Results 51 to 60 of about 38,017 (242)

Rhodopsin-Like Ionic Gate Fabricated with Graphene Oxide and Isomeric DNA Switch for Efficient Photocontrol of Ion Transport

, 2019
Rhodopsin, composed of opsin and isomeric retinal, acts as the primary photoreceptor by converting light into electric signals. Inspired by rhodopsin, we have fabricated a light-regulated ionic gate on the basis of the design of a graphene oxide (GO ...
Tao Gao (1424974), Genxi Li (1410568), Anzhi Sheng (6686633), Tianshu Chen (4067680), Liu Shi, Tao Gao, Jie Yang (121778), Wenxin Chai (4897090), Jie Yang, Chaoli Mu (6686630), Chaoli Mu, Anzhi Sheng, Genxi Li, Xiaoli Zhu (767993), Liu Shi (1952005), Xiaoli Zhu, Tianshu Chen, Wenxin Chai   +17 more
core   +1 more source

Flotillin-associated rhodopsin (FArhodopsin), a widespread paralog of proteorhodopsin in aquatic bacteria with streamlined genomes

mSystems, 2023
Microbial rhodopsins are found more than once in a single genome (paralogs) often have different functions. We screened a large dataset of open ocean single-amplified genomes (SAGs) for co-occurrences of multiple rhodopsin genes.
Jose M. Haro-Moreno, Mario López-Pérez, Alexey Alekseev, Elizaveta Podoliak, Kirill Kovalev, Valentin Gordeliy, Ramunas Stepanauskas, Francisco Rodriguez-Valera   +7 more
doaj   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin.

PLoS ONE, 2019
Mutations in the RHO gene encoding for the visual pigment protein, rhodopsin, are among the most common cause of autosomal dominant retinitis pigmentosa (ADRP).
James Mitchell, Fernanda Balem, Kalyan Tirupula, David Man, Harpreet Kaur Dhiman, Naveena Yanamala, Julian Ollesch, Joan Planas-Iglesias, Barbara J Jennings, Klaus Gerwert, Alessandro Iannaccone, Judith Klein-Seetharaman   +11 more
doaj   +1 more source

Membrane Protein Activity Induces Specific Molecular Changes in Nanodiscs Monitored by FTIR Difference Spectroscopy

Frontiers in Molecular Biosciences, 2022
It is well known that lipids neighboring integral membrane proteins directly influence their function. The opposite effect is true as well, as membrane proteins undergo structural changes after activation and thus perturb the lipidic environment.
Federico Baserga, Antreas Vorkas, Fucsia Crea, Luiz Schubert, Jheng-Liang Chen, Aoife Redlich, Mariafrancesca La Greca, Julian Storm, Sabine Oldemeyer, Kirsten Hoffmann, Ramona Schlesinger, Joachim Heberle   +11 more
doaj   +1 more source

Sterisch überfrachtete Alken‐Photo‐Redox‐Schalter auf Basis von Chinolinium/Carben Bausteinen

Angewandte Chemie, EarlyView.
Eine modulare Synthese einer neuen Klasse von Photo‐ und Redox‐Schaltern wird beschrieben, die auf der Kombination von Chinoliniumsalzen und Carbenen basiert. Das photochemische Schalten ermöglicht einen selektiven Wechsel zwischen gefalteten E/Z‐Isomeren, während das elektrochemische Schalten den Wechsel zwischen neutralen, radikalkationischen und ...
Chris Burdenski, Patrick W. Antoni, Marcel E. Baumert, Leonie Ziemann, Samaresh C. Sau, Julian J. Holstein, Maria Castro, Nitin Kumar, Ofer Filiba, Igor Schapiro, Max M. Hansmann   +10 more
wiley   +1 more source

New spectral templates for rhodopsin and porphyropsin visual pigments [PDF]

Archives of Biological Sciences, 2019
A four-parameter model of spectral sensitivity curves was developed. Empirical equations were designed for A1- and A2-based visual pigments with the main α-band maximum absorptions (λmax) from 350 nm, near the ultraviolet, up to 635 nm in the far-red ...
Gačić Zoran, Mićković Branislav, Gačić Luka, Damjanović Ilija   +3 more
doaj   +1 more source

Overcrowded Alkene Photo‐Redox‐Switches Based on Quinolinium/Carbene Building Blocks

Angewandte Chemie International Edition, EarlyView.
A modular synthesis of a new class of photo‐ and redox‐switches is described based on the combination of quinolinium salts and carbenes. Photochemical switching allows to selectively switch between folded E/Z isomers, while electrochemical switching allows to change between neutral, radical cation and dicationic oxidation states, which are all isolable
Chris Burdenski, Patrick W. Antoni, Marcel E. Baumert, Leonie Ziemann, Samaresh C. Sau, Julian J. Holstein, Maria Castro, Nitin Kumar, Ofer Filiba, Igor Schapiro, Max M. Hansmann   +10 more
wiley   +1 more source

A Y178C rhodopsin mutation causes aggregation and comparatively severe retinal degeneration

Cell Death Discovery
Rhodopsin is the light-activated G protein-coupled receptor that initiates vision in photoreceptor cells of the retina. Numerous mutations in rhodopsin promote receptor misfolding and aggregation, causing autosomal dominant retinitis pigmentosa, a ...
Sreelakshmi Vasudevan, Paul S.–H. Park
doaj   +1 more source