Negative regulation of the novel norpA(P24) suppressor, diehard4, in the endo-lysosomal trafficking underlies photoreceptor cell degeneration. [PDF]
PLoS Genetics, 2013 Rhodopsin has been used as a prototype system to investigate G protein-coupled receptor (GPCR) internalization and endocytic sorting mechanisms. Failure of rhodopsin recycling upon light activation results in various degenerative retinal diseases ...
Jongwoo Lee +2 more
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Coexpression of spectrally distinct rhodopsins in Aedes aegypti R7 photoreceptors. [PDF]
PLoS ONE, 2011 The retina of the mosquito Aedes aegypti can be divided into four regions based on the non-overlapping expression of a UV sensitive Aaop8 rhodopsin and a long wavelength sensitive Aaop2 type rhodopsin in the R7 photoreceptors.
Xiaobang Hu +4 more
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Binding of rhodopsin and rhodopsin analogues to transducin, rhodopsin kinase and arrestin-1
World Journal of Biological Chemistry, 2014 Laparoscopic surgery is the main treatment method for patients with gastrointestinal malignant tumors. Although laparoscopic surgery is minimally invasive, its tool stimulation and pneumoperitoneum pressure often cause strong stress reactions in patients. On the other hand, gastrointestinal surgery can cause stronger pain in patients, compared to other
Nelson A, Araujo +2 more
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Functional analysis of A 5' untranslated variant in rhodopsin : implications for the retinitis pigmentosa phenotype [PDF]
, 2011 Retinitis Pigmentosa (RP) is a group of heterogeneous retinal degenerative diseases that predominantly affect rod photoreceptor cells. Symptoms include night blindness and gradual peripheral vision loss, which progresses to a complete loss of vision ...
Akinyi, Maureen Veronica
core +1 more source
Rescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation.
PLoS ONE, 2011 The P23H mutation in the rhodopsin gene causes rhodopsin misfolding, altered trafficking and formation of insoluble aggregates leading to photoreceptor degeneration and autosomal dominant retinitis pigmentosa (RP).
Vidyullatha Vasireddy +8 more
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Omega Rhodopsins: A Versatile Class of Microbial Rhodopsins
Journal of Microbiology and Biotechnology, 2020 Microbial rhodopsins are a superfamily of photoactive membrane proteins with covalently bound retinal cofactor. Isomerization of the retinal chromophore upon absorption of a photon triggers conformational changes of the protein to function as ion pumps or sensors.
Kwon, Soon-Kyeong +2 more
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Evolutionary history of teleost intron-containing and intron-less rhodopsin genes
Scientific Reports, 2019 Recent progress in whole genome sequencing has revealed that animals have various kinds of opsin genes for photoreception. Among them, most opsin genes have introns in their coding regions.
Chihiro Fujiyabu +5 more
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Unique Cl– pump rhodopsin with close similarity to H+ pump rhodopsin
Biophysics and Physicobiology, 2022 Microbial rhodopsin is a ubiquitous membrane protein in unicellular microorganisms. Similar to animal rhodopsin, this protein consists of seven transmembrane helices and the chromophore retinal.
Takashi Kikukawa
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Disease Models & Mechanisms, 2022 The P23H mutation in rhodopsin (Rho), the rod visual pigment, is the most common allele associated with autosomal-dominant retinitis pigmentosa (adRP). The fate of misfolded mutant Rho in rod photoreceptors has yet to be elucidated.
Michael A. Robichaux +6 more
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Polyphenols and Visual Health: Potential Effects on Degenerative Retinal Diseases
Molecules, 2021 Dietary polyphenols are a group of natural compounds that have been proposed to have beneficial effects on human health. They were first known for their antioxidant properties, but several studies over the years have shown that these compounds can exert ...
Pol Fernandez-Gonzalez +2 more
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