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Recent Advances in Simulation Studies on the Protein Corona
PharmaceuticsWhen flowing through the blood stream, drug carriers such as nanoparticles encounter hundreds of plasma proteins, forming a protein layer on the nanoparticle surface, known as the “protein corona”. Since the protein corona influences the size, shape, and
Hwankyu Lee
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A Decade of the Protein Corona
ACS Nano, 2017 In this Perspective, we reflect on a decade of research on the protein corona and contemplate its broad implications for future science and engineering at the bio-nano interface. Specifically, we focus on the physical origins and time evolution of the protein corona, differences in the nanoparticle-protein entity in in vitro and in vivo environments ...
Pu Chun Ke +4 more
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Protein corona – from molecular adsorption to physiological complexity
Beilstein Journal of Nanotechnology, 2015 In biological environments, nanoparticles are enshrouded by a layer of biomolecules, predominantly proteins, mediating its subsequent interactions with cells.
Lennart Treuel +3 more
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Protein Corona Prevents TiO2 Phototoxicity.
PLoS ONE, 2015 Background & aimTiO2 nanoparticles have generally low toxicity in the in vitro systems although some toxicity is expected to originate in the TiO2-associated photo-generated radical production, which can however be modulated by the radical trapping ...
Maja Garvas +5 more
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Unravelling protein corona formation on pristine and leached microplastics [PDF]
Microplastics and NanoplasticsUpon entering the environment, the surface properties of pristine plastics are rapidly altered due to interactions with exogenous biomolecules, contaminants, and even microbiota, which ultimately alter their ecological impacts. When present in biological
Amanda Louise Dawson +3 more
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NanomaterialsUnderstanding both the physicochemical and biological interactions of nanoparticles is mandatory for the biomedical application of nanomaterials. By binding proteins, nanoparticles acquire new surface identities in biological fluids, the protein corona ...
Burcu Önal Acet +4 more
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Unraveling the In Vivo Protein Corona [PDF]
Cells, 2021 Understanding the behavior of nanoparticles upon contact with a physiological environment is of urgent need in order to improve their properties for a successful therapeutic application. Most commonly, the interaction of nanoparticles with plasma proteins are studied under in vitro conditions.
Johanna Simon +5 more
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Environmental dimensions of the protein corona [PDF]
Nature Nanotechnology, 2021 The adsorption of biomolecules to the surface of engineered nanomaterials, known as corona formation, defines their biological identity by altering their surface properties and transforming the physical, chemical and biological characteristics of the particles. In the first decade since the term protein corona was coined, studies have focused primarily
Korin E. Wheeler +6 more
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Protein corona formation around biocatalytic nanomotors unveiled by STORM [PDF]
, 2021 The interaction of nanoparticles with biological media is a topic of general interest for drug delivery systems and among those for active nanoparticles, also called nanomotors.
Samuel, Sánchez +4 more
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Polymeric Nanoparticles with Neglectable Protein Corona [PDF]
Small, 2020 Abstract The current understanding of nanoparticle–protein interactions indicates that they rapidly adsorb proteins upon introduction into a living organism. The formed protein corona determines thereafter identity and fate of nanoparticles in the body.
Irina Alberg +16 more
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