Results 91 to 100 of about 82,984,775 (304)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Arguments in favor opt-in and opt-out procedures.

, 2013
Arguments in favor opt-in and opt-out procedures.
Annelien L. Bredenoord (312242), Noor A. A. Giesbertz (312241), Johannes J. M. van Delden (312243)   +2 more
core   +1 more source

opt

, 2022
doc
openaire   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

OPT: perubahan iklim

, 2020
ii, 31 hlm.; ilus.: 29 ...
Andi Iqbal
core  

NHS national data opt-outs: trends and potential consequences for health data research

BJGP Open
Background: The English NHS data opt-out allows people to prevent use of their health data for purposes other than direct care. In 2021, the number of opt-outs increased in response to government-led proposals to create a centralised pseudonymised ...
John Tazare, Alasdair D Henderson, Jessica Morley, Helen A Blake, Helen I McDonald, Elizabeth J Williamson, Helen Strongman   +6 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Asking for Panel Consent in Web Surveys: Choice, Opt-in, or Opt-out?

Survey Research Methods
Some surveys ask respondents for consent to be recontacted for follow-up surveys after the initial  part of the survey has been completed. Based on an experiment, we compare three options for asking for this panel consent: choice (yes/no), opt-in, and ...
Oliver Lipps, Lukas Lauener, Anke Tresch
doaj  

‘If I donate my organs it’s a gift, if you take them it’s theft’: a qualitative study of planned donor decisions under opt-out legislation

BMC Public Health, 2019
Background There is a worldwide shortage of donor organs for transplantation. To overcome this, several countries have introduced an opt-out donor consent system.
Jordan Miller, Sinéad Currie, Ronan E. O’Carroll   +2 more
doaj   +1 more source