Results 1 to 10 of about 7,931 (169)
A novel and rapid method to purify the human complement opsonin C3b from human plasma [PDF]
Frontiers in ImmunologyComplement opsonin C3b is at the center of the complement cascade. All complement initiation pathways converge when convertases activate C3, converting it into the anaphylatoxin C3a and the opsonin C3b, which can attach to surfaces via its freshly ...
Christoph Q Schmidt
exaly +6 more sources
Journal of Immunology Research, 2021 We recently showed that both nontypeable Haemophilus influenzae (NTHi) and its surface plasminogen- (Plg-) binding proteins interact with lipoprotein(a) (Lp(a)) in a lysine-dependent manner.
Zhi Liu +6 more
doaj +2 more sources
Targeting the capsule of Klebsiella pneumoniae with a cationic CR3-binding protein enhances phagocytosis and promotes bacterial clearance and survival in a mouse sepsis model [PDF]
Frontiers in ImmunologyPlatelet Factor 4 (PF4), a cationic antimicrobial peptide, serves as a ligand for the myeloid-specific phagocytic receptor CR3 (Mac-1, CD11b/CD18). We previously demonstrated that recombinant dimeric PF4 (rPF4) functions as a bacterial opsonin, enhancing
Nataly P. Podolnikova +6 more
doaj +2 more sources
Protective role of Galectin-3 in prion disease through regulation of microglial PrP<sup>Sc</sup> uptake. [PDF]
Brain PatholGalectin‐3 (Gal3) is induced in reactive microglia during prion disease and promotes microglial uptake of PrPSc. Gal3 deficiency reduces prion sequestration and accelerates disease progression, revealing a protective role for Gal3. Abstract Microglia constitute a major innate defense mechanism against prion infection; however, the molecular pathways ...
Makarava N +8 more
europepmc +2 more sources
Microorganisms, 2020 Neutrophils are the most abundant innate cell population and a key immune player against invading pathogens. Neutrophils can kill both bacterium and spores of Bacillus anthracis, the causative anthrax pathogen.
Narcis I. Popescu +4 more
doaj +2 more sources
The Phagocytic Code Regulating Phagocytosis of Mammalian Cells
Frontiers in Immunology, 2021 Mammalian phagocytes can phagocytose (i.e. eat) other mammalian cells in the body if they display certain signals, and this phagocytosis plays fundamental roles in development, cell turnover, tissue homeostasis and disease prevention.
Tom O. J. Cockram +3 more
doaj +1 more source
Marine Drugs, 2022 Crustin are a family of antimicrobial peptides that play an important role in protecting against pathogens infection in the innate immune system of crustaceans.
Jie Hu +5 more
doaj +1 more source
Opsonins and Dysopsonins of Nanoparticles: Facts, Concepts, and Methodological Guidelines
Frontiers in Immunology, 2020 Understanding the effects mediated by a set of nanoparticle (NP)-bound host biomolecules, often indicated with the umbrella term of NP corona, is essential in nanomedicine, nanopharmacology, and nanotoxicology.
Emanuele Papini +4 more
doaj +1 more source
Nature Communications, 2022 Complement activation on foreign cell surfaces leads to the generation of complement opsonins, which activate complement receptor type 3 (CR3) and pathogen clearance by macrophages.
Francisco J. Fernández +9 more
doaj +1 more source
Global analysis of neutrophil responses to Neisseria gonorrhoeae reveals a self-propagating inflammatory program. [PDF]
PLoS Pathogens, 2014 An overwhelming neutrophil-driven response causes both acute symptoms and the lasting sequelae that result from infection with Neisseria gonorrhoeae. Neutrophils undergo an aggressive opsonin-independent response to N.
Anna Sintsova +8 more
doaj +1 more source