Results 1 to 10 of about 3,834,350 (184)

Uptake of extracellular vesicles into immune cells is enhanced by the protein corona

Journal of Extracellular Vesicles, 2023
The influence of a protein corona on the uptake of nanoparticles in cells has been demonstrated in various publications over the last years. Extracellular vesicles (EVs), can be seen as natural nanoparticles.
Laura Dietz, Jennifer Oberländer, Ana Mateos‐Maroto, Jenny Schunke, Michael Fichter, Eva‐Maria Krämer‐Albers, Katharina Landfester, Volker Mailänder   +7 more
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EVennCorona: Annotating Protein Corona of Extracellular Vesicles by Venn Diagram [PDF]

Journal of Extracellular Biology
Extracellular vesicles (EVs) circulating in human blood are coated by adsorbed plasma proteins, termed the EV protein corona. The corona is an intrinsic property of EVs in vivo, forming through selective adsorption of tissue microenvironment secretome ...
Somchai Chutipongtanate
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Integrated top-down and bottom-up proteomics enables precise characterization of proteoforms within the protein corona [PDF]

Nature Communications
Precise characterization of proteoforms within the protein corona is essential for developing safer and more effective nanomedicines for diagnostic and therapeutic applications.
Seyed Amirhossein Sadeghi, Kun Li, Yifan Yue, Reyhane Tabatabaeian Nimavard, Shaun Grumelot, Amir Ata Saei, Hojatollah Vali, Fei Fang, Xiaowen Liu, Morteza Mahmoudi, Liangliang Sun   +10 more
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Protein corona formed on lipid nanoparticles compromises delivery efficiency of mRNA cargo [PDF]

Nature Communications
Lipid nanoparticles (LNPs) are the most clinically advanced nonviral RNA-delivery vehicles, though challenges remain in fully understanding how LNPs interact with biological systems.
Elizabeth Voke, Mariah L. Arral, Henry J. Squire, Teng-Jui Lin, Lining Zheng, Roxana Coreas, Alison Lui, Anthony T. Iavarone, Rebecca L. Pinals, Kathryn A. Whitehead, Markita P. Landry   +10 more
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The protein corona at the nano-bio interface: the need for standardized methodology and opportunities for neurodegenerative disease intervention [PDF]

RSC Advances
The “biological identity” of a nanoparticle is determined not only by its surface but by the complex protein corona (PC) it forms when entering a biological system.
Getasew Shitaye, Martina Dragone, Zewdie Mekonnen, Awet Ghebretinsae Tewelde, Maria Della Valle, Gaetano Caputo, Mohammadhossein Mosalaeizadehyazd, Gianluca D'Abrosca, Luigi Russo, Roberto Fattorusso, Carla Isernia, Gaetano Malgieri   +11 more
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Surface hydrophobicity and rigidity determines protein corona on orally delivered nanoparticles treating colitis [PDF]

Nature Communications
Disease-specific protein corona adsorbed on nanocarriers determines in vivo delivery efficiency. Macrophages can orchestrate inflammation resolution and mucosa repair, making them a promising therapeutic target in colitis.
Jiawei Wu, Mingjie Ni, Liyun Xing, Yating Wang, Xi Liu, Yaxian Zheng, Lian Li, Yuan Huang   +7 more
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The effect of protein corona formation on the nano-bio interaction of the Au/Nd2O3 nanocomposites [PDF]

Discover Nano
Au/Nd2O3 nanocomposites (NCs) have potential applications in nanomedicine due to their unique physicochemical properties. The interaction of biomacromolecules with NCs, known as protein corona (PC) formation, is influenced by the surface characteristics,
Reyhaneh Bakhshi, Saeed Jafarirad, Mahdieh Nemati, Farhad Bani, Amir Zarebkohan   +4 more
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Harnessing Protein Corona for Biomimetic Nanomedicine Design

Biomimetics, 2022
Nanoparticles (NPs) are usually treated as multifunctional agents combining several therapeutical applications, like imaging and targeting delivery.
Zhidong Chen, Xu Chen, Juyang Huang, Junqing Wang, Zhe Wang   +4 more
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Unfolded Protein Corona Surrounding Nanotubes Influence the Innate and Adaptive Immune System

Advanced Science, 2021
The plasma proteins around nanoparticles (NPs) form an outer protein corona, significantly influencing the subsequent immune response. However, it was uncertain whether the protein corona around NPs influences immune response.
Jun‐Young Park, Sung Jean Park, Jun Young Park, Sang‐Hyun Kim, Song Kwon, YunJae Jung, Dongwoo Khang   +6 more
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In situ analysis of nanoparticle soft corona and dynamic evolution

Nature Communications, 2022
How soft corona, the protein corona’s outer layer, contributes to biological identity of nanomaterials is largely because capturing protein composition of the soft corona in situ remains challenging.
Didar Baimanov, Jing Wang, Jun Zhang, Ke Liu, Yalin Cong, Xiaomeng Shi, Xiaohui Zhang, Yufeng Li, Xiumin Li, Rongrong Qiao, Yuliang Zhao, Yunlong Zhou, Liming Wang, Chunying Chen   +13 more
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