Results 131 to 140 of about 15,921 (237)

Epilepsy: Molecular Pathogenesis and Emerging Therapies

MedComm, Volume 7, Issue 4, April 2026.
Progress has been made in the molecular pathogenesis of epilepsy, revealing multiple therapeutic targets. Recent advances in pharmacology, materials science, and surgical technique, coupled with progress in targeted therapy and disruptive epilepsy network technology, have led to the emergence of innovative strategies for epilepsy treatment.
Wanbin Huang, Jiabin Zong, Yu Zhang, Ming Li, Songqing Pan, Zheman Xiao   +5 more
wiley   +1 more source

AAV8 vector induced gliosis following neuronal transgene expression

Frontiers in Neuroscience
IntroductionExpression of light sensitive ion channels by selected neurons has been achieved by viral mediated transduction with gene constructs, but for this to have therapeutic uses, for instance in treating epilepsy, any adverse effects of viral ...
Faye McLeod, Elaine McDermott, Shermin Mak, Darren Walsh, Mark Turnbull, Fiona E. N. LeBeau, Andrew Jackson, Andrew J. Trevelyan, Gavin J. Clowry   +8 more
doaj   +1 more source

Chromosome‐scale genome assembly of the South American fruit fly, Anastrepha fraterculus sp.1

Insect Science, Volume 33, Issue 2, Page 640-664, April 2026.
Anastrepha fraterculus sp. 1 is a major fruit fly pest in Argentina, currently controlled through chemical treatments and traps. This study aims to enhance the genomic understanding of this species to support the development of sterile insect technique as well as the use of innovative technologies.
Máximo Rivarola, Claudia A. Conte, Pierre Berube, Shu‐Huang Chen, M. Cecilia Giardini, Alejandra C. Scannapieco, Fabián H. Milla, María C. Soria, Romina M. Russo, Juan P. Wulff, Haig H. Djambazian, Rolando R. Pomar, Alfred M. Handler, Kostas Bourtzis, Ioannis Ragoussis, Silvia B. Lanzavecchia   +15 more
wiley   +1 more source

A Review of Adaptive Mechanisms in Fish Retinal Structure and Opsins Under Light Environment Regulation

Fishes
Light, as one of the most crucial environmental factors, plays an essential role in the growth, physiology, and evolutionary survival of fish. To cope with diverse light conditions in aquatic environments, fish adapt through photosensory systems composed
Zheng Zhang, Fan Fei, Liang Wang, Yunsong Rao, Wenyang Li, Xiaoqiang Gao, Ao Li, Baoliang Liu   +7 more
doaj   +1 more source

Heatwaves and Anthropogenic Light May Disrupt Phototaxis‐Based Behaviours That Regulate Early‐Life Migrations of Fish

Freshwater Biology, Volume 71, Issue 4, April 2026.
ABSTRACT Though many fish larvae exhibit phototaxis, its adaptive value is underexplored. Larval fish rely on cues to guide them to suitable nursery habitats and phototaxis enables larvae to react to environmental cues. In the Anthropocene, innate phototactic behaviour might also be disrupted via climate change and habitat alteration.
Barnaby John Roberts, Jan Baer, Albert Ros, Alexander Brinker   +3 more
wiley   +1 more source

A Novel Long Noncoding RNA–LNC000133 Associated With Steroid‐Induced Osteonecrosis of the Femoral Head Promotes Osteoblast Differentiation Through Bone Marrow Mesenchymal Stem Cells‐Derived Exosomes Pathway: A Bioinformatics Validation and Detailed Mechanistic Study

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT Steroid‐induced osteonecrosis of the femoral head (SONFH) is a debilitating disease caused by glucocorticoid abuse, characterized by complex pathogenesis and unclear molecular mechanisms. Dysfunction of bone marrow mesenchymal stem cells (BMSCs) and their exosome‐mediated signalling is a key contributor to SONFH, although the precise ...
Chengbin Yang, Tixiong Xia, Xi Li, Tong Chen, Yingxing Xu   +4 more
wiley   +1 more source

Multimodal Approach for Recalcitrant Melasma Using Picosecond Laser and Topical JAK Inhibition: A Case Report

Journal of Cosmetic Dermatology, Volume 25, Issue 4, April 2026.
ABSTRACT Background Melasma is a chronic hyperpigmentation disorder with high relapse rates, particularly in Fitzpatrick skin types III–V. Increasing evidence implicates cytokine‐driven inflammation and visible light–induced melanogenesis as key contributors to disease persistence.
Hasan Ashkanani, Maryam AlZaabi, Abdulaziz AlRasheed, Wael AlDaraji   +3 more
wiley   +1 more source

Comparative analysis of canonical and noncanonical rhodopsins in Amphidinium carterae and Karlodinium veneficum

Journal of Phycology, Volume 62, Issue 2, Page 360-376, April 2026.
Abstract Rhodopsins are ancient and versatile light‐sensitive proteins, widely distributed across microbial life. In dinoflagellates, however, their diversity and function remain poorly understood, owing to the lineage's extreme genomic divergence. Here, we surveyed the rhodopsin complements of two dinoflagellates, Amphidinium carterae and Karlodinium ...
Jens Wira, Miranda Judd, Anne Baldino, Tsvetan Bachvaroff, Allen R. Place   +4 more
wiley   +1 more source

Editorial: Optogenetics: An Emerging Approach in Cardiac Electrophysiology

Frontiers in Physiology, 2020
Christopher L.-H. Huang, Christopher L.-H. Huang, Emily A. Ferenczi, Ming Lei, Ming Lei   +4 more
doaj   +1 more source

In silico characterisation and chromosomal localisation of human RRH (peropsin) – implications for opsin evolution [PDF]

, 2003
Bellingham, J, Foster, R G, Wells, D J
core   +1 more source