Results 11 to 20 of about 61,046 (231)
Cell-Type-Dependent Metabolic Compensation Preserves Photoreceptor Survival Through Pyruvate Kinase Isoform Balance. [PDF]
FASEB JWe investigated the roles of PKM2, PKM1, and LDHA in retinal metabolism and structural integrity. In the normal retina, these enzymes are maintained at defined levels that support photoreceptor function. Rod‐specific deletion of LDHA, alone or with PKM2, caused age‐dependent degeneration, as PKM1 induction did not reach levels comparable to PKM2.
Rajala A +3 more
europepmc +2 more sources
Ion-pumping microbial rhodopsin protein classification by machine learning approach
BMC Bioinformatics, 2023 Background Rhodopsin is a seven-transmembrane protein covalently linked with retinal chromophore that absorbs photons for energy conversion and intracellular signaling in eukaryotes, bacteria, and archaea.
Muthu Krishnan Selvaraj +6 more
doaj +1 more source
Violet light down-regulates the expression of specific differentiation markers through Rhodopsin in normal human epidermal keratinocytes. [PDF]
PLoS ONE, 2013 Several recent reports have demonstrated that photoreceptors are expressed in human skin. The rod and cone photoreceptor-like proteins are expressed in human skin and rhodopsin, long wavelength-opsin, and short wavelength-opsin are also present in ...
Hyoung-June Kim +5 more
doaj +1 more source
Accumulation of rhodopsin in late endosomes triggers photoreceptor cell degeneration. [PDF]
PLoS Genetics, 2009 Progressive retinal degeneration is the underlying feature of many human retinal dystrophies. Previous work using Drosophila as a model system and analysis of specific mutations in human rhodopsin have uncovered a connection between rhodopsin endocytosis
Yashodhan Chinchore +2 more
doaj +1 more source
PLoS ONE, 2011 BackgroundP23H rhodopsin, a mutant rhodopsin, is known to aggregate and cause retinal degeneration. However, its effects on retinal pigment epithelial (RPE) cells are unknown. The purpose of this study was to determine the effect of P23H rhodopsin in RPE
Rinku Baid +4 more
doaj +1 more source
Microorganisms, 2021 The diversity of aerobic anoxygenic phototrophs (AAPs) and rhodopsin-containing bacteria in the surface microlayer, water column, and epilithic biofilms of Lake Baikal was studied for the first time, employing pufM and rhodopsin genes, and compared to ...
Agnia Dmitrievna Galachyants +11 more
doaj +1 more source
Gi- and Gs-coupled GPCRs show different modes of G-protein binding. [PDF]
, 2018 More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered.
Altenbach, Christian +7 more
core +1 more source
Rhodopsin Forms Nanodomains in Rod Outer Segment Disc Membranes of the Cold-Blooded Xenopus laevis. [PDF]
PLoS ONE, 2015 Rhodopsin forms nanoscale domains (i.e., nanodomains) in rod outer segment disc membranes from mammalian species. It is unclear whether rhodopsin arranges in a similar manner in amphibian species, which are often used as a model system to investigate the
Tatini Rakshit +4 more
doaj +1 more source
Retinitis pigmentosa: A Case Report with Thr17Arg as a Novel Mutation in RHO Gene. [PDF]
Journal of Epigenetics, 2022 Background and Aim: Retinitis pigmentosa (RP) is the most common type of inherited progressive photoreceptor cells degeneration causing night blindness, progressive reduction of visual field, loss of retinal pigment epithelial function, and ultimately ...
sajjad Rafiee Komachali +2 more
doaj +1 more source
Retinal location and structure in squid rhodopsin [PDF]
, 2021 In order to understand retinal we calculated the dihedral angles around carbon axis IOC-12C, since two different carbon sequences 9C-10C-11C-12C and 10C-11C-12C-13C exist. We also calculated the distances between two specified carbon pairs. Those results
Kito, Masashi +2 more
core