Results 111 to 120 of about 82,984,775 (304)

Opt-out organ donation without presumptions

, 2011
This paper defends an 'opt-out' scheme for organ procurement, by distinguishing this system from 'presumed consent' (which the author regards as an erroneous justification of it).
Ben Saunders, Saunders, B., Saunders, Ben   +2 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Evidence for the acclimation of ecosystem photosynthesis to soil moisture

Nature Communications
Ecosystem gross primary productivity (GPP) is the largest carbon flux between the atmosphere and biosphere and is strongly influenced by soil moisture.
Jinlong Peng, Jiwang Tang, Shudi Xie, Yiheng Wang, Jiaqiang Liao, Chen Chen, Chuanlian Sun, Jinhua Mao, Qingping Zhou, Shuli Niu   +9 more
doaj   +1 more source

Opt-in vs. Opt-out = opt-in-opt-out?: On the activation of the ICC's jurisdiction over the crime of aggression

, 2018
Völkerrechtsblog
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Optimized nitrogen management improves grain yield of rice by regulating panicle architecture in South China

Heliyon
Optimized nitrogen (N) management (OPT), with reduced total N input and more N applied during panicle development, has been proved to increase grain yield of rice through panicle enlargement.
Xiangyu Hu, Yanzhuo Liu, Xuhua Zhong, Rui Hu, Meijuan Li, Bilin Peng, Junfeng Pan, Kaiming Liang, Youqiang Fu, Nongrong Huang   +9 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Effects of drought on optimum temperature of carbon fluxes in temperate grasslands

Environmental Research Letters
Ecosystem carbon flux components, including ecosystem gross primary productivity (GPP), ecosystem respiration (ER), and net ecosystem productivity (NEP), are the most direct indicators of ecosystem production capacity, carbon sequestration, and climate ...
Tiancheng Su, Yanbing Wang, Cuihai You, Xingguo Han, Shiping Chen   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The economics of financial privacy : to opt out or to opt in? [PDF]

Gramm-Leach-Bliley Act ; Financial services industry - Law and ...
Jeffery M. Lacker
core