Results 61 to 70 of about 41,721 (227)

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

The Activation Pathway of Human Rhodopsin in Comparison to Bovine Rhodopsin [PDF]

Journal of Biological Chemistry, 2015
Rhodopsin, the photoreceptor of rod cells, absorbs light to mediate the first step of vision by activating the G protein transducin (Gt). Several human diseases, such as retinitis pigmentosa or congenital night blindness, are linked to rhodopsin malfunctions. Most of the corresponding in vivo studies and structure-function analyses (e.g.
Roman, Kazmin, Alexander, Rose, Michal, Szczepek, Matthias, Elgeti, Eglof, Ritter, Ronny, Piechnick, Klaus Peter, Hofmann, Patrick, Scheerer, Peter W, Hildebrand, Franz J, Bartl   +9 more
openaire   +2 more sources

New spectral templates for rhodopsin and porphyropsin visual pigments [PDF]

Archives of Biological Sciences, 2019
A four-parameter model of spectral sensitivity curves was developed. Empirical equations were designed for A1- and A2-based visual pigments with the main α-band maximum absorptions (λmax) from 350 nm, near the ultraviolet, up to 635 nm in the far-red ...
Gačić Zoran, Mićković Branislav, Gačić Luka, Damjanović Ilija   +3 more
doaj   +1 more source

Associations between intake of vitamins E and A and serum concentrations in preterm infants: A retrospective cohort study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Infants in neonatal intensive care are at risk of both deficiency and excess of fat‐soluble vitamins, particularly E and A, due to limited reserves and the need for prolonged intravenous nutrition. We aimed to determine the effects of increased intravenous vitamin intake and to characterise the relationships between vitamin intake ...
A. Bronnert, L. Kremer, JE Harding, FH Bloomfield, B. E. Cormack   +4 more
wiley   +1 more source

Rhodopsin/Lipid Hydrophobic Matching—Rhodopsin Oligomerization and Function [PDF]

Biophysical Journal, 2015
Lipid composition of the membrane and rhodopsin packing density strongly modulate the early steps of the visual response of photoreceptor membranes. In this study, lipid-order and bovine rhodopsin function in proteoliposomes composed of the sn-1 chain perdeuterated lipids 14:0d27-14:1-PC, 16:0d31-16:1-PC, 18:0d35-18:1-PC, or 20:0d39-20:1-PC at ...
Soubias, Olivier, Teague, Walter E., Hines, Kirk G., Gawrisch, Klaus   +3 more
openaire   +2 more sources

Membrane Protein Activity Induces Specific Molecular Changes in Nanodiscs Monitored by FTIR Difference Spectroscopy

Frontiers in Molecular Biosciences, 2022
It is well known that lipids neighboring integral membrane proteins directly influence their function. The opposite effect is true as well, as membrane proteins undergo structural changes after activation and thus perturb the lipidic environment.
Federico Baserga, Antreas Vorkas, Fucsia Crea, Luiz Schubert, Jheng-Liang Chen, Aoife Redlich, Mariafrancesca La Greca, Julian Storm, Sabine Oldemeyer, Kirsten Hoffmann, Ramona Schlesinger, Joachim Heberle   +11 more
doaj   +1 more source

Keeping It Native: Non‐Denaturing Approaches to Top‐Down Protein Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics and top‐down mass spectrometry approaches provide direct characterization of proteoforms; the specific molecular forms of proteins, including post‐translational modifications, truncations, alternative splicing, and sequence variants.
Michael Xiao, Edvaldo Vasconcelos Soares Maciel, Frederik Lermyte, Owen S. Skinner   +3 more
wiley   +1 more source

Structure and function in rhodopsin: Asymmetric reconstitution of rhodopsin in liposomes [PDF]

Proceedings of the National Academy of Sciences, 2002
We report on preparation of rhodopsin proteoliposomes with the cytoplasmic domain of rhodopsin facing the exterior of the proteoliposomes. Rhodopsin purified from rod outer segments of bovine retinae by immunoaffinity chromatography in octyl glucoside was reconstituted into liposomes prepared from soybean phospholipids by detergent
Li, Niu, Jong-Myoung, Kim, H Gobind, Khorana   +2 more
openaire   +2 more sources

Optical Control of Therapeutic Synthetic Cells: Controlling Biomolecule Synthesis, Activation, and Communication

Small Methods, EarlyView.
Combining synthetic cells engineering, cell‐free expression, and optical regulation may enable a new generation of programmable synthetic cell platforms. By providing spatiotemporal control over biomolecule synthesis, activation, transport, release, and communication, light offers a versatile strategy for coordinating proteins, RNAs, peptides, and ...
Gia Bao Leon Hoang, Taniya Chakraborty
wiley   +1 more source

Rhodopsin Signaling and Organization in Heterozygote Rhodopsin Knockout Mice [PDF]

Journal of Biological Chemistry, 2004
Rhodopsin (Rho) resides within internal membrane structures called disc membranes that are found in the rod outer segments (ROS) of photoreceptors in the retina. Rho expression is essential for formation of ROS, which are absent in knockout Rho-/- mice.
Liang, Y., Fotiadis, D., Maeda, T., Maeda, A., Modzelewska, A., Filipek, S., Saperstein, D. A., Engel, A., Palczewski, K.   +8 more
openaire   +2 more sources