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Protein corona: Opportunities and challenges [PDF]
The International Journal of Biochemistry & Cell Biology, 2016 In contact with biological fluids diverse type of biomolecules (e.g., proteins) adsorb onto nanoparticles forming protein corona. Surface properties of the coated nanoparticles, in terms of type and amount of associated proteins, dictate their interactions with biological systems and thus biological fate, therapeutic efficiency and toxicity.
Saeid, Zanganeh +4 more
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In situ analysis of nanoparticle soft corona and dynamic evolution
Nature Communications, 2022 How soft corona, the protein corona’s outer layer, contributes to biological identity of nanomaterials is largely because capturing protein composition of the soft corona in situ remains challenging.
Didar Baimanov +13 more
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The nanoparticle protein corona formed in human blood or human blood fractions. [PDF]
PLoS ONE, 2017 The protein corona formed around nanoparticles in protein-rich fluids plays an important role for nanoparticle biocompatibility, as found in several studies during the last decade.
Martin Lundqvist +6 more
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Nanomaterials, 2023 When nanoparticles are introduced into the bloodstream, plasma proteins accumulate at their surface, forming a protein corona. This corona affects the properties of intravenously administered nanomedicines.
Susannah Emily Cornwell +2 more
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Applied Surface Science Advances, 2022 The nanoparticle surfaces interact readily with biomolecules, including proteins forming a corona. The protein layer that directly interacts with the nanoparticle surface is usually explored. Non-covalent interactions of proteins in the second layer have
Varsha P. Brahmkhatri +5 more
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Nanoparticles in the lung and their protein corona: the few proteins that count [PDF]
Nanotoxicology, 2016 The formation of protein coronae on nanoparticles (NPs) has been investigated almost exclusively in serum, despite the prevailing route of exposure being inhalation of airborne particles. In addition, an increasing number of nanomedicines, that exploit the airways as the site of delivery, are undergoing medical trials.
Harry J. Whitwell +7 more
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Isomeric Differences in Nanoparticle's Surface Chemistry Alter Macrophage Interactions In Vitro Due to Protein Corona. [PDF]
ACS OmegaConjeevaram SB, Kadaba A, Adjei IM.
europepmc +2 more sources
A Decade of the Protein Corona
ACS Nano, 2017 In this Perspective, we reflect on a decade of research on the protein corona and contemplate its broad implications for future science and engineering at the bio-nano interface. Specifically, we focus on the physical origins and time evolution of the protein corona, differences in the nanoparticle-protein entity in in vitro and in vivo environments ...
Pu Chun Ke +4 more
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Proteomics Analysis Reveals Distinct Corona Composition on Magnetic Nanoparticles with Different Surface Coatings: Implications for Interactions with Primary Human Macrophages. [PDF]
PLoS ONE, 2015 Superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as promising contrast agents for magnetic resonance imaging. The influence of different surface coatings on the biocompatibility of SPIONs has been addressed, but the potential impact of ...
Carmen Vogt +8 more
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Profiling Glycoproteins Enriched by Multinanoparticle Protein Corona. [PDF]
Anal ChemBiofluids, such as plasma and cerebrospinal fluid (CSF), present significant challenges for proteome and glycoproteome analysis due to their complex protein composition and wide dynamic range of protein abundances. Nanoparticle (NP)-based enrichment methods that rely on the formation of protein coronas to compress dynamic range have emerged as ...
Sutherland E +4 more
europepmc +3 more sources