Results 21 to 30 of about 38,017 (242)

Rhodopsin Forms Nanodomains in Rod Outer Segment Disc Membranes of the Cold-Blooded Xenopus laevis. [PDF]

PLoS ONE, 2015
Rhodopsin forms nanoscale domains (i.e., nanodomains) in rod outer segment disc membranes from mammalian species. It is unclear whether rhodopsin arranges in a similar manner in amphibian species, which are often used as a model system to investigate the
Tatini Rakshit, Subhadip Senapati, Satyabrata Sinha, A M Whited, Paul S-H Park   +4 more
doaj   +1 more source

Retinitis pigmentosa: A Case Report with Thr17Arg as a Novel Mutation in RHO Gene. [PDF]

Journal of Epigenetics, 2022
Background and Aim: Retinitis pigmentosa (RP) is the most common type of inherited progressive photoreceptor cells degeneration causing night blindness, progressive reduction of visual field, loss of retinal pigment epithelial function, and ultimately ...
sajjad Rafiee Komachali, Zakieh Siahpoosh, Mansoor Salehi   +2 more
doaj   +1 more source

C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor

eLife, 2015
Rod photoreceptors generate measurable responses to single-photon activation of individual molecules of the G protein-coupled receptor (GPCR), rhodopsin.
Anthony W Azevedo, Thuy Doan, Hormoz Moaven, Iza Sokal, Faiza Baameur, Sergey A Vishnivetskiy, Kristoff T Homan, John JG Tesmer, Vsevolod V Gurevich, Jeannie Chen, Fred Rieke   +10 more
doaj   +1 more source

Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain

Nature Communications, 2023
Rhodopsin is a prototypical G protein-coupled receptor (GPCR) critical for vertebrate vision. Research on GPCR signaling states has been facilitated using llama-derived nanobodies (Nbs), some of which bind to the intracellular surface to allosterically ...
Arum Wu, David Salom, John D. Hong, Aleksander Tworak, Kohei Watanabe, Els Pardon, Jan Steyaert, Hideki Kandori, Kota Katayama, Philip D. Kiser, Krzysztof Palczewski   +10 more
doaj   +1 more source

A large geometric distortion in the first photointermediate of rhodopsin, determined by double-quantum solid-state NMR [PDF]

, 2012
Double-quantum magic-angle-spinning NMR experiments were performed on 11,12-C-13(2)-retinylidene-rhodopsin under illumination at low temperature, in order to characterize torsional angle changes at the C11-C12 photoisomerization site.
Johannessen, Ole G., Bovee-Geurts, Petra H. M., Brown, Richard C. D., DeGrip, Willem J., McLean, Neville, Concistre, M., Levitt, Malcolm H., Concistrè, Maria, Grip, W.J. de, Bovee-Geurts, P.H.M., Johannessen, O.G., McLean, N., Levitt, M.H., Brown, R.C.   +13 more
core   +1 more source

Automatic Rhodopsin Modeling with Multiple Protonation Microstates

, 2023
Automatic Rhodopsin Modeling (ARM) is a simulation protocol providing QM/MM models of rhodopsins, capable of reproducing experimental electronic absorption and emission trends.
Gustavo, Cardenas, Vincent, Ledentu, Nicolas, Ferré, Miquel, Huix-Rotllant, Massimo, Olivucci   +4 more
core   +1 more source

Rhodopsin gene expression determines rod outer segment size and rod cell resistance to a dominant-negative neurodegeneration mutant.

PLoS ONE, 2012
Two outstanding unknowns in the biology of photoreceptors are the molecular determinants of cell size, which is remarkably uniform among mammalian species, and the mechanisms of rod cell death associated with inherited neurodegenerative blinding diseases
Brandee A Price, Ivette M Sandoval, Fung Chan, Ralph Nichols, Ramon Roman-Sanchez, Theodore G Wensel, John H Wilson   +6 more
doaj   +1 more source

Structure of rhodopsin [PDF]

Eye, 1998
Two-dimensional crystals of rhodopsin were studied to determine the arrangement of the transmembrane alpha helices. A combination of electron cryomicroscopy, image processing and electron crystallography was used to extract amplitudes and phases from images, and a three-dimensional map to a resolution of 7.5 A was calculated.
openaire   +3 more sources

Biochemische und biophysikalische Charakterisierung von Rhodopsin-Guanylylzyklasen [PDF]

, 2018
Rhodopsin-Guanylylzyklasen (RhGC) sind einzigartige Photorezeptoren, die kürzlich in Pilzen der Abteilung Blastocladiomycota entdeckt wurden [1]. RhGCs gehören zu den Enzym-Rhodopsinen und die Licht-sensitive mikrobielle Rhodopsin Domäne ist kovalent mit
Scheib, Ulrike
core   +1 more source

Prediction of Structure, Function, and Spectroscopic Properties of G-Protein-Coupled Receptors: Methods and Applications [PDF]

, 2004
G-protein-coupled receptors are of great pharmaceutical interest, comprising the majority of targets for currently marketed drugs. The theme of my thesis is the development of the structure prediction method, MembStruk, for the superfamily of G-protein ...
Trabanino, Rene Jouvanni
core   +1 more source