PLoS Genetics, 2021 Color vision in Drosophila melanogaster is based on the expression of five different color-sensing Rhodopsin proteins in distinct subtypes of photoreceptor neurons.
Clara Poupault +8 more
doaj +1 more source
Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in mice. [PDF]
PLoS ONE, 2014 For sensitive detection of rare gene repair events in terminally differentiated photoreceptors, we generated a knockin mouse model by replacing one mouse rhodopsin allele with a form of the human rhodopsin gene that causes a severe, early-onset form of ...
Ivette M Sandoval +6 more
doaj +1 more source
An Olfactory Receptor Pseudogene whose Function emerged in Humans [PDF]
, 2007 Human olfactory receptor, hOR17-210, is identified as a pseudogene in the human genome. Experimental data has shown however, that the gene product of cloned hOR17-210 cDNA was able to bind an odorant-binding protein and is narrowly tuned for excitation ...
Catherine Ronin +6 more
core +2 more sources
Negative regulation of the novel norpA(P24) suppressor, diehard4, in the endo-lysosomal trafficking underlies photoreceptor cell degeneration. [PDF]
PLoS Genetics, 2013 Rhodopsin has been used as a prototype system to investigate G protein-coupled receptor (GPCR) internalization and endocytic sorting mechanisms. Failure of rhodopsin recycling upon light activation results in various degenerative retinal diseases ...
Jongwoo Lee +2 more
doaj +1 more source
Rescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation.
PLoS ONE, 2011 The P23H mutation in the rhodopsin gene causes rhodopsin misfolding, altered trafficking and formation of insoluble aggregates leading to photoreceptor degeneration and autosomal dominant retinitis pigmentosa (RP).
Vidyullatha Vasireddy +8 more
doaj +1 more source
Early stages of retinal development depend on Sec13 function [PDF]
, 2013 Summary ER-to-Golgi transport of proteins destined for the extracellular space or intracellular compartments depends on the COPII vesicle coat and is constitutive in all translationally active cells.
Cavodeassi, Florencia +3 more
core +3 more sources
Coexpression of spectrally distinct rhodopsins in Aedes aegypti R7 photoreceptors. [PDF]
PLoS ONE, 2011 The retina of the mosquito Aedes aegypti can be divided into four regions based on the non-overlapping expression of a UV sensitive Aaop8 rhodopsin and a long wavelength sensitive Aaop2 type rhodopsin in the R7 photoreceptors.
Xiaobang Hu +4 more
doaj +1 more source
LipidāRhodopsin Hydrophobic Mismatch Alters Rhodopsin Helical Content [PDF]
Journal of the American Chemical Society, 2008 The ability of photoactivated rhodopsin to achieve the enzymatically active metarhodopsin II conformation is exquisitely sensitive to bilayer hydrophobic thickness. The sensitivity of rhodopsin to the lipid matrix has been explained by the hydrophobic matching theory, which predicts that lipid bilayers adjust elastically to the hydrophobic length of ...
Olivier, Soubias +3 more
openaire +2 more sources
Evolutionary history of teleost intron-containing and intron-less rhodopsin genes
Scientific Reports, 2019 Recent progress in whole genome sequencing has revealed that animals have various kinds of opsin genes for photoreception. Among them, most opsin genes have introns in their coding regions.
Chihiro Fujiyabu +5 more
doaj +1 more source
Optogenetics and deep brain stimulation neurotechnologies [PDF]
, 2015 Brain neural network is composed of densely packed, intricately wired neurons whose activity patterns ultimately give rise to every behavior, thought, or emotion that we experience. Over the past decade, a novel neurotechnique, optogenetics that combines
A Berndt +58 more
core +2 more sources