Results 21 to 30 of about 41,721 (227)

Biochemische und biophysikalische Charakterisierung von Rhodopsin-Guanylylzyklasen [PDF]

open access: yes, 2018
Rhodopsin-Guanylylzyklasen (RhGC) sind einzigartige Photorezeptoren, die kürzlich in Pilzen der Abteilung Blastocladiomycota entdeckt wurden [1]. RhGCs gehören zu den Enzym-Rhodopsinen und die Licht-sensitive mikrobielle Rhodopsin Domäne ist kovalent mit
Scheib, Ulrike
core   +1 more source

Rhodopsin expression level affects rod outer segment morphology and photoresponse kinetics. [PDF]

open access: yesPLoS ONE, 2012
The retinal rod outer segment is a sensory cilium that is specialized for the conversion of light into an electrical signal. Within the cilium, up to several thousand membranous disks contain as many as a billion copies of rhodopsin for efficient photon ...
Clint L Makino   +7 more
doaj   +1 more source

Retinitis pigmentosa: A Case Report with Thr17Arg as a Novel Mutation in RHO Gene. [PDF]

open access: yesJournal of Epigenetics, 2022
Background and Aim: Retinitis pigmentosa (RP) is the most common type of inherited progressive photoreceptor cells degeneration causing night blindness, progressive reduction of visual field, loss of retinal pigment epithelial function, and ultimately ...
sajjad Rafiee Komachali   +2 more
doaj   +1 more source

A large geometric distortion in the first photointermediate of rhodopsin, determined by double-quantum solid-state NMR [PDF]

open access: yes, 2012
Double-quantum magic-angle-spinning NMR experiments were performed on 11,12-C-13(2)-retinylidene-rhodopsin under illumination at low temperature, in order to characterize torsional angle changes at the C11-C12 photoisomerization site.
Johannessen, Ole G.   +13 more
core   +1 more source

Isoelectric Focusing to Quantify Rhodopsin Phosphorylation in Mouse Retina

open access: yesBio-Protocol, 2019
Rhodopsin is a G-protein coupled receptor (GPCR) that mediates vision under dim light. Upon light exposure, rhodopsin is phosphorylated at multiple serine and threonine sites at its carboxyl-terminus by rhodopsin kinase (GRK1). This, in turn, reduces its
Sowmya Bekshe Lokappa   +2 more
doaj   +1 more source

A combinatorial cis-regulatory logic restricts color-sensing Rhodopsins to specific photoreceptor subsets in Drosophila.

open access: yesPLoS Genetics, 2021
Color vision in Drosophila melanogaster is based on the expression of five different color-sensing Rhodopsin proteins in distinct subtypes of photoreceptor neurons.
Clara Poupault   +8 more
doaj   +1 more source

Highly sensitive visual restoration and protection via ectopic expression of chimeric rhodopsin in mice

open access: yesiScience, 2023
Summary: Photoreception requires amplification by mammalian rhodopsin through G protein activation, which requires a visual cycle. To achieve this in retinal gene therapy, we incorporated human rhodopsin cytoplasmic loops into Gloeobacter rhodopsin ...
Yusaku Katada   +9 more
doaj   +1 more source

Structure of rhodopsin [PDF]

open access: yesEye, 1998
Two-dimensional crystals of rhodopsin were studied to determine the arrangement of the transmembrane alpha helices. A combination of electron cryomicroscopy, image processing and electron crystallography was used to extract amplitudes and phases from images, and a three-dimensional map to a resolution of 7.5 A was calculated.
openaire   +3 more sources

Prediction of Structure, Function, and Spectroscopic Properties of G-Protein-Coupled Receptors: Methods and Applications [PDF]

open access: yes, 2004
G-protein-coupled receptors are of great pharmaceutical interest, comprising the majority of targets for currently marketed drugs. The theme of my thesis is the development of the structure prediction method, MembStruk, for the superfamily of G-protein ...
Trabanino, Rene Jouvanni
core   +1 more source

Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in mice. [PDF]

open access: yesPLoS ONE, 2014
For sensitive detection of rare gene repair events in terminally differentiated photoreceptors, we generated a knockin mouse model by replacing one mouse rhodopsin allele with a form of the human rhodopsin gene that causes a severe, early-onset form of ...
Ivette M Sandoval   +6 more
doaj   +1 more source

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