Results 141 to 150 of about 62,463 (295)

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source

Development of a novel model of optic neuritis to assess neuroprotective and repair strategies in multiple sclerosis

, 2012
PhDMultiple sclerosis (MS) is a putative autoimmune disease of the central nervous system (CNS), which often affects the optic nerve pathway. Optic neuritis (ON) is a clinical feature of MS that can cause loss of vision due to conduction block and ...
Lidster, Katie
core  

Multiple Sclerosis–Like Disorder in Opa1-Related Autosomal Dominant Optic Atrophy

, 2008
Autosomal dominant optic atrophy (ADOA) is a progressive ophthalmologic disorder caused in two-thirds of the cases by a mutation in the optic atrophhy 1 (IPA1) gene, a nuclear gene encoding a mitochondrial protein.
D. Loiseau, Dubas, Frédéric, Amati-Bonneau, Patrizia, Verny, Christophe, P. Lejeune, F. Dubas, D. Bonneau, C. Verny, Loiseau, Dominique, A. Chevrollier, Bonneau, Dominique, C. Scherer, P. Reynier, Lejeune, P., P. Amati-Bonneau, Reynier, Pascal, V. Guillet, Gueguen, Naïg, N. Gueguen, Scherer, Clarisse, Guillet, Virginie, Chevrollier, Arnaud   +21 more
core   +2 more sources

A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley   +1 more source

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

Arthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi, for the Multicenter Osteoarthritis Study Group   +7 more
wiley   +1 more source

Early pericalcarine atrophy in acute optic neuritis is associated with conversion to multiple sclerosis [PDF]

, 2011
Background: Previous work showed that pericalcarine cortical volume loss is evident early after presentation with acute clinically isolated optic neuritis (ON).
Wheeler-Kingshott, CAM, Jenkins, TM, Toosy, AT, Ciccarelli, O, Atzori, M, Thompson, AJ, Miller, DH   +6 more
core  

A Compact Spin‐Coated Graphene UWB Antenna for Breast Tumor Detection

Advanced Engineering Materials, EarlyView.
A compact, spin‐coated graphene ultra‐wideband patch antenna designed for breast tumor detection, capable of distinguishing between malignant and benign tumors. This innovative antenna can serve as an effective initial screening tool, particularly in resource‐limited settings such as rural areas, where access to advanced medical equipment like MRI and ...
Raja Rashidul Hasan, Shuvra Saha, Sumit Hassan Eshan, Rinku Basak, Md. Nahian Al Subri Ivan, Ahmed Murtuza Saleque, Raja Tariqul Hasan Tusher, Sadia Zabin, Md. Abdur Rahman, Yuen Hong Tsang   +9 more
wiley   +1 more source

Targeting DRP1 with Mdivi-1 to correct mitochondrial abnormalities in ADOA+ syndrome

JCI Insight
Autosomal dominant optic atrophy plus (ADOA+) is characterized by primary optic nerve atrophy accompanied by a spectrum of degenerative neurological symptoms.
Yan Lin, Dongdong Wang, Busu Li, Jiayin Wang, Ling Xu, Xiaohan Sun, Kunqian Ji, Chuanzhu Yan, Fuchen Liu, Yuying Zhao   +9 more
doaj   +1 more source

Mitochondrial fusion mediator optic atrophy 1 as regulator of cell metabolism in macrophages

, 2022
Residing at the inner mitochondrial membrane, optic atrophy 1 (Opa1) constitutes a prominent regulator of mitochondrial morphology. It executes fusion of inner mitochondrial membranes, yet it also influences electron transport chain activity and mitochondrial genome maintenance.
openaire   +2 more sources

Recycling of NiTi Shape Memory Alloys: Fundamental and Technological Aspects of a Vacuum Induction Melting Processing Route

Advanced Engineering Materials, EarlyView.
The present study investigates recycling of NiTi shape memory alloys via vacuum induction melting. An ingot was synthesized from elemental Ni and Ti and subjected to three subsequent remelting cycles. Remelting increases process durations and impurity levels and adversely affects microstructures and functional properties.
Sakia Sophia Noorzayee, Son Tung Mai, Sarath Menon, Braulio Gadiel Sánchez Ortega, Ralf Drautz, Alexander Kauffmann, Gunther Eggeler, Jan Frenzel   +7 more
wiley   +1 more source