Human Opsonins Induced during Meningococcal Disease Recognize Transferrin Binding Protein Complexes [PDF]
Infection and Immunity, 1999 ABSTRACT Patient serum opsonins against transferrin binding protein A+B (TbpA+B) complexes from two Neisseria meningitidis strains (K454 and B16B6, with 85- and 68-kDa TbpB, respectively) were quantified by a functional phagocytosis and oxidative burst assay.
A K, Lehmann +5 more
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The adaptor molecule Nck localizes the WAVE complex to promote actin polymerization during CEACAM3-mediated phagocytosis of bacteria. [PDF]
PLoS ONE, 2012 BACKGROUND: CEACAM3 is a granulocyte receptor mediating the opsonin-independent recognition and phagocytosis of human-restricted CEACAM-binding bacteria.
Stefan Pils +5 more
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Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi. [PDF]
PLoS ONE, 2017 Complement is an important part of innate immunity. The alternative pathway of complement is activated when the main opsonin, C3b coats non-protected surfaces leading to opsonisation, phagocytosis and cell lysis.
Robert Kolodziejczyk +6 more
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Function of the lipopolysaccharide‐binding protein of Periplaneta americana as an opsonin
FEBS Letters, 1992 Previously, we reported the purification of an LPS‐binding protein from the hemolymph of the American cockroach that was specific for E. coli LPS. In this study we found that this protein participated in the clearance of E. coil cells injected into the abdominal cavity of the cockroach, and that hemocytes ingested E.
Jomori, Takahito, Natori, Shunji
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Biological significance of C-reactive protein, the ancient acute phase functionary
Frontiers in Immunology, 2023 C-reactive protein (CRP) is one of the major members of the family of acute phase proteins (APP). Interest in this CRP was the result of a seminal discovery of its pattern of response to pneumococcal infection in humans.
Shelley Bhattacharya, Chayan Munshi
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PLoS ONE, 2012 Control of macrophage capacity for apoptotic cell clearance by soluble mediators such as cytokines, prostaglandins and lipoxins, serum proteins, and glucocorticoids may critically determine the rate at which inflammation resolves.
Simon P Hart +3 more
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Frontiers in Immunology, 2023 IntroductionSystemic amyloidosis is a progressive disorder characterized by the extracellular deposition of amyloid fibrils and accessory proteins in visceral organs and tissues.
James S. Foster +11 more
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C-type lectin in Chlamys farreri (CfLec-1) mediating immune recognition and opsonization. [PDF]
PLoS ONE, 2011 BACKGROUND: C-type lectins are a superfamily of Ca(2+) dependent carbohydrate-recognition proteins that play significant diverse roles in nonself-recognition and clearance of invaders.
Jialong Yang +5 more
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Calreticulin and Galectin-3 Opsonise Bacteria for Phagocytosis by Microglia
Frontiers in Immunology, 2019 Opsonins are soluble, extracellular proteins, released by activated immune cells, and when bound to a target cell, can induce phagocytes to phagocytose the target cell. There are three known classes of opsonin: antibodies, complement factors and secreted
Tom O. J. Cockram +2 more
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A novel and rapid method to purify the human complement opsonin C3b from human plasma. [PDF]
Front ImmunolComplement opsonin C3b is at the center of the complement cascade. All complement initiation pathways converge when convertases activate C3, converting it into the anaphylatoxin C3a and the opsonin C3b, which can attach to surfaces via its freshly ...
Sichau J, Schmidt CQ.
europepmc +2 more sources