Results 21 to 30 of about 62,534 (254)
Indian Journal of Ophthalmology, 2014 Background: Optic nerve atrophy is an important ophthalmological sign that may be associated with serious systemic conditions having a significant bearing on the overall morbidity of the child.
Supriya Chinta +5 more
doaj +1 more source
A novel homozygous variant in the SPG7 gene presenting with childhood optic nerve atrophy
American Journal of Ophthalmology Case Reports, 2022 Purpose: To describe a case of hereditary spastic ataxia (HSP) presenting with childhood optic nerve atrophy and report a novel homozygous variant in the SPG7 gene.
Kathrine O. Eriksen +6 more
doaj +1 more source
Wolfram syndrome with childhood glaucoma: A rare case report with review of literature
Journal of Clinical Ophthalmology and Research, 2020 Wolfram syndrome (WFS) is a rare neurodegenerative disorder characterized by young-onset diabetes mellitus, central diabetes insipidus, optic nerve atrophy, and hearing loss.
Divya Kesarwani +5 more
doaj +1 more source
Frontiers in Neurology, 2022 IntroductionDentatorubral-pallidoluysian atrophy (DRPLA) is an autosomal dominant neurodegenerative disease with various neurological manifestations. Corneal endothelial degeneration and optic atrophy have been reported separately; however, there are no ...
Shunya Takizawa +7 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Türk Oftalmoloji Dergisi, 2011 Pur po se: To evaluate the relationship between peripapillary atrophy and optic disc parameters measured by Heidelberg Retina Tomography (HRT) and visual field findings in eyes with primary open-angle glaucoma.
Tamer Takmaz +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Orphan disease: Cherubism, optic atrophy, and short stature
Indian Journal of Radiology and Imaging, 2018 A 12-year-old female presented with complaints of progressive visual impairment in both her eyes. On clinical examination, she was short for her age and her ophthalmoscopic examination revealed bilateral optic atrophy.
Balaji Jeevanandham +4 more
doaj +1 more source
Interdisciplinary Neurosurgery, 2020 Background: To date, the etiology of optic nerve sheath calcifications is unclear and visual loss secondary to optic nerve sheath calcifications has been reported infrequently.
Patrick K. Jowdy +2 more
doaj +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source