Results 111 to 120 of about 23,776 (285)
Genetically‐targeted control of the spinal cord and peripheral nervous system
Journal of Intelligent Medicine, EarlyView.Application of genetically‐targeted stimulation for treating diseases or injuries outside the brain. Optogenetic and chemogenetic systems have been developed for dysfunction in the cochlea, spinal cord, dorsal root ganglia (DRGs), peripheral nerves, lower urinary tract, and enteric nervous system (ENS). Created with Biorender.com.
Anakaren Romero Lozano +3 more
wiley +1 more source
ZBED4, a cone and Müller cell protein in human retina, has a different cellular expression in mouse. [PDF]
, 2011 PurposeZBED4, a protein in cones and Müller cells of human retina, may play important functions as a transcriptional activator of genes expressed in those cells or as a co-activator/repressor of their nuclear hormone receptors.
Akhmedov, Novrouz B +3 more
core +1 more source
Nature as the observer: A simplified approach to the measurement problem and related issues [PDF]
arXiv, 2007 Several theories have been advanced recently which appear to offer a resolution to that portion of the measurement problem which previously dealt with a possible reduction of the state vector in a subjective fashion by the brain, mind or consciousness.
arxiv
Expression of visual and nonvisual opsins in American chameleon [PDF]
, 1997 We previously characterized five visual opsin genes of American chameleon (Anolis carolinensis). Here we report its nonvisual opsin gene orthologous to the chicken pineal gland-specific opsin (P-opsin) gene.
Kawamura, Shoji, Yokoyama, Shozo
core +1 more source
Chimeric human opsins as optogenetic light sensitisers
Journal of Experimental Biology, 2018 Human opsin-based photopigments have great potential as light-sensitisers, but their requirement for phototransduction cascade-specific second messenger proteins may restrict their functionality in non-native cell types.
Doron G Hickey +6 more
semanticscholar +1 more source
Light‐Activated Pharmacological Tools for Exploring the Cholinergic System
Medicinal Research Reviews, EarlyView.ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni +5 more
wiley +1 more source
The Microbial Opsin Family of Optogenetic Tools [PDF]
, 2011 The capture and utilization of light is an exquisitely evolved process. The single-component microbial opsins, although more limited than multicomponent cascades in processing, display unparalleled compactness and speed.
Berndt, Andre +12 more
core +1 more source
Recent Developments in the Optical Control of Adrenergic Signaling
Medicinal Research Reviews, EarlyView.ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi +4 more
wiley +1 more source
Human blue cone opsin regeneration involves secondary retinal binding with analog specificity [PDF]
, 2018 Human color vision is mediated by the red, green, and blue cone visual pigments. Cone opsins are G-protein-coupled receptors consisting of an opsin apoprotein covalently linked to the 11-cis-retinal chromophore.
Cordomi, Arnau +6 more
core +2 more sources
Diverse Distributions of Extraocular Opsins in Crustaceans, Cephalopods, and Fish.
Integrative and Comparative Biology, 2016 Non-visual and extraocular photoreceptors are common among animals, but current understanding linking molecular pathways to physiological function of these receptors is lacking.
Alexandra C. N. Kingston, T. Cronin
semanticscholar +1 more source