Recent Advances in Simulation Studies on the Protein Corona [PDF]
PharmaceuticsWhen flowing through the blood stream, drug carriers such as nanoparticles encounter hundreds of plasma proteins, forming a protein layer on the nanoparticle surface, known as the “protein corona”. Since the protein corona influences the size, shape, and
Hwankyu Lee
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Novel brain-targeted nanomicelles for anti-glioma therapy mediated by the ApoE-enriched protein corona in vivo [PDF]
Journal of Nanobiotechnology, 2021 Background The interactions between nanoparticles (NPs) and plasma proteins form a protein corona around NPs after entering the biological environment, which provides new biological properties to NPs and mediates their interactions with cells and ...
Zhe-Ao Zhang +11 more
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Role of structural specificity of ZnO particles in preserving functionality of proteins in their corona [PDF]
Scientific Reports, 2021 Reconfiguration of protein conformation in a micro and nano particle (MNP) protein corona due to interaction is an often-overlooked aspect in drug design and nano-medicine.
Urvashi Singh +6 more
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Protein corona formed on lipid nanoparticles compromises delivery efficiency of mRNA cargo [PDF]
Nature CommunicationsLipid nanoparticles (LNPs) are the most clinically advanced nonviral RNA-delivery vehicles, though challenges remain in fully understanding how LNPs interact with biological systems.
Elizabeth Voke +10 more
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EVennCorona: Annotating Protein Corona of Extracellular Vesicles by Venn Diagram [PDF]
Journal of Extracellular BiologyExtracellular vesicles (EVs) circulating in human blood are coated by adsorbed plasma proteins, termed the EV protein corona. The corona is an intrinsic property of EVs in vivo, forming through selective adsorption of tissue microenvironment secretome ...
Somchai Chutipongtanate
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Uptake of extracellular vesicles into immune cells is enhanced by the protein corona
Journal of Extracellular Vesicles, 2023 The influence of a protein corona on the uptake of nanoparticles in cells has been demonstrated in various publications over the last years. Extracellular vesicles (EVs), can be seen as natural nanoparticles.
Laura Dietz +7 more
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Physiological pH Transition‐Driven Protein Corona Dynamics Regulate Cellular Uptake and Inflammatory Responses of Silica Nanoparticles [PDF]
Advanced ScienceProtein corona alters the biological identities and interactions of nanoparticles with cells, needing to be thoroughly scrutinized before in vivo applications.
Yuting Ge +7 more
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Hard and Soft Protein Corona of Nanomaterials: Analysis and Relevance
Nanomaterials, 2021 Upon contact with a biological milieu, nanomaterials tend to interact with biomolecules present in the media, especially proteins, leading to the formation of the so-called “protein corona”. As a result of these nanomaterial–protein interactions, the bio-
Rafaela García-Álvarez +1 more
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The effect of protein corona formation on the nano-bio interaction of the Au/Nd2O3 nanocomposites [PDF]
Discover NanoAu/Nd2O3 nanocomposites (NCs) have potential applications in nanomedicine due to their unique physicochemical properties. The interaction of biomacromolecules with NCs, known as protein corona (PC) formation, is influenced by the surface characteristics,
Reyhaneh Bakhshi +4 more
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Surfactant-driven modulation of protein corona on solid lipid nanoparticles: Insights including molecular docking studies [PDF]
BMC Pharmacology and ToxicologyBackground Nanoparticles have been used in nanomedicine for therapeutic purposes. Lipids have been a popular choice of material in the synthesis of biocompatible nanoparticles due to their ability to encapsulate diverse therapeutic agents.
Shelly Roselyn Van Eyssen, Doğa Kavaz
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