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Soluble MD-2 is an acute-phase protein and an opsonin for Gram-negative bacteria

Blood, 2008
Myeloid differentiation factor-2 (MD-2) is a lipopolysaccharide (LPS)-binding protein usually coexpressed with and binding to Toll-like receptor 4 (TLR4), conferring LPS responsiveness of immune cells. MD-2 is also found as a soluble protein. Soluble MD-2 (sMD-2) levels are markedly elevated in plasma from patients with severe infections, and in other ...
Pierre Tissieres   +2 more
exaly   +5 more sources

Protein corona meets freeze-drying: overcoming the challenges of colloidal stability, toxicity, and opsonin adsorption

Nanoscale, 2021
Freeze-drying of nanoparticle suspensions in presence of pre-formed protein corona is capable of generating stable nanoformulations with improved biocompatibility, longer storage times and easier transportation.
Agustin S. Picco   +5 more
openaire   +3 more sources

Effects of Staphylococcal Protein a on Heat Labile Opsonins

The Journal of Immunology, 1974
Abstract Staphylococcal protein A inhibited phagocytosis of Staphylococcus aureus and Escherichia coli in in vitro phagocytosis systems with normal human serum. Protein A had no effect on phagocytic cells per se, and produced inhibition of the heat labile opsonins, i.e., of the complement system in normal sera at low concentration.
A, Forsgren, P G, Quie
openaire   +2 more sources

Glycyrrhizic Acid-Lipid Framework Nanovehicle Loading Triptolide for Combined Immunochemotherapy.

ACS Applied Materials and Interfaces, 2023
Despite the acknowledged advantages of combined immunochemotherapy for tumor treatment, the high efficiency of co-delivery of these combined agents into the targeted tumor tissue is still challenging.
Zihan Xu   +8 more
semanticscholar   +1 more source

Heparin Binding Protein (CAP37) is an Opsonin for Staphylococcus aureus and Increases Phagocytosis in Monocytes

Inflammation, 1998
Heparin binding protein (HBP), also known as cationic antibiotic protein (CAP37) or azurocidin, is stored in azurophilic granules of neutrophils and is released to the extracellular space when granulocytes phagocytose Staphylococcus aureus. We investigated whether extracellular HBP also has the potential to increase phagocytosis of S.
M, Heinzelmann   +3 more
openaire   +2 more sources

Role of de Novo Protein Synthesis by Human Mononuclear Leukocytes in Opsonin-Independent Phagocytosis

Cellular Immunology, 1994
Human peripheral blood lymphocytes or the soluble (105,000g) supernatant of the lymphocyte lysate can increase the percentage of human monocytes ingesting particulate activators of the human alternative complement pathway, e.g., rabbit erythrocytes (Chakravarti et al., J. Immunol. 137, 880, 1986).
B, Chakravarti   +2 more
openaire   +2 more sources

Surfactant protein A is opsonin in phagocytosis of herpes simplex virus type 1 by rat alveolar macrophages

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1991
In the present study we used flow cytometry to investigate the phagocytosis of fluorescein isothiocyanate-labeled herpes simplex virus type 1 (FITC-HSV-1) by rat alveolar macrophages and the effects of surfactant protein A (SP-A) on this process.
J F, van Iwaarden   +5 more
openaire   +2 more sources

Peptidoglycan recognition protein MsPGRP in largemouth bass (Micropterus salmoides) mediates immune functions with broad nonself recognition ability.

Fish and Shellfish Immunology, 2023
Peptidoglycan (PGN) recognition proteins (PGRPs) are important immune factors in innate immunity that function in recognising pathogens and activating the immune system. These ubiquitous proteins are conserved in invertebrates and vertebrates.
Meng-Meng Huang   +7 more
semanticscholar   +1 more source

Complement-like protein from the phylogenetically primitive vertebrate,Eptatretus Stouti, is a Humoral Opsonin

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1992
Abstract 1. 1. Serum from the Pacific hagfish,Eptatretus stouti,contains a complement-like protein (CLP). 2. 2. CLP from unfractionated hagfish serum and from affinity-purified preparations binds to yeast cell surfaces. 3. 3. Incubation with CLP enhances the phagocytosis of yeast by hagfish leukocytes. 4. 4.
David A. Raftos   +2 more
openaire   +1 more source

Protein corona composition on nanoscale metal-organic frameworks and its impacts on nanoparticle-macrophage interactions.

Colloids and Surfaces B: Biointerfaces
As nanoscale metal-organic frameworks (MOFs) become increasingly prevalent, elucidating their fundamental interactions with proteins and cells is vital for evaluating their biological effects and biocompatibility.
Miao Huang   +7 more
semanticscholar   +1 more source

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