal chromophore upon absorption of a photon triggers conformational changes of the protein to function as ion pumps or sensors.
Kwon, Soon-Kyeong, Jun, Sung-Hoon, Kim, Jihyun F.   +2 more
openaire   +3 more sources

Optogenetic manipulation of neuronal and cardiomyocyte functions in zebrafish using microbial rhodopsins and adenylyl cyclases

eLife, 2023
Even though microbial photosensitive proteins have been used for optogenetics, their use should be optimized to precisely control cell and tissue functions in vivo.
Hanako Hagio, Wataru Koyama, Shiori Hosaka, Aysenur Deniz Song, Janchiv Narantsatsral, Koji Matsuda, Takashi Shimizu, Shoko Hososhima, Satoshi P Tsunoda, Hideki Kandori, Masahiko Hibi   +10 more
doaj   +1 more source